1GXE,2ILL,1WIT


Conserved Protein Domain Family
Ig_Titin_like

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cd05748: Ig_Titin_like (this model, PSSM-Id:143225 is obsolete and has been replaced by 409406)
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Immunoglobulin (Ig)-like domain of titin and similar proteins
Ig_Titin_like: immunoglobulin (Ig)-like domain found in titin-like proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is gigantic, depending on isoform composition it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone. It appears to function similarly to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. Within the sarcomere, titin is also attached to or is associated with myosin binding protein C (MyBP-C). MyBP-C appears to contribute to the generation of passive tension by titin, and similar to titin has repeated Ig-like and FN-III domains. Also included in this group are worm twitchin and insect projectin, thick filament proteins of invertebrate muscle, which also have repeated Ig-like and FN-III domains.
Statistics
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PSSM-Id: 143225
Aligned: 49 rows
Threshold Bit Score: 83.014
Created: 27-Sep-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GXE_A          35 KLRLDVPISGDPAPTVIWQkaitqgnkaparpapdapedtgdsdewvfdkkllcetegrvRVETTKDRSIFTVegaekeD 114   human
AAC27550      3909 PVNLNIPISGAPTPTIEWKrgdlkl-----------------------------eegkriSYETNSERTLFRIddsnrrD 3959  fruit fly
BAC00784      2080 PLDIPVGVSGTPTPTVSWEkngrp-------------------------------vdnraKCTSSEEDAKLHVdkaergD 2128  Mediterrane...
ABD64784      4359 DFSIHVPYVGFPKPTASWYsndtvl-----------------------------dddqrvHQHLTDEAASFVVknskrsD 4409  Drosophila ...
Q8WZ42       27816 SVKLRAGISGKPAPTIEWYkddkel-----------------------------qtnalvCVENTTDLASILIkdadrlN 27866 human
XP_001203170   953 KFEINLPLTGFPTPTATWElgsspv-----------------------------kesgrvLVTTARTYTKLKVdsaerqD 1003  purple urchin
Q05623         255 AVNLLIPFQGKPQPQVTWTkdnqpl------------------------------dtsrvNIRNTDKDTIFFIrtaqrsD 304   chicken
CAF92338      6528 TIVLPAKMTGIPIPTAKWMtdgkdi-----------------------------tsegrcHIETAGSSTILSIsecqrgD 6578  Tetraodon n...
Q8WZ42       30682 PVELVIPIAGRPPPAASWFfagskl-----------------------------reservTVETHTKVAKLTIrettirD 30732 human
CAA33463       998 TVRWEVKIGGEPIPEVKWFkgnqqle----------------------------ngiqltIDTRKNEHTILCIpsamrsD 1049  nematode
1GXE_A         115 EGVYTVTVKNpvGEDQVNLTVKV 137   human
AAC27550      3960 SGKYTVTAANefGKDTADIEVIV 3982  fruit fly
BAC00784      2129 TGKYTITVTNesGSMSADVNVIV 2151  Mediterranean mussel
ABD64784      4410 SGQYRLQLKNpsGFDTATINVKV 4432  Drosophila virilis
Q8WZ42       27867 SGCYELKLRNamGSASATIRVQI 27889 human
XP_001203170  1004 AGRYTITVKNdsGSDTARVKVTV 1026  purple urchin
Q05623         305 SGKYQLSVRIngAEDKAILDIRV 327   chicken
CAF92338      6579 TGEYVLIVTNpaGSKTVALHVTV 6601  Tetraodon nigroviridis
Q8WZ42       30733 TGEYTLELKNvtGTTSETIKVII 30755 human
CAA33463      1050 VGEYRLTVKNshGADEEKANLTV 1072  nematode
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