3M1I,3GB8,2X1G,2XWU,1Z3H,3A6P,1M5N


Conserved Protein Domain Family
IBN_N
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smart00913: IBN_N 
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Importin-beta N-terminal domain
Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.
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Statistics
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PSSM-Id: 197981
Aligned: 236 rows
Threshold Bit Score: 32.9857
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3M1I_C         36 AQEILTKFQDNPDAWQKADQILQFst---nPQSKFI-ALSILDKLITRKWKLLPNDHRIGIRNFVVGMIIS 102  baker's yeast
XP_001381971  380 AEKALVEFTNSPDCLSKCQLLLERgs---sSYSQLL-AATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLAT 446  gray short-tailed opossum
XP_001653893   34 AEKALYLFQEDPDALPKCQQLLDRsn---sAYSQLL-AATTLTKLVSKNIQALSLQQRVDIRNYILNYLAT 100  yellow fever mosquito
NP_001100464   30 AEKALLELIDSPECLSKCQLLLEQgt---tSYAQLL-AATCLSKLVTRI-NPLPVEQRIDIRNYILNYVAS 95   Norway rat
NP_505698      26 AESNLAELSESpeCLQRCMLLFARg----dYPYGPMvASTTLMKLLGGKTS-ITSVQKLELAKYLLEMLGQ 91   nematode
XP_001657960   15 SENIFMNFRKTksPYVLCQTILEksvvdlvLFEAAD----VLKKAIIaEWKyIPDQDKASLRQyLLNYIIQ 81   yellow fever mosquito
XP_002121599   31 AEEFLLSFRRSkvSFNVCWEILDkssspsvQYHAAA----TMKESVIrDWEtMDDSTRLSVQQfILNFLTQ 97   Ciona intestinalis
NP_196230      34 AENSLRCFSVNTDYISQCQYILDNs----sKPYSLMlASSSLLKQVT--DHtLPLNLRLDIRAYIVNYLAT 98   thale cress
XP_002125362   56 ktpfldslaeiqgtrvyyatmhsaqydilvNPYSLLiAASTLTKRVTKSGSpLPMQQRLDIRNYVLNFLYT 126  Ciona intestinalis
NP_001188596   25 AEKALVTFVSSQDALPKCQLLLQRa----dSSYAQLlAASTLTKL----IQgLSLQERIDIRSYALNYLAT 87   fruit fly
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