1MK2


Conserved Protein Domain Family
MH2_SMAD_2_3
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cd10985: MH2_SMAD_2_3 
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C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
The MH2 domain is located at the C-terminus of the SMAD (small mothers against decapentaplegic) family of proteins, which are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The MH2 domain is responsible for type I receptor interaction, phosphorylation-triggered homo- and hetero-oligomerization, and transactivation. It is negatively regulated by the N-terminal MH1 domain. SMAD2 and SMAD3 are receptor regulated SMADs (R-SMADs). SMAD2 regulates multiple cellular processes, such as cell proliferation, apoptosis and differentiation, while SMAD3 modulates signals of activin and TGF-beta.
Links
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Statistics
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PSSM-Id: 199826
Aligned: 13 rows
Threshold Bit Score: 427.808
Created: 16-Aug-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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trimer
Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the MH2 domain homotrimer structures of Drosophila melanogaster Mad and human SMAD1
  • Comment:Upon phosphorylation of the last two Ser residues of the flexible C-terminal SSXS motif, R-SMADs form extremely stable homotrimers as well as heteromeric SMAD complexes with SMAD4.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #    ## #          #####   #   #  # ##     ## ###  #           
1MK2_A         5 VTYCEPaFWCSISYYELNqRVGETFHASQPSMTVDGFTDPSnSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIggEV 84  human
Q9I9P9       267 VTYSEPaFWCSIAYYELNqRVGETFHASQPSLTVDGFTDPSnSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIggEV 346 zebrafish
P84023       225 VTYCEPaFWCSISYYELNqRVGETFHASQPSMTVDGFTDPSnSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIggEV 304 chicken
NP_001084964 266 VTYSEPaFWCSIAYYELNqRVGETFHASQPSLTVDGFTDPSnSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIggEV 345 African clawed ...
EFX84472     199 VMYCEPaFWCSISYYELNtRVGETFHASQPSITVDGFTDPSnSERFCLGLLSNVNRNPVVEQTRRHIGKGVRLYYIggEV 278 common water flea
NP_001071816 245 VAYCEPpFWCSISYYEMNlRVGETFHASQPSLTVDGFTDPSnSERFCLGLLSNINRNQQIELTRRHVGKGVRLYYIggEV 324 Ciona intestinalis
BAF45857     226 VSYCEPpFWCSIAYYEMNqRVGETFHASQPSLTIDGFTDPSsSERFCLGLLSNVNRDPQVEQTRRHIGKGVRLYYIggEV 305 purple urchin
EEN64062     224 VTYTEPtFWCSIAYYEMNtRVGETFHASQPSLTVDGFTDPSnSERFCLGLLSNVNRNHVIEQTRRHIGKGVRLYYIggEV 303 Florida lancelet
ABX57736     212 VTYKEPaFWCSIAYYELNnRVGEPFHASQPSLTVDGFTDPSnSERFCLGLLSNINRTQQVEMTRRHIGKGVRLYYIggEV 291 Pinctada fucata
EFV60166     255 VEYCEPpFWCSVSYYEMNkRLGETFHASQPSLTVDGFCDPSnAERFCLGLLSNVNRTPNVVEARKHVGRGARFYYIggEV 334 Trichinella spi...
AAO45214     107 VMYHEPaFWCSISYYELNtRVGETFHASQPSITVDGFTDPSnSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIggEV 186 fruit fly
EDO39594     222 IQYTEPtYWCSISYYEMNtRVGETFHASQPSLTVDGFTDPSsSDRFCLGLLSNINRNPPIEMTRKHIGKGVRLYYIggEV 301 starlet sea ane...
CAZ35942     448 VAYQEPeYWCSLYYYEMNtRVGDTFHCSSPCLTVDGFTDPNrHNRFCLGLLSNVNRGHQIELTRRHIGKGVKLYYIggEV 527 Schistosoma man...

Feature 1                                                                 #  #  #   # #   ###    
1MK2_A        85 FAECLSDSAIFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAALLAQSVNQgFEAVYQLTRMCTIRMSFVKGWGAE 164 human
Q9I9P9       347 FAECLSDSAIFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAALLAQSVNQgFEAVYQLTRMCTIRMSFVKGWGAE 426 zebrafish
P84023       305 FAECLSDSAIFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAALLAQSVNQgFEAVYQLTRMCTIRMSFVKGWGAE 384 chicken
NP_001084964 346 FAECLSDSAIFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAALLAQSVNQgFEAVYQLTRMCTIRMSFVKGWGAE 425 African clawed ...
EFX84472     279 FAECLSDSSIFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAALLSQSVSQgFEAVYQLTRMCTIRMSFVKGWGAE 358 common water flea
NP_001071816 325 FAECLGESSIFVQSPNCNNRYgWHPATVVKIPPgCNLKIFNNQEFAALLSQLVNQgFEAVYQLTRMCTIRMSFVKGWGAE 404 Ciona intestinalis
BAF45857     306 FAECLSDSSIFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAAQLSQSVNRgFEAVYQLTRMCTIRMSFVKGWGAE 385 purple urchin
EEN64062     304 FAECLSESSVFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAQLLSQSVSQgFEAVYQLTRMCTIRMSFVKGWGAE 383 Florida lancelet
ABX57736     292 FAECLSESAVFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAALLAQSVNQgFESVYQLTRMCTIRMSFAKGWGAE 371 Pinctada fucata
EFV60166     335 FAECMSESAIFVQSPNCNQRYgWHPATVCKVPPgCNLKIFNNQEFAALLSMSVPQgFEAVYALTRMCTIRVSFVKGWGAE 414 Trichinella spi...
AAO45214     187 FAECLSDSSIFVQSPNCNQRYgWHPATVCKIPPgCNLKIFNNQEFAALLSQSVSQgFEAVYQLTRMCTIRMSFVKGWGAE 266 fruit fly
EDO39594     302 FAECLSDSSIFVQSPNCNQRYnWHPATVCKIPPgCNLKIFNNQEFAQLLSQSVNQgFEAVYALTRMCTIRMSFVKGWGAE 381 starlet sea ane...
CAZ35942     528 FAECLSDSAIFVQSPNCNYMYkWHPATVCKIPPgCNLKIFNNQEFANLLTENVTKgFEAVYSLTNMCTIRMSFVKGWGAD 607 Schistosoma man...

Feature 1        # #   #    # # # #  ## ##  ##  
1MK2_A       165 YRRQTVTSTPCWIELHLNgPLQWLDKVLTQM 195 human
Q9I9P9       427 YRRQTVTSTPCWIELHLNgPLQWLDKVLTQM 457 zebrafish
P84023       385 YRRQTVTSTPCWIELHLNgPLQWLDKVLTQM 415 chicken
NP_001084964 426 YRRQTVTSTPCWIELHLNgPLQWLDKVLTQM 456 African clawed frog
EFX84472     359 YRRQTVTSTPCWIELHLNgPLQWLDRVLTQM 389 common water flea
NP_001071816 405 YRRQTVTATPCWIELHLNgPLQWLDKVLTQM 435 Ciona intestinalis
BAF45857     386 YRRQTVTSTPCWIELHLNgPLQWLDRVLTQM 416 purple urchin
EEN64062     384 YRRQTVTSTPCWIELHLNgPLQWLDKVLTQM 414 Florida lancelet
ABX57736     372 YRRQTVTSTPCWIEIHLNgPLQWLDRVLTQM 402 Pinctada fucata
EFV60166     415 YRRQTITSTPCWIELHLNgPLQWLDRVLTQM 445 Trichinella spiralis
AAO45214     267 YRRQTVTSTPCWIELHLNgPLQWLDRVLTQM 297 fruit fly
EDO39594     382 YRRQTVTSTPCWIELHLNgPLQWLDKVLTQM 412 starlet sea anemone
CAZ35942     608 YRRQTVTSTPCWIEIHLNgPLQWLDRVLSQM 638 Schistosoma mansoni

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