1N0V,2EFG,2YWE,1WDT,2H5E,1G7T,1TUI,1KK3,1EFU,1WB3,1IJE,1ZUN


Conserved Protein Domain Family
GTP_translation_factor

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cd00881: GTP_translation_factor 
Click on image for an interactive view with Cn3D
GTP translation factor family primarily contains translation initiation, elongation and release factors
The GTP translation factor family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function.
Statistics
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PSSM-Id: 206647
Aligned: 31 rows
Threshold Bit Score: 117.396
Created: 10-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1TUI: Thermus aquaticus EF-Tu binds GDP and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D
  • Citation:PMID 8939739

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ######                                                                  
1N0V_D         21 NMSVIAHVDHGKSTLTDSLVQragiisaakagea------rftdtrkdeqergITIksTAISLYsemsdedvkeikqktd 94   baker's yeast
2EFG_A         14 NIGIAAHIDAGKTTTTERILYytgrihkigevheg----aatmdfmeqerergITItaAVTTCFwk-------------- 75   Thermus therm...
2YWE_A          8 NFCIIAHVDHGKSTLADRLLEytgaiserekreq-------lldtldverergITVkmQAVRMFykakd----------- 69   Aquifex aeolicus
2H5E_A         15 TFAIISHPDAGKTTITEKVLLfgqaiqtagtvkgrgsnqhaksdwmemekqrgISIttSVMQFPyh-------------- 80   Escherichia c...
1TUI_B         13 NVGTIGHVDHGKTTLTAALTYvaaaenpnvevkdy-----gdidkapeerargITIntAHVEYEta-------------- 73   Thermus aquat...
ABA27171       78 TISVAGSINSGKSSFLTSIISfnspylkdsiy----------khmrtdedimkTTIimTPLLKSirkn------------ 135  Bigelowiella ...
AAN36428       26 NIGILAHIDAGKTTISEDILYqskeikvkgnindq----ntqldflkqerergITIksAYSCFEwn-------------- 87   Plasmodium fa...
NP_001026672  131 NVTLCGHLHHGKTCFVDCLIEqthpeirkrydqdl-----cytdilfteqergVGIksTPVTIVlpdtk----------- 194  chicken
AAD40613        5 NVGIFAHIDAGKTTLLERILYetgkirrpgtieeg----ttesdylqeeiergISIqsTLARVFwpnek----------- 69   Leptospira in...
Q46306          6 NIGIVAHVDAGKTTITENLLYysgaiksvgrvdlg----ntqtdsmelerkrgITIksSTISFNwn-------------- 67   Clostridium p...
Feature 1                                                                         ## #            
1N0V_D         95 gnsfLINLIDSPGHVdFSSEVTAALrvTDGALVVVDTIEgvcvQTETVLRQalg-eriKPVVVINKVDrallelqvsked 173  baker's yeast
2EFG_A         76 --dhRINIIDTPGHVdFTIEVERSMrvLDGAIVVFDSSQgvepQSETVWRQaek-ykvPRIAFANKMDktg-------ad 145  Thermus therm...
2YWE_A         70 gntyKLHLIDTPGHVdFSYEVSRALaaCEGALLLIDASQgieaQTVANFWKave-qdlVIIPVINKIDlps-------ad 141  Aquifex aeolicus
2H5E_A         81 --dcLVNLLDTPGHEdFSEDTYRTLtaVDCCLMVIDAAKgvedRTRKLMEVtrl-rdtPILTFMNKLDrdi-------rd 150  Escherichia c...
1TUI_B         74 --krHYSHVDCPGHAdYIKNMITGAaqMDGAILVVSAADgpmpQTREHILLarqvgvpYIVVFMNKVDmvdd-----pel 146  Thermus aquat...
ABA27171      136 nkynTYYFLDTPGHSnLFQDFNLALciSDGVIITIDSIEgvtlQTKKIINScly-tkkKIFILITKIDrliselrlppst 214  Bigelowiella ...
AAN36428       88 --kiKVNLIDTPGHIdFSNETFISLcvLDKCIIVIDSKEgvqiQTINIFRYike--nlPIYFFLNKMDinh-------id 156  Plasmodium fa...
NP_001026672  195 gksfLFNIIDTPGHVnFSDEVTAGLriSDGVVLFIDAAEgvmlNTERLIKHavq-erlAVTVCINKIDrlilelklpptd 273  chicken
AAD40613       70 esrmLFQFLDNPGHLdFQSQTSASLivADLGIVLIDAFEglksQTLQNVEWlrk-rkiPILFFLNKLDrtg-------id 141  Leptospira in...
Q46306         68 --nvKVNIIDTPGHVdFISEVERSLnsLDGAILVISGVEgiqsQTRILFDTlke-lniPTIIFVNKLDrig-------an 137  Clostridium p...
Feature 1                                                                                         
1N0V_D        174 LYQTFARTVESVnvivstyadev--------------------------------------------------------- 196  baker's yeast
2EFG_A        146 LWLVIRTMQERLgarpvvmqlpigredtfsgiidvlrmkaytygndlgtdireipipeeyl------------------- 206  Thermus therm...
2YWE_A        142 VDRVKKQIEEVLgl------------------------------------------------------------------ 155  Aquifex aeolicus
2H5E_A        151 PMELLDEVENELkigcapitwpigcgklfkgvyhlykdetylyqsgkghtiqevriv----------------------- 207  Escherichia c...
1TUI_B        147 LDLVEMEVRDLLnqyef--------------------------------------------------------------- 163  Thermus aquat...
ABA27171      215 FYDKIQSIIFDVnliiknsnk----------------------------------------------------------- 235  Bigelowiella ...
AAN36428      157 IDSNFLSIKNRLtkkgllitypiyenkklkyildipsmvlysyphinygqtfmynsyflktllegslyekklyshfamin 236  Plasmodium fa...
NP_001026672  274 AYYKLRHIVDEVnglismystd---------------------------------------------------------- 295  chicken
AAD40613      142 ITDSLVDLEAVLgkepillwkegetcsllkegssdqellpllew------------------------------------ 185  Leptospira in...
Q46306        138 FNKVFEEIKKNMsnkvvrlqevydvgskavyikklfdtciinddainv-------------------------------- 185  Clostridium p...
Feature 1                                                                                         
1N0V_D        197 ------------------------------------------------------------------lgdvqvyparGTVA 210  baker's yeast
2EFG_A        207 ---------------------------dnareyheklvevaadfdenimlkylegeepteeelvaairkgtidlkiTPVF 259  Thermus therm...
2YWE_A        156 --------------------------------------------------------------------------dpEEAI 161  Aquifex aeolicus
2H5E_A        208 --------------------------------kglnnpdldaavgedlaqqlrdelelvkgasnefdkelflageiTPVF 255  Escherichia c...
1TUI_B        164 ------------------------------------------------------------------------pgdeVPVI 171  Thermus aquat...
ABA27171      236 -------------------------------------------------------------------kqdyfsfskSNIG 248  Bigelowiella ...
AAN36428      237 pkpdnlskenknknninianvlnddiidyiikkreeiieilcdldntieykylnnipisyehfknslslcidkkyiFPIF 316  Plasmodium fa...
NP_001026672  296 -------------------------------------------------------------------enlvlspllGNVC 308  chicken
AAD40613      186 --------------------------------------------deklserylkhpdslselaregfaegfwknqfFPVF 221  Leptospira in...
Q46306        186 ----------------------------------------lsdldeafleryiggiepdkeeiqeklslyaregslYPVF 225  Clostridium p...
Feature 1           ###                                                                           
1N0V_D        211 FGSGLhgwaftirqfatryakkfgvdkakmmdrlwgdsffnpktkkwtnkdtdaegkplerafn---------------- 274  baker's yeast
2EFG_A        260 LGSALknk------------------------------------------------------------------------ 267  Thermus therm...
2YWE_A        162 LASAKegi------------------------------------------------------------------------ 169  Aquifex aeolicus
2H5E_A        256 FGTALgnf------------------------------------------------------------------------ 263  Escherichia c...
1TUI_B        172 RGSALlaleemhknpkt--------------------------------------------------------------- 188  Thermus aquat...
ABA27171      249 ILSAEiglfltseilnklyhsiyptifklffpkewiwhtenfivgknilksnpkepgshnpiiffaiipiyklysfclse 328  Bigelowiella ...
AAN36428      317 SGSALhsy------------------------------------------------------------------------ 324  Plasmodium fa...
NP_001026672  309 FSSSQysicftlgsfakiyadtygdinyqefakrlwgdiyfnpktrkftkkaptsssqrsfve----------------- 371  chicken
AAD40613      222 GGAALhgdgvrellavlel------------------------------------------------------------- 240  Leptospira in...
Q46306        226 CGAAAigl------------------------------------------------------------------------ 233  Clostridium p...
Feature 1                                                                                         
1N0V_D        275 --------------------------------mfildpifrlftaimnfkkdeipvllekleivlkgdekdlegkallkv 322  baker's yeast
2EFG_A            --------------------------------------------------------------------------------      Thermus therm...
2YWE_A            --------------------------------------------------------------------------------      Aquifex aeolicus
2H5E_A            --------------------------------------------------------------------------------      Escherichia c...
1TUI_B        189 ------------------------------------------------------------------------------kr 190  Thermus aquat...
ABA27171      329 nplkimqfihktnfsntllnlnfplknlmkfvfksvfdypqstyekfseyfesskhlnqlftnsmskqsskkssifshta 408  Bigelowiella ...
AAN36428          --------------------------------------------------------------------------------      Plasmodium fa...
NP_001026672  372 ---------------------------------fileplykilaqvvgdvdttlprtldelgihltkeelklnirpllrl 418  chicken
AAD40613      241 -----------------------------------------------------------------------------lsk 243  Leptospira in...
Q46306            --------------------------------------------------------------------------------      Clostridium p...
Feature 1                                
1N0V_D        323 vmrkflpaadALLEMIVLHLPSP 345  baker's yeast
2EFG_A        268 -------gvqLLLDAVVDYLPSP 283  Thermus thermophilus
2YWE_A        170 -------gieEILEAIVNRIPPP 185  Aquifex aeolicus
2H5E_A        264 -------gvdHMLDGLVEWAPAP 279  Escherichia coli BW2952
1TUI_B        191 genewvdkiwELLDAIDEYIPTP 213  Thermus aquaticus
ABA27171      409 knhfydkymeKKVFLGIKFFPNS 431  Bigelowiella natans
AAN36428      325 -------gvhILLDYITHNEKGM 340  Plasmodium falciparum 3D7
NP_001026672  419 vckkffgeftGFVDMCVQHIPSP 441  chicken
AAD40613      244 tfrpelrpkeELGIVFKRELHPD 266  Leptospira interrogans
Q46306        234 -------gieDLLDGICSYFPFA 249  Clostridium perfringens

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