11387159 239 HKPGGNTQlipermkehlqatgGgVVTRFPPEPNGYLHIGHSKAIAVNFGFARYHNGVCYLRFDDTNP--EAEEE----R 312 fission yeast 6686013 62 LPPLPGAVe-------------GrVKLRFAPNPDFVIHMGNARPAIVNHEYARMYKGRMVLRFEDTDPrtKTPLR----E 124 Aeropyrum pernix 2500977 83 LELPN--Vk-------------DkVVMRFAPNPSGPLHIGHARAAVLNDYFVKKYGGKLILRLEDTDP--KRVLP----E 141 Methanocaldococcus ... 20094194 88 LKPLPGAEp-------------GnVRLRFAPNPSGPLHIGHARAAVLNDEYARRYDGTLVLRIEDTDP--RRVDP----E 148 Methanopyrus kandle... 3334350 87 LRELAGVK--------------GeVVLRFAPNPSGPLHIGHARAAILNHEYARKYDGRLILRIEDTDP--RRVDP----E 146 Methanothermobacter... 13878788 89 LPPLPKAEk-------------GkVVTRFAPNPDGAFHLGNARAAILSYEYAKMYGGKFILRFDDTDPkvKRPEP----I 151 Pyrococcus abyssi 18313726 91 LPELP-NVr-------------GgVVVRFAPNPDFVLHLGSARPAILNYAYRIKYGGKFILRFEDTDPriKSPLVteevN 156 Pyrobaculum aerophilum 6686004 88 LPLLPKAEk-------------GkVVTRFAPNPDGAFHLGNARAAILSYEYAKMYGGKFILRFDDTDPkvKRPEP----I 150 Pyrococcus horikoshii 2500979 92 LPPLP-NVk-------------GqVVTRFAPNPDGPLHLGNARSAILSYEYAKMYNGKFILRFDDTDPkvKRPIL----D 153 Sulfolobus solfatar... 13541917 86 LPDLQG-Vn-------------GhVVMRLAPSPSGPLHIGHTRMAILNDEYVKRYGGDLILRIEDTNP--TNIDP----E 145 Thermoplasma volcanium
11387159 313 YFESIKDLVAWLGFQPYKITYSSDYFDKLYELAEELIKRDKAYVCHCTD---AEIKKARGGEERgpryACVHRDrpiEES 389 fission yeast 6686013 125 AYDLIRQDLKWLGVSWDEEYIQSLRMEVFYSVARRAIERGCAYVDNCGRe--GKELLSRGEY-------CPTRDlgpEDN 195 Aeropyrum pernix 2500977 142 AYDMIKEDLDWLGVKVDEVVIQSDRIELYYEYGRKLIEMGHAYVCDCNP---EEFRELRNKGV-----PCKCRDraiEDN 213 Methanocaldococcus ... 20094194 149 AYDMIEEDLEWLGVNIDERYVQSNRIELYYMVCEELLEREGAYVCTCDP---DEFRRLRDVGR-----ACPCRSrdkEEN 220 Methanopyrus kandle... 3334350 147 AYDMIPADLEWLGVEWDETVIQSDRMETYYEYTEKLIERGGAYVCTCRP---EEFRELKNRGE-----ACHCRSlgfREN 218 Methanothermobacter... 13878788 152 FYEMIIEDLEWLGIKPDEIVYASDRLELYYKYAEELIKMGKAYVCTCKP---EKFRELRDKGI-----PCPHRDepvEVQ 223 Pyrococcus abyssi 18313726 157 AYESIREDLRWLGVRWDEEYIQSQRMEIYYEHAKKLLEMGAAYVDLCKP---EEWRRLRNEKK-----ACPHREqppEVN 228 Pyrobaculum aerophilum 6686004 151 FYKMIIEDLEWLGIKPDEIVYASDRLEIYYKYAEELIKMGKAYVCTCPP---EKFRELRDKGI-----PCPHRDepvEVQ 222 Pyrococcus horikoshii 2500979 154 AYDWIKEDLKWLGIKWEQELYASERLELYYKYARYLIEKGYAYVDTCDSsifRKFRDSRGKMKEp---ECLHRSsspESN 230 Sulfolobus solfatar... 13541917 146 AYAMIPEDLEWLGVNVTKTVIQSERFDLYYSVAKKLIENGHLYICTCDR---EEFKRKKLASI-----PCKDRDnppETN 217 Thermoplasma volcanium
11387159 390 LLEFRNMRDGKyqPKEAILRMKQDLSDGNPQMWDLIAYRVLNSP-HPR--TGDKWKIYPTYDFTHCLVDSFENISHSLCT 466 fission yeast 6686013 196 LELFEKMLEGEfyEGEAVVRMKTDPRHPNPSLRDWVAMRIIDTEkHPHplVGSRYLVWPTYNFAVSVDDHMMEITHVLRG 275 Aeropyrum pernix 2500977 214 LELWEKMLNGEleN--VAVRLKTDIKHKNPSIRDFPIFRVEKTP-HPR--TGDKYCVYPLMNFSVPVDDHLLGMTHVLRG 288 Methanocaldococcus ... 20094194 221 LELWEEMLDGTfsEGEAVVRVKTEVDHPDPAVREWIAFRIVEEE-HPM--TGSRYLVWPTMNFAVAVDDHLMNITHVLRG 297 Methanopyrus kandle... 3334350 219 LQRWREMFEm--kEGSAVVRVKTDLNHPNPAIRDWVSMRIVEAE-HPR--TGTRYRVYPMMNFSVAVDDHLLGVTHVLRG 293 Methanothermobacter... 13878788 224 LERWRKMLNGEykEGEAVVRIKTDLNHPNPAVRDWPALRIVDNPnHPR--AGNKYRVWPLYNFASAIDDHELGVTHIFRG 301 Pyrococcus abyssi 18313726 229 LELWDKMLEGRfkEGEAVLRIKTDLTHPDPSVRDWVAFRIIDTSkTPHplTGDKYIVWPTYNFAVSIDDHLMGVTHVLRA 308 Pyrobaculum aerophilum 6686004 223 LERWKKMLNGEykEGEAVVRIKTDLNHPNPAVRDWPALRIIDNPnHPR--TGNKYRVWPLYNFASAIDDHELGVTHIFRG 300 Pyrococcus horikoshii 2500979 231 LELFEKMLGGKfkEGEAVVRLKTDLSDPDPSQIDWVMLRIIDTAkNPHprVGSKYWVWPTYNFASIIDDHELGITHVLRA 310 Sulfolobus solfatar... 13541917 218 LYLFEKMLDGEikAGAAVAVMKTDLNHPNPSVRDWIAFRIIDAK-HPR--TGDKYRVFPMMSFSVAVDDHYLGLTHVLRG 294 Thermoplasma volcanium
11387159 467 TEFILSRVSYEWLCNALEVYcPAQREYGRLNVvGTLMSKRKImkLVKEG--YVHGWNDPRLYTLVALRRRGVPPGAILEF 544 fission yeast 6686013 276 KEHQLNTEKQLAVYRCMGWRpPYFIHFGRLKLeGFILSKSKIrkLLEERpgEFMGYDDPRFGTIAGLRRRGVLAEAIRQI 355 Aeropyrum pernix 2500977 289 KDHIVNTEKQAYIYKYFGWEmPEFIHYGILKIeDIVLSTSSMykGIKEG--LYSGWDDVRLGTLRALRRRGIKPEAIYEI 366 Methanocaldococcus ... 20094194 298 KDHESNTRRQKYVFEHLGWDtPEYVHYGILKVeGAVLSTSEIrrGIDSG--EYTGWDDVRVATLRALRRRGIKPEAIRET 375 Methanopyrus kandle... 3334350 294 KDHLANREKQEYLYRHLGWEpPEFIHYGRLKMdDVALSTSGAreGILRG--EYSGWDDPRLGTLRAIARRGIRPEAIRKL 371 Methanothermobacter... 13878788 302 QEHAENETRQRYIYEYFGWEyPVTVHHGRLSIeGVILSKSKTrkGIEEG--KYLGWDDPRLGTIRALRRRGILPEAIKEL 379 Pyrococcus abyssi 18313726 309 QEHSVNTIKQSYVFRHFGWEqPVTIHFGRLRIeGATLSKSKLkaMRIKY----DDLTLP---TLAGLRNRGIVPEAIWDL 381 Pyrobaculum aerophilum 6686004 301 QEHAENETRQRYIYEYFGWEyPVTIHHGRLSIeGVVLSKSKTrkGIEEG--KYLGWDDPRLGTIRALRRRGILPEAIKEL 378 Pyrococcus horikoshii 2500979 311 KEHMSNTEKQRYISEYMGWEfPEVLQFGRLRLeGFMMSKSKIrgMLEKG----TNRDDPRLPTLAGLRRRGILPDTIKDV 386 Sulfolobus solfatar... 13541917 295 KDQLTNTEKQRYVFEYNGWNkPYYYHYGMIRFpGTRLKTSLMkkGIQAG--QYDGWSDVRLGTVRAMARRGYQPETFRRY 372 Thermoplasma volcanium
11387159 545 VSEVGVTTAVSNIEVARFENCVRKFLENSVPRLMFLpDPIKVTLENLDDsYREQIEIPFnpkDPSMGSRSAFLTK----- 619 fission yeast 6686013 356 ILEVGVKPTDATISWANLAAANRKLLDERADRIMYVeDPVEMEVELAQV-ECRAAEIPFhpsRPQR-KRRITLCTg---d 430 Aeropyrum pernix 2500977 367 MKRIGIKQADVKFSWENLYAINKELIDKDARRFFFVwNPKKLIIEGAE--KKV-LKLRMhpdRPEFGERELIFDG----- 438 Methanocaldococcus ... 20094194 376 ILEIGLTDVDATFSWEHLYARNRKMIDPESHRYFFVrDPVELRIEGMK--ESVLARLPLhpdRDE-GERVLILHPengva 452 Methanopyrus kandle... 3334350 372 MVEIGVKIADSTMSWKKIYGLNRSILEEEARRYFFAaDPVKLEVVGLP--GPVRVERPLhpdHPEIGNRVLELRg----- 444 Methanothermobacter... 13878788 380 IIEVGLKKSDATVSWDNLAAINRKLVDPIANRYFFVaDPVPMEVEGAP--EFI-AKIPLhpdHPERGTRELRFTPg---k 453 Pyrococcus abyssi 18313726 382 ILSVGIKPSDSTVALANLFAFNRKHIEPIADRYMYVaDPVKLVFEAD---KELTAHVPFhpsFKERGERTYRLGPgr--v 456 Pyrobaculum aerophilum 6686004 379 IIEVGLKKSDATISWENLAAINRKLVDPIANRYFFVaDPIPMEVEGAP--EFI-AEIPLhpdHPERGVRRLKFTPe---r 452 Pyrococcus horikoshii 2500979 387 IIDVGVKVTDATISFENIAAINRKKLDPVAKRIMFVkDAEEFSVELP---ESLNAKIPLipsKQEM-NRTIIVNPg---d 459 Sulfolobus solfatar... 13541917 373 WINSGLREIDAVFSWEIFNSLNREFVDPKAYRFSFTkDPVEIKMEGS---NGLTARLPYhpsHPEYGVRKYEIGd----- 444 Thermoplasma volcanium
11387159 620 HIYIDRSDFREEASSdffrltlgQPVGLFRASHPVVAKRVVKNDEGEPIEiiaeydASSSKkpktFIQWVSRDKesnspv 699 fission yeast 6686013 431 KVLLTREDAVEGR-----------QLRLMGLSN---FTVSQGILREVDPSle--yaRRMKLp---IVQWVKKGGe----- 486 Aeropyrum pernix 2500977 439 EVYVVGDELEENK-----------MYRLMELFNIVVEKV-DDIALAKYHSddfkiaRKNKAk---IIHWIPVKDs----- 498 Methanocaldococcus ... 20094194 453 RALLDGEDAEDLWEG--------DVVRLMNAVNVEIEEVGDGWLRGRYHSddyriaKEEGAq---IVHWVPPDQa----- 516 Methanopyrus kandle... 3334350 445 EVYLPGD---DLGEG---------PLRLIDAVNVIYS---GGELR--YHSegieeaRELGAs---MIHWVPAESa----- 499 Methanothermobacter... 13878788 454 PIYVSKDDLDLLKPG--------SFVRLKDLFNVEIVEV-GEKIKAKFHSfeyeiaRKNKWr---MIHWVP--Eg----- 514 Pyrococcus abyssi 18313726 457 EVYIQRRDAVAGK-----------VVRLMELANVEIVRVEGDVAYGRIHSysldeaKKIGAp---IIQWVWDP------- 515 Pyrobaculum aerophilum 6686004 453 PVYVSKDDLNLLKPG--------NFVRLKDLFNVEILEV-GDKIRARFYSfeyeiaKKNRWk---MVHWVT--Eg----- 513 Pyrococcus horikoshii 2500979 460 KILIESNDAEDNS-----------ILRLMELCN---VKVDKHNRKLIFHSktldeaKKVNAk---IVQWVKSNEk----- 517 Sulfolobus solfatar... 13541917 445 TVYISKGDADKIADG--------ERFRLKDLCYVV-----RKGDRFLFDGt----eMKEKTk---IINWCP-PNs----- 498 Thermoplasma volcanium
11387159 700 liaetrlfnNLFKCDNPaalkeqelaaQLNPesEVVLKnSIIEPGIyDLIKSAPwpktdssagvdkaenpesvrFQAMRV 779 fission yeast 6686013 487 ---------ASVEVLEPv---------ELEL--RRHQ--GYAEDAI-RGYGVDSr-------------------LQFVRY 524 Aeropyrum pernix 2500977 499 ---------VKVKVLMP----------DGE-----IKE-GFAEKDF-AKVEVDDi-------------------IQFERF 533 Methanocaldococcus ... 20094194 517 ---------VRCEVVRP----------DGS-----VES-GYAEINV-EREQAGSt-------------------VQFERL 551 Methanopyrus kandle... 3334350 500 ---------LEAEVIMP----------DAS-----RVR-GVIEADA-SELEVDDv-------------------VQLERF 534 Methanothermobacter... 13878788 515 ---------RPCEVIIP----------EGDE--LIVRK-GLLEKD--ANVKAGEi-------------------VQFERF 551 Pyrococcus abyssi 18313726 516 ---------VEITVIKPa---------GVGR--KEVEV-GLGEGWL-ERVEVGKy-------------------VQFFRY 554 Pyrobaculum aerophilum 6686004 514 ---------RPCEVIIP----------EGDE--LVVRK-GLLEKD--AKVQVNEi-------------------VQFERF 550 Pyrococcus horikoshii 2500979 518 ---------VPVMVEKAe---------RDEI--KMIN--GYAEKIA-ADLEIDEi-------------------VQFYRF 555 Sulfolobus solfatar... 13541917 499 ---------REFQVLKP----------DGS-----IDK-GLIEPA---SKGYRGi-------------------SQLERY 531 Thermoplasma volcanium
11387159 780 GYFCLD 785 fission yeast 6686013 525 GFVRVD 530 Aeropyrum pernix 2500977 534 GFVRID 539 Methanocaldococcus jannaschii 20094194 552 YFVRLE 557 Methanopyrus kandleri AV19 3334350 535 GFARLD 540 Methanothermobacter thermautotrophicus 13878788 552 GFVRID 557 Pyrococcus abyssi 18313726 555 GYLKKR 560 Pyrobaculum aerophilum 6686004 551 GFVRID 556 Pyrococcus horikoshii 2500979 556 GFVRVD 561 Sulfolobus solfataricus 13541917 532 GYVNFY 537 Thermoplasma volcanium
Jiyao W et al.(2023). "The conserved domain database in 2023.",