19114260 58 DESAAQQWVYPINVSFRDYQFNIVQKALFE--NVLVALPTGLGKTFIAAVVMMNYLRWFPKsYIVFMAPTKPLVTQQMEA 135 fission yeast 11499053 1 MEYVTHPLIKENTIERRMYQISIAATALTK--NTLVVIPTGLGKTTIAALVIASRLLNEDG-KVLFLAPTKPLVEQHARF 77 Archaeoglobus fulg... 20088995 1 ---MKHPLIKPDTVEQRLYQLNLAGKALEG--SSLVVLPTGLGKTIIALFVIASRLQRFGG-KALILSPTKPLVDQHAAF 74 Methanosarcina ace... 3915469 1 -MFIEHPLIKPKTLEARLYQQIIAANALKK--KTLCVLSTGLGKTAIAILVIAGILTKKDG-KVLILAPSRPLVEQHYNR 76 Methanocaldococcus... 20095114 1 --MPAWRRVNWNFLERREYQVSVAAEILDSmdNTLVVIPTGLGKTAIGVMVLS-ELVDEGR--AVFLAPTVPLVNQHARF 75 Methanopyrus kandl... 15679414 2 ARYIEHPLIKPEKIEARTYQQLLAADVIRKg-NSMIVAPTALGKTVVAVLVAAERLRKYRGsKVLILSPSKPLAIQHEES 80 Methanothermobacte... 14520497 1 ---MNTMYLRKELLQPRLYQELIYAKCKER--NCLIVLPTGLGKTIIAMMIADYRLNKYGG-KVLMLAPTKPLVLQHAET 74 Pyrococcus abyssi 14591755 1 ---MNLMYIRKDLLQPRLYQELIYAKCKER--NCLIVLPTGLGKTIIAMMIADYRLDKYGG-KVLMLAPTKPLVLQHAET 74 Pyrococcus horikoshii 19114536 96 NIDAMQNWIFPQTQQYRNYQKEFCEQALFH--NLLLALPTGLGKTFIAAVVMLNYFRWFPEsKIIFLAPTKPLLLQQRVA 173 fission yeast 13542321 1 ------MLVN---IEPREYQINVYKNSIDK--NTLIVMPTGLGKTLIAAMLIEKFFKENKK--SIFLAPTKPLVLQHMAT 67 Thermoplasma volca... 16082461 1 ------MII-----QPREYQLNVFKNSIGQ--NTLIVMPTGLGKTIIAAMFIEKFYGEKKR--SLMVAPTKPLVLQHART 65 Thermoplasma acido... 15791152 5 MGYVDHPMLADGVIEARQYQLQLAAAARQG--HTLVCLPTGLGKTTVSLLVTAYRLADDAGgTALLLAPTKPLVEQHAGF 82 Halobacterium sp. ... 731905 72 DYDALSFYVYPTNYEVRDYQYTIVHKSLFQ--NTLCAIPTGMGKTFIASTVMLNYFRWTKKaKIIFTAPTRPLVAQQIKA 149 baker's yeast
19114260 136 CYKITGIPKSQTAELSGHVPVTTRNQYYQSRNVFFVTPQTILNDIKHGICDRTRISCLVIDEAHRSTGNYAYVEVVHLLS 215 fission yeast 11499053 78 LKRVLKV--EEIVSLSGEVPPEKRKELWEKARIVVSTPQVVENDLLAGRISLEDVILVVFDEAHRAVGNYAYVFIAKEYL 155 Archaeoglobus fulg... 20088995 75 FKKVMALPEEEILAFTGSIAPAEREKLWAQGKLIVSTPQVIENDLLTKRISLEDVSHITFDEAHRAVGNYAYTFIAEKYF 154 Methanosarcina ace... 3915469 77 LKQVLNIDEDKIIALTGKIQPKKRAELYKKGKIFIATPQVIENDIIAGRINVDEFILLIADEAHHTTGDHAYAFVAK-KF 155 Methanocaldococcus... 20095114 76 IERATRG--LDVKALTGRVRPERRKVEWKKSDVIVATPHVIRNDIIEGRIDPDEASVVIFDEAHRAVGGYPYVYVSK--- 150 Methanopyrus kandl... 15679414 81 FREFMLATCT---SLTGSIKPEERKERWIKSQIISATPQTVESDILAGRYDLRDVSLIVFDECHRAVGSYSYVFLASNYI 157 Methanothermobacte... 14520497 75 FRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYL 154 Pyrococcus abyssi 14591755 75 FRKFFTLPPEKIVALTGEISPNERVRAWARAKVVIATPQTIENDLLVGRISLEDVTLIIFDEAHRAVGNYAYVYIAKEYL 154 Pyrococcus horikoshii 19114536 174 CSNVAGMSPGATAELNGEVSPDRRLFEYNTKRVFFMTPQTLQNDLKEHLLDAKSIICLIFDEAHRATGNHSYAQVMRAVL 253 fission yeast 13542321 68 LVKVLGLNNNEICAFTGEVDSQERELRWVTGKIFVSTPQVVLNDMKSGIIDITRFDLIVFDEAHRAVGNYAYVDIASEFL 147 Thermoplasma volca... 16082461 66 IADSTGISENEIGVFTGEIDAEERELIWVTKKIFVSTPQVVFNDMRSGILDITKFDLIIFDEAHRAVGNYAYVDIAQEYL 145 Thermoplasma acido... 15791152 83 YREALAIPDDDVVVFTGETRPDDRRAAWTDARVVVATPQVVENDLVGGRIDMDDVVHCTFDECHRATGDYAYTYVAERYH 162 Halobacterium sp. ... 731905 150 CLGITGIPSDQTAILLDKSRKN-REEIWANKRVFFATPQVVENDLKRGVLDPKDIVCLVIDEAHRATGSSAYTNVVKFID 228 baker's yeast
19114260 216 LSNKNFRILALSATPGNKLEAIQNVIDSLHISRIEIRTENSIDISQYVQKKEVDFFPVDLSAEITDIRDRFSSILEPMLQ 295 fission yeast 11499053 156 RTAKKPLILAMTASPGSDPERIMEVIQNLGIEAIEVRTEWDSDVAPYVGKKRIEWIKVDIPEEMKEVKERLKECIKIRFK 235 Archaeoglobus fulg... 20088995 155 ESAKNPHILGITASPGSSDEKIAEVCQALHVENVAVKTEKDRDVRPYVQEKEIEWLQVQLPPEMAEIRSYLEKILDDRLR 234 Methanosarcina ace... 3915469 156 KDKCH--ILGLTASPGSDIDKVMEICENLGIEHVEVRTEDDEDVKPYIAKVKLIPIRIDLPNEFKRALKLINEALKERLK 233 Methanocaldococcus... 20095114 151 --EFNCLKVGLTASPGSDVKRIKEVVQNLGIERIIVKTEEDPDVKKYLGRVKVEWVDVELPEWFDNARRELQRAFERRLE 228 Methanopyrus kandl... 15679414 158 QNARHPLILGLTASPGADEDKIKTVCENLFMNEVVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLKNRLK 237 Methanothermobacte... 14520497 155 NQAKNPHVIGLTASPGSSQEKILEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLK 234 Pyrococcus abyssi 14591755 155 KQAKNPHVIGLTASPGSTPEKIMEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWVKVELPELYKEVRKLLRDMLRDSLK 234 Pyrococcus horikoshii 19114536 254 RSNSHFRVLGLTATPGSSTASVQKVVDCLHISKLIVRNEESIDIRSYVFHKKIQLIKVTISSEMNILKSDFANLYRPYFN 333 fission yeast 13542321 148 EYKKK-LIIGLTASPGGEKGRFQEIVKNLGIENVVVKTEKDEDVRKYIKSIEMHLIKLKEPDQCGAIKDLLKSALDSVLK 226 Thermoplasma volca... 16082461 146 KYKKK-LIIGLTASPGSSREKIDEIMANLGISKVIAKTEMDEDVRKYVKTIDVKLIKIREPDGTKEIVNMIDAVMSKLLE 224 Thermoplasma acido... 15791152 163 ADAAAPLVTAMSASPGGTEAEIRTVCENLGVGNVEVMTEDDADVGEHTHDTDVQWERVTLPEEILEVRDAINDVIEDRLA 242 Halobacterium sp. ... 731905 229 RFNSSYRLLALTATPASDLEGVQEVVNNLDISKIEIRTEESMDIVKYMKKRKKEKIEVPLLLEIEDIIEQLGMAVKPVLQ 308 baker's yeast
19114260 296 KLNKGNYYRIQN--AKDITSFTVVqakQAFLAMSgQNFpANQKWDILNTFDALATFAYPLNLLLNHGIRPFYQKLR-EVE 372 fission yeast 11499053 236 RLRELWIEVPEN--SSKRDLLALQe--ALQAEAA-SSQ-SSEIFEALSILAEIMKLQHAVELIETQGVKAVKSYLR-KLV 308 Archaeoglobus fulg... 20088995 235 IIKDLGFSAGSGkyISKKDLLLLQk--QLQGEIR-VGG-DPAIFSAMSVVAEMMKVNHAVEMVETQGLETLRKYLE-KLD 309 Methanosarcina ace... 3915469 234 ILKDAGVINSIAd-VTKTELIELN----NKLF---SYD-EEVKYELIKVCSEALKLMHAKELLESQGKSVFLNYIN-KLS 303 Methanocaldococcus... 20095114 229 LLEDMGFLQSSRn-VWVGKLLSLRe--EIREQMAkRRErASWCSRALGVVAEALRIARAREILETQGIEPFLRYVE-RLT 304 Methanopyrus kandl... 15679414 238 MLKNLGVIDTIS--VGKKDLLKARgrvQNRIARS-TSP-PRACYRAISLLASCINVEHALELLETQGIRPLHQYLL-RLK 312 Methanothermobacte... 14520497 235 PLAEAGLIESASadLPKKEILRAGq--IINEETA-KG--NHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYLK-KLY 308 Pyrococcus abyssi 14591755 235 PLAEAGLLDSTSadIPKKEILRAGq--IINEEMA-KG--NHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYLK-RLY 308 Pyrococcus horikoshii 19114536 334 FLRQKKLIPINCecLNIKAYTLFVs--LRKYSFSsKNVqSKEKSKIMSCFTLLISCAHITYLLDCHGIIQFYQKLV-ETK 410 fission yeast 13542321 227 PLKDQGIKVGRT----RKDMAESI----QNLINR-AKE-DRSLFPLVRHLTAAIRIDYIIEYIETQGLDVAYQYVK-DME 295 Thermoplasma volca... 16082461 225 PVKSSNFSIGRS----RKDLVATM----QKVINS-AKE-DRSLFQLVRRITAAIRLDYLKEYIETQGIDVALHYLE-EME 293 Thermoplasma acido... 15791152 243 KLREIGVTKASSpdISQKDLNEIR----ARLQQL-IDDdDSDGYQGMSVHAEVMKLKRAVELVETQSVESVRRYFE-RQR 316 Halobacterium sp. ... 731905 309 QAIELGIYEECDp--SQINAFKAMq--QSQKIIAnPTIpEGIKWRNFFILQLLNNVGQMLKRLKIYGIRTFFNYFQnKCT 384 baker's yeast
19114260 373 EECFVgRSGYKKRIINHENYRPLMDDIEI-----LLrDQSFVGHPKLEHLERIVTEYFEKEQTk--dTRIMIFVEIRSSA 445 fission yeast 11499053 309 REATSkGGSKAAKSIVGDPIFKKA---VI-----AL-SKCKVEHPKLEKLKEILKEQFEKNPD----SRVIVFTNYRDSA 375 Archaeoglobus fulg... 20088995 310 SEASSkSASKAAKRLMDDLYMRKA---LY-----RV-KECDVEHPKLELARKIVSEQLKKNPD----SRVIVFTNYRDTA 376 Methanosarcina ace... 3915469 304 MQRTK---S--AKSIVNDEKVREAVNLL---------MKSDVEHPKLGKVVDMVKNILEKNKD----ERIIIFAQYRDTV 365 Methanocaldococcus... 20095114 305 ERKRSsGGS-SLRRILGDPNFQRAVRECK-----SAsLRDEPDHPKLPEVEELVKDVE----------SALVFTQYVDTA 368 Methanopyrus kandl... 15679414 313 EKKTK---A--AKGLLADPDFTRAMHLTR-----RA-MMSGVEHPKLDRLMEILKREL-KGDE----ARIIVFTQFRDTL 376 Methanothermobacte... 14520497 309 EEAKT-GSTRASKELFLDRRMKKALALLI-----QA-KELGIDHPKMEVLKELVKEQLSKKEN----SKIIVFTNYRETA 377 Pyrococcus abyssi 14591755 309 EEAKA-GSTRASKELFLDKRMKKALALLI-----QA-KELGIDHPKMEVLKGLIREQLKRKEN----SKIIVFTNYRETA 377 Pyrococcus horikoshii 19114536 411 NKAEG-KGSGQSFWLFTSKPFAFYLEHLH-----NKiQGLSLNHPKMNHLLELLKEHFKDTSEgyqnQRVMIFTEFRNTA 484 fission yeast 13542321 296 ESQDQ--SIKRAYSMMKSLDDFRKAIENM-----KN-VLPGYRNPKMMKVLEICQEKV--IAG----ERAIVFTHFRATS 361 Thermoplasma volca... 16082461 294 KSQDP--GIRRAISMLSSLDEFATLRTKL-----ML-AADGYTNPKMEKTLSIMESNV--HGN----ARAIVFTHYRITS 359 Thermoplasma acido... 15791152 317 NAANTaGASKASQRLVSEPAVKRA--MR------TA-REFDGLHPKFRQARMLLAETLGIEDG----DRVIVFTESRDTA 383 Halobacterium sp. ... 731905 385 EFTTKyNLKKSTNKIAAEFYYHPILKNIKnqcenYLsDPKFVGHGKLQCVRDELMDFFQKRGSd---SRVIIFTELRESA 461 baker's yeast
19114260 446 EEILRFLGKFYPNVRp-AIFIGQS-----------AVRKA---------------------------------------- 473 fission yeast 11499053 376 EMLVNELSPLFPVA----KFVGQA-----------SRDND---------------------------------------- 400 Archaeoglobus fulg... 20088995 377 EIVANALSGFSGIIP--IRFVGQG-----------SRNKN---------------------------------------- 403 Methanosarcina ace... 3915469 366 EKIVNLLTQNGIKAI---RFIGQA-----------NKEG----------------------------------------- 390 Methanocaldococcus... 20095114 369 KLIADYLKEIGISVG---VLLG--------------KEH----------------------------------------- 390 Methanopyrus kandl... 15679414 377 EEIYQRCKREGINAV---KFYGQN-----------SRSGE---------------------------------------- 402 Methanothermobacte... 14520497 378 RKVVEELTKEGIKAK---RFVGQA-----------TKEND---------------------------------------- 403 Pyrococcus abyssi 14591755 378 KKVVEELMKDGIKAR---RFVGQA-----------SREND---------------------------------------- 403 Pyrococcus horikoshii 19114536 485 EYITTTLLAIRPMVRa-SLFIGQA-----------NSAYS---------------------------------------- 512 fission yeast 13542321 362 DMLLAYLKNSSDKIKp-VRFIGQA-----------DRGTD---------------------------------------- 389 Thermoplasma volca... 16082461 360 DLLMDYIQKNGTSLKp-VRFIGQA-----------DRGSD---------------------------------------- 387 Thermoplasma acido... 15791152 384 EALTAFLGEHFDTR----RFVGQG-----------DADGS---------------------------------------- 408 Halobacterium sp. ... 731905 462 LEIVKFIDSVADDQIrpHIFIGQArakegfdevkyTRKHApkgrkkverlhrqeqekfleaertkraandklersarrtg 541 baker's yeast
19114260 474 -------AGMSQKLQNETVKQFQKGEVNTLIATSIGEEGLDIGEVDMIICYDASASPIRMLQRMGRTGRK-RKGYIYMLL 545 fission yeast 11499053 401 -------KGMRQKEQIETIDKFRRGVYKVLVATSVGEEGLDIPSTDLVVFYEAVPSEIRAIQRKGRTGRG-REGRIVVLV 472 Archaeoglobus fulg... 20088995 404 -------KGLTQKQQAEILDKFRAGEYNVLVATSVAEEGLDIPATDMVLFYEPIPSEIRSIQRKGRTGRQ-QKGRVIVLV 475 Methanosarcina ace... 3915469 391 -------KGMSQKEQIEAIERFKK-EGSVLVSTSVSEEGIDIPSVNYIIFYEPVPSEIRFIQRRGRAMRG-EGGKVYVLI 461 Methanocaldococcus... 20095114 391 ---------MKEHEQLDVIKSIKRGECRVLVSTSVGEEGLDLPTCEEVVLYEPVPSEIRTIQRIGRTARDgAVGNAHVLV 461 Methanopyrus kandl... 15679414 403 -------KGLTQKQQRDIIKSFRMGNHDVLLSTSVAEEGIDIPSVDLVVMYEPVPSEIRMIQRRGRTGRK-RKGRMVVLI 474 Methanothermobacte... 14520497 404 -------RGMSQREQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQ-KPGRVVILI 475 Pyrococcus abyssi 14591755 404 -------RGMSQKEQKLILDAFARSEFNVLVATSVGEEGLDVPEVDLVIFYEPVPSAIRSVQRRGRTGRQ-KPGRVVILM 475 Pyrococcus horikoshii 19114536 513 -------TGMNQMQQKETIDQFRAGVINTLVATSIGEEGLDIGDTDMIICYDASSSPIRTIQRMGRTGRK-KSGKVFVLL 584 fission yeast 13542321 390 -------VGLSQEEQRQIIEQFRNGTYNVLIATSIAEEGLDIPDTDVVVFYEAVPSEIRFIQRKGRTGRS-RSGEVYILV 461 Thermoplasma volca... 16082461 388 -------EGLSQDQQKKIIEDFKNNVYNVLIATSIAEEGLDIPDTDFVIFYEAVPSEIRYIQRKGRTGRS-RNGQVYILV 459 Thermoplasma acido... 15791152 409 -------DGMTQTEQRETLAEFRNGDFEVLVSTSVAEEGLDVPEVDLVLFFEPVPTAIRSVQRKGRTGRQ-TAGRVVVLL 480 Halobacterium sp. ... 731905 542 sseeaqiSGMNQKMQKEVIHNFKKGEYNVLVCTSIGEEGLDIGEVDLIICYDTTSSPIKNIQRMGRTGRK-RDGKIVLLF 620 baker's yeast
19114260 546 TRGk-eEAKWERAKDAYRTLQDNIVSGRGLSLSEKSYriLPEKFRPVCDKRVIEIPKENEEVVVAPKKV 613 fission yeast 11499053 473 TKG---TRDEAYYYSSMKKERKMYDKILEIKRIID------RKQRSIGDYV-LPEETGIKVIVDSRELR 531 Archaeoglobus fulgidus 20088995 476 TKG---TRDEAYYWSSKNKEKRMLKSMHGLETALTPK--VSKKSAALSDFENLPCTPDPQLKTEKIEIE 539 Methanosarcina acetivorans C2A 3915469 462 AKG---TADEAYYRSALYKEREMKRLLKNMCYLLNKR--LQKKFEEKSK-EEIKEETEEIKEKEIESKT 524 Methanocaldococcus jannaschii 20095114 462 ARGsfpTLDEIYFHVARRREKKMLEAVMRVQEWLRKR--KGKTTATSKNLRKLRSRAKTLDQFVGGGRS 528 Methanopyrus kandleri AV19 15679414 475 TEK---TRDEAYYYSSIRKERSMKENLRGGS--VNVE--VNPIMEPSGEGPFIYADSREVNsrvlrelk 536 Methanothermobacter thermauto... 14520497 476 AQG---TRDEAYYWSSKHKERQMRETIRMVSQAIK-------REKQLslesyvkkdtekemereekeer 534 Pyrococcus abyssi 14591755 476 AQG---TRDEAYYWSSRQKEKIMRETIRMVSQMVR-------KERQLslesyvkrevneeikeekketg 534 Pyrococcus horikoshii 19114536 585 TEDc-eDSKWERSQVSYRRVQKVIESGKKIALKKDVPrlIPSNIQPIFKFQALQNNADATLILNSYNNN 652 fission yeast 13542321 462 YEN---SRDMAYYYRSLKKVSMMNRNIMEYRDEHPYT--KNERQENSNNGQRTIFDF------------ 513 Thermoplasma volcanium 16082461 460 FEN---SRDMAYYYSSIRKVSRMTQTIEDLRQES--G--SDEKEEKSD-VQKTIFDF------------ 508 Thermoplasma acidophilum 15791152 481 AED---TRDEAYFWISRRREQEMTEELQSLKGRAD-----ELETELGGDGAQQALDEFGDAEAAGEEPA 541 Halobacterium sp. NRC-1 731905 621 SSN-----ESYKFERAMEDYSTLQALISKQCIDYK-------KSDRIIPEDIIPECHETLitindenei 677 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",