1AOA,1AA2,1QAG,1DXX


Conserved Protein Domain Family
CH
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cd00014: CH (this model, PSSM-Id:237981 is obsolete and has been replaced by 409031)
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Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).
Links
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Statistics
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PSSM-Id: 237981
Aligned: 53 rows
Threshold Bit Score: 59.6319
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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putative actin
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative actin binding surface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      ## ###  #  #                                                                    
1AOA        24 EEKYAFVNWINKALEndpdcrhvipmnpntdDLFKAVGDGIVLCKMINLSVPDTIderaink---------------kkl 88   human
6225157     27 QAEEDLRNWIEEVTGmsi-----------gpNFQLGLKDGIILCELINKLQPGSVkkvne------------------ss 77   human
2494862      2 EQWRQCGRWLIDCKVlppnhrvv-wpsavvfDLAQALRDGVLLCQLLHNLSPGSIdlkdinf--------------rpqm 66   house mouse
1723270     65 CSVHEAKKWLEEETNneyq---------nldDFVDALVNGKVLCQLAFKYYPKLAsnwkpr-----------------yq 118  fission yeast
7497065      6 DLWIGCARWLRDMKVlttdk------ngtmlEFASVLRDGILLCRLANTLVPNGIdqkkimr--------------tnqp 65   Caenorhabditis e...
3023836     28 AMKEDLAEWLNALYGlglp--------gggdGFLTGLATGTTLCQHANAVTEAARalaaarpargva-----fqahsvvp 94   human
1170586     45 CHLEEAKRWMEACLGedlp---------pttELEEGLRNGVYLAKLGNFFSPKVVslkkiydreq--------trykatg 107  human
6325014    109 CRVSEVKIWIEAVIEealps-------eielCVGDSLRNGVFLAKLTQRINPDLTtvifpa----------------gdk 165  baker's yeast
1841843     25 ESEAEAINWLNQLTNenvp--------fgreNVAAASKNGQISIKLINVVFDGTAslpsaaakmkr------pfkantmt 90   Schistosoma mansoni
120945      36 PMKEDLALWLTNLLGkei----------taeTFMEKLDNGALLCQLAATVQEKFKesmdankpaktlplkkipckasaps 105  house mouse

Feature 1                  ##  #   # #                ##  ## ##  ##  
1AOA        89 tpfIIQENLNLALNSASa-IGCHVv-nIGAEDLr-aGKPHLVLGLLWQIIKIGL 139  human
6225157     78 lnwPQLENIGNFIKAIQa-YGMKPhdiFEANDLfenGNMTQVQTTLVALAGLAK 130  human
2494862     67 sqfLCLKNIRTFLKVCHdkFGLRNselFDPFDLfdvRDFGKVISAVSRLSLHSI 120  house mouse
1723270    119 iseRNTVYLNAFFHFLDf-IGMFTpfrFETKDLvrrFNIPKVIYCLHALSYLLD 171  fission yeast
7497065     66 spfLCCNNINYFAMFCKtyFNLEDadlFTAEDLyymNGFQKVLKTLSFLSHTKE 119  Caenorhabditis elegans
3023836     95 gsfMARDNVATFIGWCRveLGVPEvlmFETEDLvlrKNEKSVVLCLLEVARRGA 148  human
1170586    108 lhfRHTDNVIQWLNAMDe-IGLPKifyPETTDI---YDRKNMPRCIYCIHALSL 157  human
6325014    166 lqfKHTQNINAFFGLVEh-VGVPDsfrFELQDLynkKNIPQVFETLHILISMIN 218  baker's yeast
1841843     91 aplNRWKIIQTFLNAAVa-YGVPRaslFQTVDLyelRNMPQVLNTLLQLGTECQ 143  Schistosoma mansoni
120945     106 gsfFARDNTANFLSWCRd-LGVDEtclFESEGLvlhKQPREVCLCLLELGRIAA 158  house mouse

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