1VHR,1MKP


Conserved Protein Domain Family
DSPc
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cd00127: DSPc (this model, PSSM-Id:238073 is obsolete)
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Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or Cdc25-like.
Links
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Statistics
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PSSM-Id: 238073
Aligned: 51 rows
Threshold Bit Score: 117.71
Created: 16-Aug-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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active site catalytic
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           #         
1VHR_A     28 PCNEVTPRIYVGNAsvaqdipKLQKLGITHVLNAaegrsfmhvn-------tnanfykdsGITYLGIKANDTq--eFNLS 98  human
CAC32252  294 PMSDITSLLAVGSWkdasnpeLLKAHNIRYVLNVakeliptee---------akliaqnnDIVSEWIPMNDSh--tQDVS 362 Leishmania major
1709121   234 PLLVLPPNLYLYSEp-----kLEDILSFDLVINVakeipnle-----------flippemAHKIKYYHIEWTh--tSKIV 295 baker's yeast
T39517     61 PVCIYPPNIYLYAKp-----tMPIIQSFDVVINVakevlhpfrtdgrhyrdskhnldiqvFDHIEYVHIHWDh--dTQFA 133 fission yeast
9631873    24 KPKKITNHVWVGSEataadpaFLKKNNIKLVVNCtadi------------------pkysNIPMLRVPVHDAafdaDKMA 85  Paramecium bursari...
P80994     26 MMTRVTNNVYLGNYkna-meaPSSEVKFKYILNLtmdky----------------sftnsNINIIHVPMVDDt--sTDIS 86  Raccoonpox virus
1172738   429 PKNVLNNLIYLYSDpa---qgKIDINKFDLVINVakecdnm------------slqymnqVPNQREYVYIPWsh-nSNIS 492 Candida albicans
731860     60 PLLVLPEKIYLYSEp-----tVKELLPFDVVINVaeean-----------------dlrmQVPAVEYHHYRWeh-dSQIA 116 baker's yeast
AAK38128  209 ITTLINNALYVGGFpdsqtvpQLHALGIRHIVNCcaqdvrt-------------apevaeSFHLHYFKSYDSee-yLILH 274 Leishmania major
9629014    27 QITRITEYVYLGSYnna-malESSGVPFRYVLNMsmvry----------------slpgsSATIVHIPIPDNd--qVHIA 87  Molluscum contagio...

Feature 1                            ##  #  ##                                                
1VHR_A     99 AYFERAADFIDQALAQkNGRVLVHCREGYSRSPTLVIAYLMmrq------kmDVKSALSIVRQNR--------EIGPNDG 164 human
CAC32252  363 EYLIKAFRFIERARSE-HSRVLVHCRRGISRSAAIIVAYLMase------hrSYENALKFVTERRs-------CVSLNLA 428 Leishmania major
1709121   296 KDLSRLTRIIHTAHSQ-GKKILVHCQCGVSRSASLIVAYIMryy------glSLNDAYNKLKGVAk-------DISPNMG 361 baker's yeast
T39517    134 LELDKLVSFVAYNAMQlNKKVLINCQMGISRSACLMIAFIMktl------nlNVSDAYEYVKERSp-------WIGPNMS 200 fission yeast
9631873    86 KYLGVSSMAIRDVTRY-KGNVLVHCRAGQNRSASVTAAYIMtik------giTAREAMDIVRSRKc-------ETFRPSN 151 Paramecium bursari...
P80994     87 IYFDDITAFLSKCDQR-NEPVLVHCAAGVNRSGAMILAYLMsknke-sspmlYFLYVYHSMRDLRg-------AFVENPS 157 Raccoonpox virus
1172738   493 KDLFQITNKIDKFFTN-GRKILIHCQCGVSRSACVVVAFYMkkf------qlGVNEAYELLKNGDqkyidacdRICPNMN 565 Candida albicans
731860    117 LDLPSLTSIIHAATTK-REKILIHCQCGLSRSATLIIAYIMkyh------nlSLRHSYDLLKSRAd-------KINPSIG 182 baker's yeast
AAK38128  275 RDYDAFAGLMSTILEN-GEKAFVHCVAGVNRSVVLCAAFLMerl------slNPVEAVRVFRANGr------mRILDNKG 341 Leishmania major
9629014    88 KYFDGVAAFLERCEKS-HTPVLVHCIAGVNRSGAMIMAYLLhtrnrqipaviYFLYVYHGIKDIRg-------AFLENAS 159 Molluscum contagio...

Feature 1              
1VHR_A    165 FLAQLCQLN 173 human
CAC32252  429 FQERLSEFV 437 Leishmania major
1709121   362 LIFQLMEWG 370 baker's yeast
T39517    201 LIFQLSEYQ 209 fission yeast
9631873   152 FTSSLKAYE 160 Paramecium bursaria Chlorella virus 1
P80994    158 FKRQIIEKY 166 Raccoonpox virus
1172738   566 LIFELMEFG 574 Candida albicans
731860    183 LIFQLMEWE 191 baker's yeast
AAK38128  342 FRHQLIDHY 350 Leishmania major
9629014   160 FKRQLVDHY 168 Molluscum contagiosum virus subtype 1

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