1ESC,1YZF,1IVN,1VJG,1WAB,1DEO,1ESE


Conserved Protein Domain Family
SGNH_hydrolase
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cd00229: SGNH_hydrolase 
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SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.
Links
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Statistics
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PSSM-Id: 238141
Aligned: 187 rows
Threshold Bit Score: 41.629
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1ESE; Streptomyces Scabies Esterase binds methylphosphonate, an analog of the second transition state
    - View structure with Cn3D
  • Citation:PMID 7773790
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:the histidine side chain may be oriented by a backbone oxygen or by an acidic sidechain
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                                                   #                     
1ESC          8 TVFFGDSYTAnfgiapvtnqdsergwcfqakenypavatrsladkgitldvqaDVSCGGAlihhfwekqelpfga----- 82  Streptomyces sca...
ZP_01107674  27 ILIIGDSISIgytpfvsenlk----------------------giadvyhnpgNAQHTGTglesiet------------- 71  Flavobacteriales...
AAO78267     46 VLLIGNSITRgyygkveaal-----------------------kekayvgrlsNSKSVGDpalieela------------ 90  Bacteroides thet...
XP_136686    18 VVVLGDSIQRavykdlvlllqkdcll------------sssqlkskgelsferDVLLEGGrwgrmhngahyrevrqfcsg 85  house mouse
1ESE          8 TVFFGDSYTAnfgiapvtnqdsergwcfqakenypavatrsladkgitldvqaDVSCGGAlihhfwekqelpfga----- 82  Streptomyces sca...
NP_969218    25 VLLLGDSHAYgrygsvldahfr-------------------kgdtqvtslsscGSSPSTWttssenfkstncgfwkknak 85  Bdellovibrio bac...
Q9WX69       49 LLIIGDSHVTfkdsllsvlpdef-----------------tkqgakvvtygvcSSTAADWvvpnpnngcgaaervgdapi 111 Gluconacetobacte...
AAL71846     11 MLVLGESHMSfpdsllnplqdnl-----------------tkqgavvhsigacGAGAADWvvpkkvecggertptgkavi 73  Pseudomonas fluo...
ZP_01280900 467 VAVFGDSVAWtlmrylpetpg----------------------lhfsnyttigCGIARGGpykttgqtltqkpece---- 520 Mycobacterium sp...
EAL28654    408 FPLLGDDFLLylarmelrcr------------------------fkrtervlqSGLCVSGqtisgarsr----------- 452 Drosophila pseud...

Feature 1                                               #                                       
1ESC         83 -----------------gelppqqdalkqdtQLTVGSLGGNTlgfnrilkqcsdelrkpsllpgdpvdgdepaakcgeff 145 Streptomyces sca...
ZP_01107674  72 ------------------------wvgdndwDAIQFNWGLWDlcyrhadskvqgn------------------------- 102 Flavobacteriales...
AAO78267     91 -----------------------vvlkntkfDVIHFNNGLHGfdy----------------------------------- 112 Bacteroides thet...
XP_136686    86 rhlirfyfltrayspyvedilqqlrwgeyapDLVIMNSCLWDlsr----------------------------------- 130 house mouse
1ESE         83 -----------------gelppqqdalkqdtQLTVGSLGGNTlgfnrilkqcsdelrkpsllpgdpvdgdepaakcgeff 145 Streptomyces sca...
NP_969218    86 gq--------etrvtshrlpsfgeelaatkpDLTVITLGTNFlaspgn-------------------------------- 125 Bdellovibrio bac...
Q9WX69      112 g---------apdmkpaspppitsliekwhpNVVMVILGDTMaaygqn-------------------------------- 150 Gluconacetobacte...
AAL71846     74 -----------ygknamsttpiqeliakdkpDVVVLIIGDTMgsytnp-------------------------------- 110 Pseudomonas fluo...
ZP_01280900 521 ----------------twptrwaqrighdrpDVVLLMIGRWElvdrin-------------------------------- 552 Mycobacterium sp...
EAL28654    453 ----------------------lhhllvnkgTQIIVNIGSVDimrg---------------------------------- 476 Drosophila pseud...

Feature 1                                                                                       
1ESC        146 gtgdgkqwlddqfeRVGAELEELLDrigy------fapdAKRVLVGYprlvpedttkcltaapgqtqlpfadipqdalpv 219 Streptomyces sca...
ZP_01107674 103 -rdkengkitftmdEYASNLDSIVTilkt-------tskAKLIFLTTsfvpeneag-----------------------r 151 Flavobacteriales...
AAO78267    113 -----------teeEYDKSFPKLIKiirk------yapkAKLIWANTtpvrtgegm-----------------------k 152 Bacteroides thet...
XP_136686   131 -----------yrsNFLRNYREDLErlfqrld-qvlpthCLMVWSTTmpvaevvsgg---------------------fi 177 house mouse
1ESE        146 gtgdgkqwlddqfeRVGAELEELLDrigy------fapdAKRVLVGYprlvpedttkcltaapgqtqlpfadipqdalpv 219 Streptomyces sca...
NP_969218   126 ---------iksekAHVEKMMKQINaa-----------gSACIWVGPpdl------------------------------ 155 Bdellovibrio bac...
Q9WX69      151 ---------avskdWVDEQVKTLTYai----------gkTACIWVGPtwg------------------------------ 181 Gluconacetobacte...
AAL71846    111 ---------vfpkaWAWKSVTSLTKait--------dtgTKCVWVGPpwg------------------------------ 143 Pseudomonas fluo...
ZP_01280900 553 --------egkwthVGDDAYDGYLRgeldraldilsstgARVVVTTApynrraeq------------------------a 600 Mycobacterium sp...
EAL28654    477 ----------rpivQIQHDFRQLVKdmh---------nrGLVPILTTlaplany-------------------------- 511 Drosophila pseud...

Feature 1                                                                             #  #      
1ESC        220 ldqiqkrLNDAMKKAAADgg----------aDFVDLyagtgantacdgadrgigglledsqlellgtkipWYAHPNDKGR 289 Streptomyces sca...
ZP_01107674 152 ykndairYNDAAKKIMQKhsi--------ivNDIYEqsipihq---------------------kygkglDDVHYSNLGY 202 Flavobacteriales...
AAO78267    153 efapiteRLNVRNQIALKhinr------asiEVNDLwkvvidh--------------------peyyaggDGTHPIDAGY 206 Bacteroides thet...
XP_136686   178 lrdapgcPSRLREDVMEAnfyssreaarrgfDVLDLhfhfrha---------------------gqhrlsDGVHWDERAH 236 house mouse
1ESE        220 ldqiqkrLNDAMKKAAADgg----------aDFVDLyagtgantacdgadrgigglledsqlellgtkipWYAHPNDKGR 289 Streptomyces sca...
NP_969218   156 ----kkdPFKKNLELGVKelkswa--danncQFIDStkltky-----------------------pggksDGIHYGPKDS 206 Bdellovibrio bac...
Q9WX69      182 ----qfsPRYGKTDQRATemasflkgevapcSYVDGtallkq----------------------gsvntiDGIHATPESY 235 Gluconacetobacte...
AAL71846    144 ----kvgSQYKKDDTRTKlmssflasnvapcTYIDSltfskp----------------------gewittDGQHFTIDGY 197 Pseudomonas fluo...
ZP_01280900 601 dgtlypeDDPDRADAWNEllreat-akrpnvTVLDLnkklsprgyyt-------------nrvegiqmrdDGVHPTKEAV 666 Mycobacterium sp...
EAL28654    512 chdkamcDKVVKFNQFIWkeca------sylKVIDIhsclvnengvvrfd------cfqyssrnvtgskeSYVFWNKIGR 579 Drosophila pseud...

Feature 1                 
1ESC        290 DIQAKQVADK 299 Streptomyces scabiei
ZP_01107674 203 EKLSELVTNF 212 Flavobacteriales bacterium HTCC2170
AAO78267    207 SALANQVIKV 216 Bacteroides thetaiotaomicron VPI-5482
XP_136686   237 RYLSQLLLAH 246 house mouse
1ESE        290 DIQAKQVADK 299 Streptomyces scabiei
NP_969218   207 AAWGEAVVKE 216 Bdellovibrio bacteriovorus HD100
Q9WX69      236 RVWGDAIVQA 245 Gluconacetobacter xylinus
AAL71846    198 QKWAKAIGTA 207 Pseudomonas fluorescens
ZP_01280900 667 EWLTPWLTEA 676 Mycobacterium sp. JLS
EAL28654    580 QRVLQMIEAS 589 Drosophila pseudoobscura

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