1YAZ,1AZV,1DO5,1EQW,1ESO,1F1G,1JK9,1L3N,1SRD,1SXA,1XSO,1YAI,2APS


Conserved Protein Domain Family
Cu-Zn_Superoxide_Dismutase
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cd00305: Cu-Zn_Superoxide_Dismutase 
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Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene causes familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Cytoplasmic and periplasmic SODs exist as dimers, whereas chloroplastic and extracellular enzymes exist as tetramers. Structure supports independent functional evolution in prokaryotes (P-class) and eukaryotes (E-class) [PMID:8176730].
Links
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Statistics
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PSSM-Id: 238186
Aligned: 67 rows
Threshold Bit Score: 110.428
Created: 6-Mar-2002
Updated: 10-Aug-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                    # #              
1YAZ_A      1 VQAVAVLKGda-------gvSGVVKFEQAses-epTTVSYEIAGNSPn----------AERGFHIHEFGDat-----ngC 57  baker's yeast
P20379     25 TSATAVVKAgdg------kdAGAVTVTEAph---gVLLKLELKGLTP-----------GWHAAHFHEKGDcgt----pdF 80  Caulobacter vibrio...
O67149     15 FSIAQELKThadivnqkgekIGKAELIQTns---gVLIKLEASNLPPn----------AELAFHIHELGKcdp----pdF 77  Aquifex aeolicus
NP_347991  30 RRAVATIVGgpla----pniRGTVTFTSVpn---gTEVSVVLNGLPPyrpamggrpqvGPHGFHIHQNGNctpgtaaqpF 102 Clostridium acetob...
NP_640566   9 TTATAELKPtkg-----ndvKGTVTFKTVdg---aLRVTGQLSGLKPn----------TEHGFHIHEKGDcsa----pdG 66  Xanthomonas axonop...
P96278     70 QSLTSTLTApdg------tkVATAKFEFAngyatvTIATTGVGKLTP-----------GFHGLHIHQVGKcepn-svapT 131 Mycobacterium bovis
Q9AGW2     56 PSITTHLKApdg------tqVATAKFEFSng---yATVTIETTANGVlt--------pGFHGVHIHKVGKceps-svapT 117 Mycobacterium aviu...
Q9CBI6     70 PNIITRLNApdg------tqVATAKFEFNng---fATITIATTGVGHla--------pGFHGVHIHKVGKc-------eP 125 Mycobacterium leprae
NP_694002  46 EEVLVSLENneg------qvVGTATLTEGee---gVQISLEGENLPA-----------GEHGFHIHEAGKcel----pnF 101 Oceanobacillus ihe...
XP_308380  16 VGATLVADNpeq------qiMGTISFRQWap--ghVQTAINVTGLPV-----------GKHAVHVHAFGDmr-----egC 71  Anopheles gambiae ...

Feature 1          #                        #  #                                              
1YAZ_A     58 VSAGPHFNPFKKt------HGaptd--evrHVGDMGNV--KTDe-------nGVAKGSFKDSLIKLIgp-------tSVV 113 baker's yeast
P20379     81 KSAGAHVHTAATt-----vHGllnp--danDSGDLPNIfaAAD---------GAATAEIYSPLVSLKga-------gGRP 137 Caulobacter vibrio...
O67149     78 KSAKGHFNPFKKk------HGllnp--egpHAGDMPNI--HTDd-------kGNVRVQVLNPFVTLKk--------gKKN 132 Aquifex aeolicus
NP_347991 103 PGTGEHWNPTNQp------HGn--------HAGDFPVV--FSNn--------GYARMTFFTNKFRVP----------QVI 148 Clostridium acetob...
NP_640566  67 SSAGGHFNPSQSd------HGnisa--dphHGGDMPNI--TADaq-----gnASIDGPVSSNVNLGKad------qfDIA 125 Xanthomonas axonop...
P96278    132 GGAPGNFLSAGGhyh-vpgHTgt------pASGDLASL--QVRgdgs-amlvTTTDAFTMDDLLSGAktaiiihagaDNF 201 Mycobacterium bovis
Q9AGW2    118 GGAPGDFLSAGGhfq-apgHTge------pASGDLTSL--QVRkdgs-gtlvTTTDAFTMEDLLGGRktaiiihagaNNF 187 Mycobacterium aviu...
Q9CBI6    126 SSAGPTGGAPGDfls-aggHFqvpghtvepASGNLTSL--QVRkdgigtlvtTTDAFTMNDLLAGQKtaiii-hagaDNF 201 Mycobacterium leprae
NP_694002 102 ESAGSHYNPTNAk------HGfnhp--egpHAGDLENI--TVEe-------dGTVQTEVDAPMVTLQa--------dTEN 156 Oceanobacillus ihe...
XP_308380  72 KSTGPHFRSSIIgnievkeDGn--------AMIDFHSP--YINl-------fGFAGIVGRSIVIHEKp---------SEV 125 Anopheles gambiae ...

Feature 1           #                          
1YAZ_A    114 GRSVVIHAGQDDLGKGDTEESLKTGNAGPRPAC 146 baker's yeast
P20379    138 ALLDADGSSIVVHANPDDHKTQPIGGAGARVAC 170 Caulobacter vibrioides
O67149    133 SLFKEGGTALVIHGGPDDYKSDPAGNAGKRIAC 165 Aquifex aeolicus
NP_347991 149 GKSVVLHESPDDYRTQPAGASGRKVACGVIRAV 181 Clostridium acetobutylicum
NP_640566 126 GHAVIVHADADDYKTQPTGNAGGRLACGVITTD 158 Xanthomonas axonopodis pv. citri str. 306
P96278    202 ANIPPERYVQVNGTPGPDETTLTTGDAGKRVAC 234 Mycobacterium bovis
Q9AGW2    188 ANIPAERYNQTNGTPGPDEMTMSTGDAGKRVAC 220 Mycobacterium avium subsp. paratuberculosis
Q9CBI6    202 GNIPPERYSQVNGTPGPDATTISTGDAGKRVAC 234 Mycobacterium leprae
NP_694002 157 TLYTEQGTSLIIHSGPDDYKSQPSGDAGDRIAC 189 Oceanobacillus iheyensis HTE831
XP_308380 126 YRFPDLSINNPISFQGEEDTVGARIACGLITIL 158 Anopheles gambiae str. PEST

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