Conserved Protein Domain Family
SIRT7

?
cd01410: SIRT7 
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Statistics
?
PSSM-Id: 238701
Aligned: 14 rows
Threshold Bit Score: 298.061
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Comment:by similarity to Archaeoglobus fulgidus Sir2 homolog, Sir2_Af2, structure 1MA3

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
Q9NRC8      100 KYLVVYTGAGISTAASIPDYRGPnGVWtllq--------------kgrSVSAADLse--------aePTLTHMSITRLHe 157 human
NP_651664   124 KHLVCYTGAGISTAALIPDYRGSqGIWtllq--------------kgqDIGEHDLss--------anPTYTHMALYELHr 181 fruit fly
CAG06028     27 NHLVVYTGAGISTAASIPDYRGPnGVWtqlq--------------kgqTVCSSDLsk--------aePTLTHMCIRMLQk 84  Tetraodon nigrov...
EAA33563     35 KHFVVFTGAGVSTSAGIPDFRGPeGVWtlma--------------qgrQATKKSVdvl------qaiPTKTHMALVELQe 94  Neurospora crassa
AAD42226     45 KHLVVFTGASISTSSGIPDFRGPkGVWtlqrs------------gkgvPGATLPFqr--------avPTLTHMALVELEk 104 Indian rice
CAG33481     45 SSVVFHTGAGISTASGIPDFRGPhGVWtmee-------------rglaPKFDTTFes--------arPTQTHMALVQLEr 103 human
NP_200387    45 KHLVVFTGAGISTSCGIPDFRGPkGIWtlqre------------gkdlPKASLPFhr--------amPSMTHMALVELEr 104 thale cress
Q89LY4       23 KTIVPFTGAGISTECGIPDFRSPgGIWtrnrpipfd----gfvasqeaRDESWRRrfameetfaaarPGRGHRALASLYr 98  Bradyrhizobium j...
Q8CJM9        5 PLVAILSGAGVSTDSGIPDYRGPnGLWrrdpeaeklvtyeyymgdpeiRRRSWLMrrdsa--alhaePNAAHRAVADLEr 82  Streptomyces coe...
ZP_00057915 198 ERTTVLTGAGISTASGIPDFRGPqGLWtrnpgaaamfdidiyrsdvnvRREVWRMrrdsp--altaePNDAHRALVDLDr 275 Thermobifida fusca
Feature 1                  #                 #                                                  
Q9NRC8      158 qklvqhVVSQNCDGLHLRSGLprtaISELHGNMYIEVCtsCvpnreyvrvfdvt-ertalhrhqtgrtCh--------kC 228 human
NP_651664   182 rrllhhVVSQNCDGLHLRSGLprnsLSEIHGNMYVEVCknCrpnsvywrqfdtt-emtarychkthrlCh--------rC 252 fruit fly
CAG06028     85 eklvkyVVSQNCDGLHLRSGLprqaLSELHGNMFIEVCtsCspvreyvrlfdvt-ertslhrhgtgrrCg--------tC 155 Tetraodon nigrov...
EAA33563     95 rgilkgLISQNCDGLHRRSGIradmISELHGNTNIEHCknCgkeflradfyavapdnrplhdhrtgrkCp--------iC 166 Neurospora crassa
AAD42226    105 tgrlkfVISQNVDSLHLRSGLprekLAELHGNSFKEICpsCkkeylrdfeie------tiglkdtprrCsd------knC 172 Indian rice
CAG33481    104 vgllrfLVSQNVDGLHVRSGFprdkLAELHGNMFVEECakCktqyvrdtvvg------tmglkatgrlCtvakarglraC 177 human
NP_200387   105 agilkfVISQNVDGLHLRSGIprekLSELHGDSFMEMCpsCgaeylrdfeve------tiglketsrkCsv------ekC 172 thale cress
Q89LY4       99 agkvpaVITQNIDNLHQASGFahehVIELHGNTTYARCvgCgqtyqldwvk-------rrfdqdgapnCt--------vC 163 Bradyrhizobium j...
Q8CJM9       83 rgvpvrVLTQNVDGLHQLAGVsarkVLELHGTARDCVCtgCgargpmadvla------rieageddppCl--------dC 148 Streptomyces coe...
ZP_00057915 276 tgrllaVITQNIDGLHQKAGLaperVLEVHGTIHEVEClsCgrrvptpdvl-------arldeesdprCl--------aC 340 Thermobifida fusca
Feature 1                # #####                             ###                                
Q9NRC8      229 gtq-lrDTIVHFGERGTlgqplnwEAATEAASr-aDTILCLGSSLKVLkkyPRLWCMTkpp-------------srrPKL 293 human
NP_651664   253 sep-lyDTIVHFGERGNvkwplnwAGATANAQr-aDVILCLGSSLKVLkkyTWLWQMDrpa-------------rqrAKI 317 fruit fly
CAG06028    156 gge-lrDTIVHFGERGTleqplnwQGAAEAARm-aDVILCLGSSLKVLkkyACLWSMNrpa-------------nkrPKL 220 Tetraodon nigrov...
EAA33563    167 ltqplhDTIIHFSEDLPlg---pwSRAEAHCEk-aDLCLVLGSSLTVT---PANELPQlvgeraaaqrkkqqtqqpdTDL 239 Neurospora crassa
AAD42226    173 gar-lkDTVLDWEDALPpe----eMDAAKEQCqtaDLVLCLGTSLQIT---PACNMPLlsl-------------kngGRV 231 Indian rice
CAG33481    178 rge-lrDTILDWEDSLPdr----dLALADEASrnaDLSITLGTSLQIR---PSGNLPLatk-------------rrgGRL 236 human
NP_200387   173 gak-lkDTVLDWEDALPpk----eIDPAEKHCkkaDLVLCLGTSLQIT---PACNLPLkcl-------------kggGKI 231 thale cress
Q89LY4      164 dep-vkTATISFGQMMPee---emQRATALSRa-cDLFIAIGSSLVVW---PAAGFPMmak-------------ragARL 222 Bradyrhizobium j...
Q8CJM9      149 ggv-lkTATVMFGERLDpv---vlGEAAAISKa-cQVFVAVGTSLQVE---PAAGLARvav-------------ehgARL 207 Streptomyces coe...
ZP_00057915 341 ggi-qkAATISFGQRLDpd---vlDAAITAAKd-cDLFLTVGTSLTVH---PVAGLCDiar-------------ehgARL 399 Thermobifida fusca
Feature 1                               
Q9NRC8      294 YIVNLQWTpkd---dwaALKLHGK 314 human
NP_651664   318 CVVNLQWTpkd---aiaSIKINGK 338 fruit fly
CAG06028    221 YIVNLQWTpkd---dlaVLKIHGR 241 Tetraodon nigroviridis
EAA33563    240 VICNLQDTdldylcpspDHRIYAR 263 Neurospora crassa
AAD42226    232 AIVNLQATpkd---kkaSLVIHGL 252 Indian rice
CAG33481    237 VIVNLQPTkhd---rhaDLRIHGY 257 human
NP_200387   232 VIVNLQKTpkd---kkaNVVIHGL 252 thale cress
Q89LY4      223 VIINREPTeqd---diaDLVIRHD 243 Bradyrhizobium japonicum
Q8CJM9      208 VVVNAEPTpyd---elaDEVIREP 228 Streptomyces coelicolor
ZP_00057915 400 VIINAEPTpyd---evaDAVLRDP 420 Thermobifida fusca

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap