1WQJ,1IGL


Conserved Protein Domain Family
IlGF
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cd04368: IlGF 
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IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a cellular level they affect cell cycle, apoptosis, cell migration, proliferation, and differentiation. Typically, the active forms of these peptide hormones are single chains cross-linked by three disulfide bonds.
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Statistics
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PSSM-Id: 239834
Aligned: 20 rows
Threshold Bit Score: 99.3754
Created: 31-Aug-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:IGFBP binding surface
Evidence:
  • Comment:Insulin-like Growth Factor Binding Proteins control extracellular distribution and activity of IlGFs
  • Structure:1WQJ: Human IlGF1 binds to the N-terminal domain of IGFBP4
    - View structure with Cn3D
  • Comment:receptor-binding interaction for IlGF2 obtained from modelling studies
  • Citation:PMID 9822601
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #        #       #####                                               
1WQJ_I         1 GPETLCGAELVDALqFVCGDRGFYFNKPTgygs---ssrrAPQTGIVDECCFRSCDLRRLEMYCAPLKPAK 68  human
P22618        39 LSETLCGSELVDTLqFVCDDRGFFFVPQHvpprrgahrrsRARKGIVEECCFKGCSLRLLEMYCARPSKAE 109 Atlantic hagfish
CAA90412      25 SPETLCGAELVDALqFVCGDRGFYFNKPAgyrs----svrRPHRGIVNECCFQSCDLKLLEMYCAKPQRAD 91  spiny dogfish
CAA90413      53 LEETLCGSELVDTLqFICAERGFYFVSKVvgr------rsRQNRGIVEECCFRSCDLLILETYCAVPPEAA 117 spiny dogfish
BAC15764      54 ASETLCGSELVDALqFVCGDRGFYFVRHPssr-----shgRPKKGIVEECCFSKCDLRLLEMYCAKPAKSE 119 sea lamprey
CAG04155      45 GPETLCGAELVDTLqFVCGERGFYFSKPTgyg-----tnsRRSSGIVEECCFQSCDLWHLEMYCAPAKTNK 110 Tetraodon nigroviridis
NP_001004384  49 GPETLCGAELVDALqFVCGDRGFYFSKPTgygs---ssrrLHHKGIVDECCFQSCDLRRLEMYCAPIKPPK 116 chicken
XP_690074     43 GARARCGRELVDDLeFVCGDRGFYIGKPGaars---ggprSRGKGIVDQCCVRGCDLQHLELYCAKSKKVR 110 zebrafish
AAI14263      45 GPETLCGAELVDTLqFVCGDRGFYFSKPTgygp---ssrrSHNRGIVDECCFQSCELRRLEMYCAPVKTGK 112 zebrafish
P16501        49 GPETLCGAELVDTLqFVCGDRGFYFSKPTgygs---nnrrSHHRGIVDECCFQSCDFRRLEMYCAPAKQAK 116 African clawed frog

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