Conserved Protein Domain Family
RRM_RBM20
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cd12685: RRM_RBM20 (this model, PSSM-Id:241129 is obsolete and has been replaced by 410086)
RNA recognition motif of vertebrate RNA-binding protein 20 (RBM20)
This subfamily corresponds to the RRM of RBM20, an alternative splicing regulator associated with dilated cardiomyopathy (DCM). It contains only one copy of RNA-recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Links
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Statistics
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PSSM-Id: 241129
Aligned: 4 rows
Threshold Bit Score: 152.492
Created: 27-Sep-2011
Updated: 1-Feb-2013
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to Homo sapiens polypyrimidine tract binding protein.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            # ##                        # #  ### #                              #####
Q5T481        518 RVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYtEAAQAMVQYYQekSAVINGEKLLIRMSKR 593  human
XP_002942947  379 RVVHICNIPEGSCNENDVVNLGLPFGKVTNYILMKSTNQAFLEMAYtEAAEAMVQFYQekPAMINDEKLLIRMSKR 454  western clawed frog
CAG01297      278 SMAYAAAAAQGSCTENDVINLGLPFGKVTNYILMRSTHQAFLEMAYvEAAQAMVQYYQltPAMINNQKLLIRMSKR 353  spotted green puf...
XP_421755     498 RVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYsEAAQAMVQYYKekPAMINDDKLLIRMSKR 573  chicken

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