Conserved Protein Domain Family
Mannosyl_trans
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pfam05007: Mannosyl_trans 
Mannosyltransferase (PIG-M)
PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilize nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates.
Links
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Statistics
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PSSM-Id: 252941
Aligned: 6 rows
Threshold Bit Score: 313.579
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9W2E4 177 ISTRGSGDCFSSFFVILTIYLLLKSEhnvtrsywlIFGAGLAHG-LVIHLRLYPLLFSLAYYLSL-STRLTQ-------- 246 fruit fly
Q9EQY6 140 VSSRGNADSIVASLVLTTLYLIEKRL---------IACAAVFYG-FAVHMKMYPVTYILPIALHL-RPERDSdeglrlar 208 Norway rat
P47088 127 ISTRGNAESVLCCLIMFTLFFLQKSR---------YTLAGILYG-LSIHFKIYPIIYCIPIAIFIyYNKRNQ-------- 188 Saccharomyces cerevis...
Q9P6R5 112 ISTRGNCEAILGILSIALLYLIEKKSvw---------lASLILG-FSVHFKIYPFMYGIAFLVYF-SKPKKGs------- 173 Schizosaccharomyces p...
Q9BPQ5 134 VSTRGNSDMLVTFMSLMVLSKFARRK---------CYQAAAVLG-FAVHFKIYPIIYALPLTL----GVWEQ-------- 191 Trypanosoma brucei br...
Q17515 146 ISARGNAESIVAAVVLLNIVLLQKGY---------WKSAALVHGaLAIQLKIYPLIYLPSVFLSL-STIGEQs------- 208 Caenorhabditis elegans

Q9W2E4 247 -TPLDFLC----QILRPnkQQLCLI--SGTLISLVAFTWTFYTMYGWEYIYEAYLYHFVRKDPRHNFSLQFLLQYLGSAS 319 fruit fly
Q9EQY6 209 ySFQARLYdflkRLCSW--AVLLFV--AIAGLTFLALSFGFYYKYGWEFLEHTYLYHLTRRDIRHNFSPYFYMLYLTAES 284 Norway rat
P47088 189 -GPRTQLT----SLLNI-------G--LSTLTTLLGCGWAMYKIYGYEFLDQAYLYHLYRTDHRHNFSVWNMLLYLDSAN 254 Saccharomyces cerevis...
Q9P6R5 174 -TFMEKFL----SLLSI--NQLKIV--VGSLFMFTICNLLMYYLYGSPFLEHTYLYHFGRTDHRHNFSLHHLNLY-YESS 243 Schizosaccharomyces p...
Q9BPQ5 192 -SVAASTNtw-rRVVKT--AVVVSIcaLMAAISFAVPTVLCYMKYGQQYLNEAFIYHVYREDHRHNFSPYWLLMYLNMAR 267 Trypanosoma brucei br...
Q17515 209 -CVVNKFK----SLVSNw-KGFAYM--LVTLTSFAAVVLFFFQIYGQLFLDEYLIYHVKRRDLAHNFSPYFYLLYLYEAN 280 Caenorhabditis elegans

Q9W2E4 320 SvaePSAIL----KTLVLAPQFLLILYL-SLSFgq-fRQTLPFCIFAVAFVIVTYNSVVTSQYFIWYLAILPLCLNN--- 390 fruit fly
Q9EQY6 285 K---WSFTL----GIAAFLPQFILLSAA-SFAY----YRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPL--- 349 Norway rat
P47088 255 Ke-nGESNL----SRYAFVPQLLLVLVTgCLEWwnptFDNLLRVLFVQTFAFVTYNKVCTSQYFVWYLIFLPFYLSR--- 326 Saccharomyces cerevis...
Q9P6R5 244 FgakASS-------LFAFLPQLSLCMLI-PLVFg---KKNLPGTLFAQTFAFVTFNKVCTSQYFMWYLVFLPLVLPN--- 309 Schizosaccharomyces p...
Q9BPQ5 268 Rh--lGQGVdfspRLVAFAPQAVVLSFV-SYKL----RRNTAHACCVQTVLFVAFNKVCTVQYFVWFIPFLAFLFCEpke 340 Trypanosoma brucei br...
Q17515 281 Pt--mSQII----GLGAFIPQIVLIVFF-AFKH----YDDLPFCWFITTFAFVTYNKVCTSQYFVWYIVLLPLLAHK--- 346 Caenorhabditis elegans

Q9W2E4 391 -----------FKMlSWRRCFGLLFLWLLAQALWLLPAYLLEFHTWNTFYW-IGLQGAVFFATNGYILEQLL 450 fruit fly
Q9EQY6 350 -----------VRM-PWKRAVVLLMLWFIGQALWLAPAYVLEFQGKNTFLF-IWLAGLFFLLINCSILIQII 408 Norway rat
P47088 327 -----------THI-GWKKGLLMATLWVGTQGIWLSQGYYLEFEGKNVFYPgLFIASVLFFVTNVWLLGQFI 386 Saccharomyces cerevisiae S288C
Q9P6R5 310 -----------SKLlS-KKGLICLSLWIIGQLLWLISAYNLEMLGKSVFIP-LWLSGLLFFFFNVYELKIIL 368 Schizosaccharomyces pombe 972h-
Q9BPQ5 341 veddesggsgaFKFfSWVKALGVVLMWAATIPLWVTTAVPLEFHGYSDFAQ-LWIVSCLFFLA-MVVLASML 410 Trypanosoma brucei brucei TRE...
Q17515 347 -----------IMM-SRQLALSLMAAWFATQGIWLLAAYLFEFQGWNTFFL-MFLASCLFLIANSFILKQII 405 Caenorhabditis elegans
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