2J5W,1KCW,1KCW,2R7E,2R7E,3CDZ,1SDD,1SDD


Conserved Protein Domain Family
CuRO_1_ceruloplasmin_like
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cd04199: CuRO_1_ceruloplasmin_like 
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Cupredoxin domains 1, 3, and 5 of ceruloplasmin and similar proteins
This family includes the first, third, and fifth cupredoxin domains of ceruloplasmin and similar proteins including the first, third and fifth cupredoxin domains of unprocessed coagulation factors V and VIII. Ceruloplasmin (ferroxidase) is a multicopper oxidase essential for normal iron homeostasis. It functions in copper transport, amine oxidation and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains and exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. Human Factor VIII facilitates blood clotting by acting as a cofactor for factor IXa. Factor VIII and IXa forms a complex in the presence of Ca+2 and phospholipids that converts factor X to the activated form Xa.
Links
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Statistics
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PSSM-Id: 259862
Aligned: 10 rows
Threshold Bit Score: 259.26
Created: 13-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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trinuclear Cu
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: trinuclear Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the trinuclear copper binding site of other multicopper oxidases with structure of bound coppers
  • Comment:Trinuclear copper site ligands are typically one or two HxH motifs that can be in the same domain/subunit or in different domains/subunits.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
2J5W_A     372 RHYYIAAEEIIWNYapsgidiftkenltapgsdsavffeqgttriggSYKKLVYREYTDasftnrkergpeeehLGILGP 451  human
1KCW_A     713 RTYYIAAVEVEWDYspqrewekelhhlqeq-nvsnafldkgefyigsKYKKVVYRQYTDstfrvpverkaeeehLGILGP 791  human
1KCW_A       3 KHYYIGIIETTWDYasdhgekklisvdte---hsniylqngpdrigrLYKKALYLQYTDetfrtt---iekpvwLGFLGP 76   human
2R7E_A     383 WVHYIAAEEEDWDYaplvlapddrsyk-------sqylnngpqrigrKYKKVRFMAYTDetfktr---eaiqheSGILGP 452  human
2R7E_A       4 RRYYLGAVELSWDYmqsdlgelpvdarf-----pprvpksfpfntsvVYKKTLFVEFTDhlfnia---kprppwMGLLGP 75   human
3CDZ_B      48 RHYFIAAVERLWDYgmsssphvlr--------------nraqsgsvpQFKKVVFQEFTDgsftqplyrgelnehLGLLGP 113  human
1SDD_A       4 RQFYVAAQSIRWNYrpesthl-------------------sskpfetSFKKIVYREYEAyfqkek----pqsrtSGLLGP 60   cow
NP_841583   36 REYWIAAEKTDWNYaptganqidla------------sdlgvwgktlTYTKYRYIGYTDgsyshp---lpqpewMGILGP 100  Nitrosomonas eur...
1SDD_B       7 KYYYIAAEEISWDYskfvqsdd-----------------vdyvpedtVYKKVVFRKYLDstftkldpqgeyeehLGILGP 69   cow
P12259     350 WEYFIAAEEVIWDYapvipanmdkkyr-------sqhldnfsnqigkHYKKVMYTQYEDesftkht-vnpnmkeDGILGP 421  human

Feature 1                              # #                                                     
2J5W_A     452 VIWAEVGDTIRVTFHNKGaYPLSIEPIGVRfnknnegtyyspnynpqsrsvppsashVAPTETFTYEWTVPKEvgptnad 531  human
1KCW_A     792 QLHADVGDKVKIIFKNMAtRPYSIHAHGVQtess-------------------tvtpTLPGETLTYVWKIPERsgagted 852  human
1KCW_A      77 IIKAETGDKVYVHLKNLAsRPYTFHSHGITyykehegaiypd----nttdfqraddkVYPGEQYTYMLLATEEqspgegd 152  human
2R7E_A     453 LLYGEVGDTLLIIFKNQAsRPYNIYPHGITdvrplysrrlp------kgvkhlkdfpILPGEIFKYKWTVTVEdgptksd 526  human
2R7E_A      76 TIQAEVYDTVVITLKNMAsHPVSLHAVGVSywkasegaeydd----qtsqrekeddkVFPGGSHTYVWQVLKEngpmasd 151  human
3CDZ_B     114 YIRAEVEDNIMVTFRNQAsRPYSFYSSLISyeedqrqg------------aeprknfVKPNETKTYFWKVQHHmaptkde 181  human
1SDD_A      61 TLYAEVGDIMKVHFKNKAhKPLSIHAQGIKyskfsegasysd----htlpmekmddaVAPGQEYTYEWIISEHsgpthdd 136  cow
NP_841583  101 TIRAAVGDTIKIHFLNKTdMPLSMHPHGVMydkdnega------------dggkggsIPPGERYTYTWIVDQDagpgpgd 168  Nitrosomonas eur...
1SDD_B      70 VIRAEVDDVIQVRFKNLAsRPYSLHAHGLSyekssegktyed----dspewfkednaIQPNKTYTYVWHATTRsgpenpg 145  cow
P12259     422 IIRAQVRDTLKIVFKNMAsRPYSIYPHGVTfspyedevnssf----tsgrnntmiraVQPGETYTYKWNILEFdeptend 497  human

Feature 1              # #                    
2J5W_A     532 PVCLAKMYYSAVDptKDIFTGLIGPMKICKK 562  human
1KCW_A     853 SACIPWAYYSTVDqvKDLYSGLIGPLIVCRR 883  human
1KCW_A     153 GNCVTRIYHSHIDapKDIASGLIGPLIICKK 183  human
2R7E_A     527 PRCLTRYYSSFVNmeRDLASGLIGPLLICYK 557  human
2R7E_A     152 PLCLTYSYLSHVDlvKDLNSGLIGALLVCRE 182  human
3CDZ_B     182 FDCKAWAYFSDVDleKDVHSGLIGPLLVCHT 212  human
1SDD_A     137 PPCLTHIYYSYVNlvEDFNSGLIGPLLICKK 167  cow
NP_841583  169 PSSIVWLYHSHVMaeEEVNLGLIGTLIITAA 199  Nitrosomonas europaea ATCC 19718
1SDD_B     146 SACRAWAYYSAVNpeKDIHSGLIGPLLICRK 176  cow
P12259     498 AQCLTRPYYSDVDimRDIASGLIGLLLICKS 528  human

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