Conserved Protein Domain Family
PIKKc_ATM

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cd05171: PIKKc_ATM 
Catalytic domain of Ataxia Telangiectasia Mutated
ATM is critical in the response to DNA double strand breaks (DSBs) caused by radiation. It is activated at the site of a DSB and phosphorylates key substrates that trigger pathways that regulate DNA repair and cell cycle checkpoints at the G1/S, S phase, and G2/M transition. Patients with the human genetic disorder Ataxia telangiectasia (A-T), caused by truncating mutations in ATM, show genome instability, increased cancer risk, immunodeficiency, compromised mobility, and neurodegeneration. A-T displays clinical heterogeneity, which is correlated to the degree of retained ATM activity. ATM contains a FAT (FRAP, ATM and TRRAP) domain, a catalytic domain, and a FATC domain at the C-terminus. It is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The ATM catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Statistics
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PSSM-Id: 270715
Aligned: 54 rows
Threshold Bit Score: 391.517
Created: 19-Mar-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ## # #               # #  #                                         
AAF20175     1210 IVSFKPEFRLAGGL-NLPKIIDCVGSDGkeRRQLVKGQDDl-RQDAVMQQVFQMCNTLLQrnse------trkrKLTIRR 1281 African clawe...
XP_001324760 2302 IAQFEDKMKPLEGI-TKPVKIKVLGANGrkYHQILKGRNDdlRQDAVMQQLFQLSSQILEkn----------kpDLKIRS 2370 Trichomonas v...
EEE31760     1512 GDRLRMRVTVIGSGiTKPKLLCIWDRKGrkHKQCCKGREDv-RQDRVAQQLFSMLNQVFLeaps------tlekNFYLRT 1584 Toxoplasma go...
CCH46977     2430 IVNISPILQISSSGiSLPKIMRLQLSDGskHKMLLKGSTDdlRQDAIMEQVFEKVNTILKndke------trkrSLKMRT 2503 Wickerhamomyc...
P38110       2430 IVSVNETVGITTTGlSLPKIVTFNISDGttQKALMKGSNDdlRQDAIMEQVFQQVNKVLQndkv------lrnlDLGIRT 2503 Saccharomyces...
CCH60552     2509 ITSIKSTLIVSATGlSLPKIVSFTQSDGlqYKVLMKGSKDdlKQDSVMEQAFQKVNHIFAshkk------lrakYLKIRT 2582 Tetrapisispor...
EMH72366     2067 IAGISNVYSLVGGI-RAPKKMEFLGSDNkkYSFLLKSEDDl-RQDAVMQQLFDLCNRLFKqhq--------qtkQLRIRT 2136 Entamoeba his...
CBK22652       12 IGNFGSSFSVMATGiTAPRKMSCFSVQGdeYIQVIKRDEI--RSDCVVQQLFDLLNQLLRevqndpklvskkvdQILLRT 89   Blastocystis ...
EKX38308        2 VSRFENHYIIPGGI-TEPKKIVCISCNNvaFPQLVKKDDP--NTDLIASQLFSVVNVLLKkdsa------crerNLKMLM 72   Guillardia th...
ELP92073     2090 VSGFSKTYKVLGGV-NAPKKADFIGSDGecYTFIAKSKDEm-KQDAMIQQIFKVCNYAFLrnr--------ktrNMRLRT 2159 Entamoeba inv...
Feature 1         #           ####    #                                                           
AAF20175     1282 YKVVPLSHRSGVLEWCTGTVPIGEYLVNdkd-----------------gaHKRYRPGDYgslqcqrkmme---------- 1334 African clawe...
XP_001324760 2371 YKVVPLNPSAGIIEYVEKSISLGSYLTApn------------------gaHFRYKSNLSydkvyalfqnassnyhka--- 2429 Trichomonas v...
EEE31760     1585 YVVVPFSPAVGILEWVNDAVTLAQYLIGnpdng-------------yhgaHARYRPQDWtftacrqklrlarekalaqrr 1651 Toxoplasma go...
CCH46977     2504 YKVVPLGPQAGMIEFVANSIALSDILRPlhskd------------sisfsEAREMMRNCqssgt---------------- 2555 Wickerhamomyc...
P38110       2504 YKVVPLGPKAGIIEFVANSTSLHQILSKl---------------------HTNDKITFDqarkgmkav------------ 2550 Saccharomyces...
CCH60552     2583 YEVIPLDPGTGMIEFVRNSISLHEILNDlhkgd------------eltfnKARSLMKNAqnktp---------------- 2634 Tetrapisispor...
EMH72366     2137 YKVVPLTKESGMLEFVTGTEPLFNELSKihdlihpeeptfsstmsaldkaHKNFRNNNCldn------------------ 2198 Entamoeba his...
CBK22652       90 YKVVSITSDIGVLEYVRHSLTIRDYLVDdslclmlfli--rrqstkkrsaHRRYHPGEIengtilkkfek---------- 157  Blastocystis ...
EKX38308       73 YKVIPIAKDVGLIEFVEGAQSLSDVLVRkdt----------------dslHARFDPQDFnfvtcrqmisgiqksykiklg 136  Guillardia th...
ELP92073     2160 YKVIPLSKESGFLEFVKTAQPLFSIFVAn---------------------HKTIYPKETtaetiqreyceve-------- 2210 Entamoeba inv...
Feature 1                                                                                         
AAF20175     1335 ---------------------------vqrgrfeekyQMFLNVCENFRPVFRYFCMEKFl-dPAMWFEKRLAYTRSVATS 1386 African clawe...
XP_001324760 2430 -------------------nfnrsmeisneqkremliNTYIQICKDFKPCMRFFFIEKFs-nTGDWFKARMNYCRQTATN 2489 Trichomonas v...
EEE31760     1652 qmlslgtaddgglqkgqqkkeasgadagshslveslvQTYDEICDHFKPVLHHFFLEHFp-sADVWYEKRQRYRRTLAVS 1730 Toxoplasma go...
CCH46977     2556 ---------------------------------rerlNVYLKICKETQPIFRQFFIDTFt-nIDEWYESRQIYTKGISTN 2601 Wickerhamomyc...
P38110       2551 ----------------------------qtksneerlKAYLKITNEIKPQLRNFFFDSFp-dPLDWFEAKKTYTKGVAAS 2601 Saccharomyces...
CCH60552     2635 ---------------------------------sekvACFKELTDRIKPQLRKFFFNAFl-hPDDWFSAKMNYTKGVAVT 2680 Tetrapisispor...
EMH72366     2199 -----------------------------------yfDVFNKCVKSYTPSFHNLFDQLYgkdPKHLYDMKLNYINSTAVS 2243 Entamoeba his...
CBK22652      158 ---------------------------igkqdkqqrlELYQSITKQFTPVFHYFFLERFv-hPELWYHNIQNFISTLSIN 209  Blastocystis ...
EKX38308      137 -----------------kaktegermqlhsdmtrelrSKFDLICDKVSPVFRYHFLEISs-sASDYLGKRLNYTRSAAAS 198  Guillardia th...
ELP92073     2211 -------------------------tkkadrnvklkyQKFDECLKKYSPIFKILFEKWYghdARLLYEMRSAYLESLATS 2265 Entamoeba inv...
Feature 1                        # #          ##                                                  
AAF20175     1387 SIVGYIVGLGDRHVQNILIDeeSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVM 1465 African clawe...
XP_001324760 2490 SMVGYVFGIGDRHMNNILIDhlTGDVIHIDLGIAFEQGKM-LRVREIVPFRMTPDIIDGFGHCGGSGVFRNSCEETLSLL 2568 Trichomonas v...
EEE31760     1731 SMVSYIIGLGDRHTNNILLDvaSGDLIHIDFGVVFEQGKL-LAIPELVPFRLTRDLVDGLGCLGVAGCFKRDCETTMEVL 1809 Toxoplasma go...
CCH46977     2602 SIVGYMLGLGDRHLNNILIDkeTGEPIHIDLGVAFDQGKL-LPVPELVPFRLTRDIVDGLGITGVEGSFKKSSEHVFRVL 2680 Wickerhamomyc...
P38110       2602 SIVGYILGLGDRHLNNILLDcsTGEPIHIDLGIAFDQGKL-LPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVL 2680 Saccharomyces...
CCH60552     2681 SIIGFVLGLGDRHLNNILIDshSGEPIHIDLGIAFDQGRL-LPIPETIPFRLTRDIINGFGVTGVEGLFRKNCEYTYSVL 2759 Tetrapisispor...
EMH72366     2244 SIIGYVFGIGDRHNNNIMFDeaTAEVIHIDFGIVFEFGKK-LPIPEIVPFRLTREILDPMGVLKYDGPFKRCCENVLRIL 2322 Entamoeba his...
CBK22652      210 SIIGYIVGLGDRHLRNIMIDqkTGQLIHIDFGILFEKGRL-LSVPETVPFRLTREFVDCLGMEGVDGLLRQQMEFCMDLI 288  Blastocystis ...
EKX38308      199 SMVGYIVGLGDRHLSNILIDa-DRQLLHIDLGQVFDFARAtPRYPETVPFRLTRDMVDGMGMLGVEGSFIRCCIESMRVM 277  Guillardia th...
ELP92073     2266 SMVGYVLGIGDRHLNNIMFDkkTGELLHIDFGYIFEFGKK-LPCPEIVPFRLTRELQAPLGYLGVGSRFRATCVDVMNVL 2344 Entamoeba inv...
Feature 1                                 
AAF20175     1466 RNNQEALLTIVEVLLYDPLFDWTM 1489 African clawed frog
XP_001324760 2569 RKYSEYLLTVLDVFLRDPLHNWNV 2592 Trichomonas vaginalis G3
EEE31760     1810 RRVSPLVVSIVEVLLFDPLYRWCL 1833 Toxoplasma gondii VEG
CCH46977     2681 RENVEKIIGILNVLKYDPLYSWAI 2704 Wickerhamomyces ciferrii
P38110       2681 RKDYVKVMCVLNILKWDPLYSWVM 2704 Saccharomyces cerevisiae S288c
CCH60552     2760 RENHQKFLSVMNLLKWDPLYSWVM 2783 Tetrapisispora blattae CBS 6284
EMH72366     2323 RDNKDFVLAILQAVLSAPPKKWTD 2346 Entamoeba histolytica HM-1:IMSS-B
CBK22652      289 CKNKELILTILRVFLHDPLNLWKV 312  Blastocystis hominis
EKX38308      278 RENKNALLSVIDILLYESNLERLS 301  Guillardia theta CCMP2712
ELP92073     2345 RTNTDMVMAILDAVMSSPPKKWND 2368 Entamoeba invadens IP1

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