4M70


Conserved Protein Domain Family
RX-CC_like
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cd14798: RX-CC_like 
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Coiled-coil domain of the potato virux X resistance protein and similar proteins
The potato virus X resistance protein (RX) confers resistance against potato virus X. It is a member of a family of resistance proteins with a domain architecture that includes an N-terminal coiled-coil domain (modeled here), a nucleotide-binding domain, and leucine-rich repeats (CC-NB-LRR). These intracellular resistance proteins recognize pathogen effector proteins and will subsequently trigger a response that may be as severe as localized cell death. The N-terminal coiled-coil domain of RX has been shown to interact with RanGAP2, which is a necessary co-factor in the resistance response.
Links
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Statistics
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PSSM-Id: 271353
Aligned: 100 rows
Threshold Bit Score: 59.9431
Created: 11-Jun-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RanGAP2
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:RanGAP2 interaction site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      #  
4M70_A          6 AYAAVTSLMRTIHQSMELTG-------CDLQPFYEKLKSLRAILEKScni-----------mgdHEGLTILEVEIVEVAY 67   potato
XP_004239469  370 GLGSIDIILDQLEEFLSCYSeltssirSQIQKIQQQLEHFQKQNDGFgsf------------gmQVITKAYEVDHVVVGY 437  tomato
XP_004236955  355 KLGFSNCLLASLKEFLSGHSaslasvkDQIEVVHEELKFFEPFIMRLaeqa----------nnkHNELQNLVGRVIDKAY 424  tomato
AAC49408      951 GLGYLNCFLGKLEELLRSKLdliidlkHQIESVKEGLLCLRSFIDHFses-----------ydeHDEACGLIARVSVMAY 1019 tomato
AEQ29661       56 VEGLVKFLLNNLDRVFTCDAgsipfmkNQIPVVQENLVCLGSFLEHIvqh-----------rdmHRELKDLVERVQEVVN 124  potato
AAF76312      831 GKSFINIMLTQQDKVLDYDAgsvsyllNQISVVKDKLLHIGSLLVDIvqy-----------rnmHIELTDLAERVQDKNY 899  tomato
XP_004240304  441 GPIFMTFLLTNLKDLVDSNAssvalikEEIKQVKEDLEIIRSYFGYAe----------------QELHRDLWTRVLDVAY 504  tomato
AAZ95005      398 GPLFMHLLQRHLDDLLDSNAysialikEQIGLVKEDLEFIRSFFANIe----------------QGLYKDLWERVLDVAY 461  ornamental ni...
NP_001234836  388 GFLFMNLLLRHLKDLLISNAysvslikKEIGMVKQSLEFLTSSFGKVrktl----------dgtSGVVKDCWLHALDVAY 457  tomato
AFN86171      404 GWSFLDSLMRKLKEMSKSKScldflmkPLLGNLEKELSALTSILEKDlsslssilsdvakvhheHEILQDLHRRTINWAY 483  tomato

Feature 1          #  #                         #  #  ### ### ##             
4M70_A         68 TTEDMVDSESRNVFLaqnl-------eerSRAMWEIFFVLEQALECIDSTVKQWMATSD 119  potato
XP_004239469  438 INKDIPEWCLFLWTRdiieeitqlieageIHGKEVSDSVLHNTTDVANADTSQLAQMTS 496  tomato
XP_004236955  425 EVEYILDSFAISDVPlt----------flRMWLLEIIREIELIKTELTKPKEKNMTSAS 473  tomato
AAC49408     1020 KAEYVIDSCLAYSHPlwykv----lwiseVLENIKLVNKVVGETCERRNIEVTVHEVAK 1074 tomato
AEQ29661      125 SSKYVIFFSVSCDNPvw----------yhLLYLYDVKQVPKFVEEEVKMICFKVPDSSL 173  potato
AAF76312      900 ICFFSVKGYIPAWYY--------------TLYLSDVKQLLKFVEAEVKIICLKVPDSSS 944  tomato
XP_004240304  505 ETEHAINSILARDHGll----------qlIFVLLDIVKKIKLVRKEVQEKIPKSSGIIV 553  tomato
AAZ95005      462 EAKDVIDSIIVRDNGll----------hlIFSLPITRKKMMLIKEEVSDLHENISKNRG 510  ornamental nightshade
NP_001234836  458 EAEHVINSILVRDKPls----------hlIFSLPNVTDKIKLIVAQVTGLQLEDMNGDE 506  tomato
AFN86171      484 EAEVAIDSILAQYNVfw----------hiFCSLPTILKEIKQINVQVTQMWSADIALKP 532  tomato

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