1BKN,3NA3,1EA6,3H4L


Conserved Protein Domain Family
mutl

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TIGR00585: mutl 
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DNA mismatch repair protein MutL
All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273155
Aligned: 23 rows
Threshold Bit Score: 296.089
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1BKN_A     4 MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGA--TRIDIDIERGGAKlIRIRDNGCGIKKDELALALARHATS 81   Escherichia coli K-12
P38920     3 LRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANA--TMIDILVKEGGIKvLQITDNGSGINKADLPILCERFTTS 80   Saccharomyces cere...
CAB07283  23 GLIQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAGA--TEIMVNMQNGGLKlLQVSDNGKGIEREDFALVCERFATS 100  Caenorhabditis ele...
P14242     2 TQIHQINDIDVHRITSGQVITDLTTAVKELVDNSIDANA--NQIEIIFKDYGLEsIECSDNGDGIDPSNYEFLALKHYTS 79   Saccharomyces cere...
P54278    13 KAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGA--TNIDLKLKDYGVDlIEVSDNGCGVEEENFEGLTLKHHTS 90   human
P54280     2 STVKPIDANTVHKICSGQVITDVASAVKELVENSLDSGA--TTIEIRFKNYGINsIEVVDNGSGIDAGDYESIGKKHFTS 79   Schizosaccharomyce...
P54277     1 --MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGA--TSVDVKLENYGFDkIEVRDNGEGIKAVDAPVMAMKYYTS 76   human
CAA97559   1 MTIHQLSPESQWKIVSSSFIYGPVAAVRELLDNSIDSGAkkVFIDVDSTTGGCEyISVKDDGSGVDIIDRPSMCLEYTTS 80   baker's yeast
3NA3_A     7 GVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKS--TSIQVIVKEGGLKlIQIQDNGTGIRKEDLDIVCERFTTS 84   human
1EA6_A    13 KAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGA--TNIDLKLKDYGVDlIEVSDNGCGVEEENFEGLTLKHHTS 90   human
1BKN_A    82 KIASLDDLEAIISLGFRGEALASISSVSRLTLTSRT-----AEQQEAWQAy--aE-GRdMNVTVKPAAHPVGTTLEVLDL 153  Escherichia coli K-12
P38920    81 KLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKV-----KEDRCAWRVsy-aE-GK-MLESPKPVAGKDGTTILVEDL 152  Saccharomyces cere...
CAB07283 101 KLQKFEDLMHMKTYGFRGEALASLSHVAKVNIVSKR-----ADAKCAYQAnf-lD-GK-MTADTKPAAGKNGTCITATDL 172  Caenorhabditis ele...
P14242    80 KIAKFQDVAKVQTLGFRGEALSSLCGIAKLSVITTTsp--pKADKLEYDM----V-GH--ITSKTTTSRNKGTTVLVSQL 150  Saccharomyces cere...
P54278    91 KIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHas-akVGTRLMFDH----N-GK--IIQKTPYPRPRGTTVSVQQL 162  human
P54280    80 KITDFEDLEALQTFGFRGEALSSLCAVGQVIISTATqneapKGVQLNLDH----E-GS--LKDKLTIPFQRGTSVMVNDL 152  Schizosaccharomyce...
P54277    77 KINSHEDLENLTTYGFRGEALGSICCIAEVLITTRT-----AADNFSTQYv--lD-GSgHILSQKPSHLGQGTTVTALRL 148  human
CAA97559  81 KMSSLGDISILTTLGFRGEALFLLSNLCNQKGSMQVet-ktADDVIGEKWlvdsK-GGiTNGKRYKVSCPVGTTVILRKL 158  baker's yeast
3NA3_A    85 KLQSFEDLASISTYGFRGEALASISHVAHVTITTKT-----ADGKCAYRAsy-sD-GK-LKAPPKPCAGNQGTQITVEDL 156  human
1EA6_A    91 KIQEFADLTQVETFGFRGEALSSLCALSDVTISTCH-----ASAKVGTRLm--fDhNG-KIIQKTPYPRPRGTTVSVQQL 162  human
1BKN_A   154 FYNTPARRK-Fl--RTEKTEFNHIDEIIRRIALARFDVTINLSH---N---GKIVRQYRAVPEGGQKER---RLGAICGT 221  Escherichia coli K-12
P38920   153 FFNIPSRLR-Al--RSHNDEYSKILDVVGRYAIHSKDIGFSCKK---F---GDSNYSLSVKPSYTVQD----RIRTVFNK 219  Saccharomyces cere...
CAB07283 173 FYNLPTRRN-Km--TTHGEEAKMVNDTLLRFAIHRPDVSFALRQ--------NQAGDFRTKGDGNFRD----VVCNLLGR 237  Caenorhabditis ele...
P14242   151 FHNLPVRQKeFs--KTFKRQFTKCLTVIQGYAIINAAIKFSVWNit---pkGKKNLILSTMRNSSMRKN----ISSVFGA 221  Saccharomyces cere...
P54278   163 FSTLPVRHKeFq--RNIKKEYAKMVQVLHAYCIISAGIRVSCTN---QlgqGKRQPVVCTGGSPSIKEN----IGSVFGQ 233  human
P54280   153 FCTLPVRRKlLe--KNYKREFSKAISLLQAYATISTNKRFMVYH---QtknSGKLLQLSTNSNKDMKLN----IMNVFGT 223  Schizosaccharomyce...
P54277   149 FKNLPVRKQfYstaKKCKDEIKKIQDLLMSFGILKPDLRIVFVH---N----KAVIWQKS-RVSDHKMA----LMSVLGT 216  human
CAA97559 159 LGGLRARYLeIs--SRPRKTFDELIYLINHYSLIHRNIRFYFSL---Vs--LQKNGAIERKQMQETLDPkisRARSLSLL 231  baker's yeast
3NA3_A   157 FYNIATRRK-Al--KNPSEEYGKILEVVGRYSVHNAGISFSVKK---Q---GETVADVRTLPNASTVDN----IRSIFGN 223  human
1EA6_A   163 FSTLPVRHKeFq--RNIKKEYAKMVQVLHAYCIISAGIRVSCTNqlgQ---GKRQPVVCTGGSPSIKEN----IGSVFGQ 233  human
1BKN_A   222 AFLEQALAIe--W-QHGD-----------------LTLR----------------------GWVADPNHTTPALAEI--- 256  Escherichia coli K-12
P38920   220 SVASNLITFh-iS-KVED-----------------LNLEsv-------------------dGKVCNLNFISKKSIS---- 257  Saccharomyces cere...
CAB07283 238 DVADTILPLs--L-NSTR-----------------LKFTf--------------------tGHISKPIASATAAIAQnrk 277  Caenorhabditis ele...
P14242   222 GGMRGLEEVd-lV-LDLN-----------------PFKNrmlgkytddpdfldldykirvkGYISQNSFGCGRNSKDr-- 280  Saccharomyces cere...
P54278   234 KQLQSLIPFv-qL-PPSD-----------------SVCEeyglscsda-----lhnlfyisGFISQCTHGVGRSSTDr-- 287  human
P54280   224 KVSSSLIPWn-------D-----------------GIIE----------------------GYISRPHVGSTRASNEr-- 255  Schizosaccharomyce...
P54277   217 AVMNNMESFq-yHsEESQ-----------------IYLS----------------------GFLPKCDADHSFTSLStp- 255  human
CAA97559 232 ARLKKPVPLn-fIvEENF-----------------VIDEki------------------nlDLILPRMVPESDVINIkr- 274  baker's yeast
3NA3_A   224 AVSRELIEIgceD-KTLA-----------------FKMN----------------------GYISNANYSVKKCI----- 258  human
1EA6_A   234 KQLQSLIPFv-qL-PPSDsvceeyglscsdalhnlFYIS----------------------GFISQCTHGVGRSSTDr-- 287  human
1BKN_A   257 -----QYcYVNGRMMRDRL-----INHAIRQACEDKLGADQ---QPAFVLYLEIDPHQVDVNVHPAKHEVR 314  Escherichia coli K-12
P38920   258 -----PIfFINNRLVTCDL-----LRRALNSVYSNYLPKGN---RPFIYLGIVIDPAAVDVNVHPTKREVR 315  Saccharomyces cerevisiae S288c
CAB07283 278 tsrsfFSvFINGRSVRCDI-----LKHPIDEVLGAR--QLH---AQFCALHLQIDETRIDVNVHPTKNSVI 338  Caenorhabditis elegans
P14242   281 -----QFiYVNKRPVEYST-----LLKCCNEVYKTFN-NVQ---FPAVFLNLELPMSLIDVNVTPDKRVIL 337  Saccharomyces cerevisiae S288c
P54278   288 -----QFfFINRRPCDPAK-----VCRLVNEVYHMYN-RHQ---YPFVVLNISVDSECVDINVTPDKRQIL 344  human
P54280   256 -----QMlFINRRLVNLPK-----IARVIQEVFKPYS-MAQ---SPFFAINLRITNGTIDINVSPDKKSVF 312  Schizosaccharomyces pombe 9...
P54277   256 ---erSFiFINSRPVHQKD-----ILKLIRHHYNLKCLKEStrlYPVFFLKIDVPTADVDVNLTPDKSQVL 318  human
CAA97559 275 ---rfKFlSVNERALSLNLetgktISKLLSSIYRDFSLLDP----MVWFINLNCDTKLLDVNIEPEKNDVM 338  baker's yeast
3NA3_A   259 -----FLlFINHRLVESTS-----LRKAIETVYAAYLPKNT---HPFLYLSLEISPQNVDVNVHPTKHEVH 316  human
1EA6_A   288 -----QFfFINRRPCDPAK-----VCRLVNEVYHMYN-RHQ---YPFVVLNISVDSECVDINVTPDKRQIL 344  human
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