4L3V


Conserved Protein Domain Family
cysta_beta

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TIGR01137: cysta_beta 
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cystathionine beta-synthase
Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]
Statistics
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PSSM-Id: 273464
Aligned: 6 rows
Threshold Bit Score: 713.112
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4L3V_B        75 ILPDILKKIGDTPMVRINKIGKkfGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPG-DTIIEPTSGNTGIGL 153 human
CAB89449       3 FHDSMISLVGNTPLVRLNSVSK--GIRATVLAKVEYFNPGGSVKDRIALRMIEAAEKSGELQPG-GTIVEPTSGNTGVGL 79  Streptomyces co...
AAA19874      76 ILPDILKKIGDTPMVRINKIGKkfGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPG-DTIIEPTSGNTGIGL 154 human
P32582        10 SRHNVIDLVGNTPLIALKKLPKalGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSrSTLIEPTSGNTGIGL 89  Saccharomyces c...
AAA70099      32 IMDNILDNIGGTPLVRVNKVSS--DLECELVAKCEFFNAGGSVKDRIGHRMIVDAEESGRIKKG-DTLIEPTSGNTGIGL 108 Dictyostelium d...
WP_003405730   3 IAQHISELIGGTPLVRLNSVVP--DGAGTVAAKVEYLNPGGSSKDRIAVKMIEAAEASGQLKPG-GTIVEPTSGNTGVGL 79  Mycobacterium t...
4L3V_B       154 ALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHiLDQYRNASNPLAHYD 233 human
CAB89449      80 AIVAQQKGYKCIFVCPDKVSTDKINVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPGAWkPDQYSNPNNPLSHYH 159 Streptomyces co...
AAA19874     155 ALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHiLDQYRNASNPLAHYD 234 human
P32582        90 ALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAViLDQYNNMMNPEAHYF 169 Saccharomyces c...
AAA70099     109 ALTAAIKGYKMIITLPEKMSQEKVDVLKALGGEIIRTPTEAAFDAPESHIGVAKKLNSEIPNSHiLDQYGNPSNPLAHYD 188 Dictyostelium d...
WP_003405730  80 ALVAQRRGYKCVFVCPDKVSEDKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWkPDQYANPEGPASHYV 159 Mycobacterium t...
4L3V_B       234 TTADEILQQCDG-----KLDMLVASVGTGGTITGIARKLK-E-KCPGCRIIGVDPEGSILAEPeelnqTEQtTYEVEGIG 306 human
CAB89449     160 STGPELWEQTEG-----KITHFVAGVGTGGTISGTGRYLKdA-SDGAVTVIGADPEGSVYSGG-----SGR-PYLVEGVG 227 Streptomyces co...
AAA19874     235 TTADEILQQCDG-----KLDMLVASVGTGGTITGIARKLK-E-KCPGCRIIGVDPEGSILAEPeelnqTEQtTYEVEGIG 307 human
P32582       170 GTGREIQRQLEDlnlfdNLRAVVAGAGTGGTISGISKYLK-E-QNDKIQIVGADPFGSILAQPenlnkTDItDYKVEGIG 247 Saccharomyces c...
AAA70099     189 GTAEELLEQCEG-----KIDMIVCTAGTGGTITGIARKIK-E-RLPNCIVVGVDPHGSILAQPeslnnTNKs-YKIEGIG 260 Dictyostelium d...
WP_003405730 160 TTGPEIWADTEG-----KVTHFVAGIGTGGTITGAGRYLK-EvSGGRVRIVGADPEGSVYSGG-----AGR-PYLVEGVG 227 Mycobacterium t...
4L3V_B       307 YDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQ---ELQEGqRCVVILPDSVRNYMTK 383 human
CAB89449     228 EDFWPTAYDREVADEIVAVSDKDSFQMTRRLAKEEGLLVGGSCGMAVVAALEVAAr--LGEDD-VVVVLLPDSGRGYLSK 304 Streptomyces co...
AAA19874     308 YDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQ---ELQEGqRCVVILPDSVRNYMTK 384 human
P32582       248 YDFVPQVLDRKLIDVWYKTDDKPSFKYARQLISNEGVLVGGSSGSAFTAVVKYCEdhpELTEDdVIVAIFPDSIRSYLTK 327 Saccharomyces c...
AAA70099     261 YDFIPNVLERKLVDQWIKTDDKESFIMARRLIKEEGLLCAGSSGSAMVGALLAAK---QLKKGqRCVVLLADSIRNYMTK 337 Dictyostelium d...
WP_003405730 228 EDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEe--AGPDA-LIVVLLPDGGRGYMSK 304 Mycobacterium t...
4L3V_B       384 FLSDRWMLQKGFLKE------EDLTEKKPwww------------hlRVQELGLSAPLTVLPTITCGHTIEILREKGFDQA 445 human
CAB89449     305 IFNDEWMADYGFLEDt----gPSARVAEVl---------------nHKEGGHIPSLVHMHPDETVGQAIEVLREYGVSQM 365 Streptomyces co...
AAA19874     385 FLSDRWMLQKGFLKE------EDLTEKKPwww------------hlRVQELGLSAPLTVLPTITCGHTIEILREKGFDQA 446 human
P32582       328 FVDDEWLKKNNLWDD------DVLARFDSskleasttkyadvfgnaTVKDLHLKPVVSVKETAKVTDVIKILKDNGFDQL 401 Saccharomyces c...
AAA70099     338 HLNDDWLVDNGFVDP------EYKTKDQQeeek---------yhgaTVKDLTLPKPITISATTTCAAAVQLLQQYGFDQL 402 Dictyostelium d...
WP_003405730 305 IFNDAWMSSYGFLRSrldgstEQSTVGDVl----------------RRKSGALPALVHTHPSETVRDAIGILREYGVSQM 368 Mycobacterium t...
4L3V_B       446 PVVD--------EAGVILGMVTLGNMLSSLLAGKVQPSDQVG------KVIY---------------KQFKQIRLTDTLG 496 human
CAB89449     366 PIVKpgaghpdvMAAEVVGSVVERELLDALFAKRASLEDPLE------KHMS---------------APLPQVGSGEPVA 424 Streptomyces co...
AAA19874     447 PVVD--------EAGVILGMVTLGNMLSSLLAGKVQPSDQVG------KVIY---------------KQFKQIRLTDTLG 497 human
P32582       402 PVLT--------EDGKLSGLVTLSELLRKLSINNSNNDNTIKgkyldfKKLNnfndvssynenksgkKKFIKFDENSKLS 473 Saccharomyces c...
AAA70099     403 PVVS--------ESKKVLVNSLLVTSLT-YASKKAVPTDAVS------KVMFrft----------knEKYIPITQSTSLA 457 Dictyostelium d...
WP_003405730 369 PVVGaep---pvMAGEVAGSVSERELLSAVFEGRAKLADAVS------AHMS---------------PPLRMIGAGELVS 424 Mycobacterium t...
4L3V_B       497 RLSHILEMDHFALVVHEQIQyhstgkssqrqmvFGVVTAIDLLNFVA 543 human
CAB89449     425 DLMSVLGGADAAIVLVEGKP-------------TGVVSRQDLLSFLA 458 Streptomyces coelicolor A3(2)
AAA19874     498 RLSHILEMDHFALVVHEQIQyhstgkssqrqmvFGVVTAIDLLNFVA 544 human
P32582       474 DLNRFFEKNSSAVITDGLKP-------------IHIVTKMDLLSYLA 507 Saccharomyces cerevisiae S288c
AAA70099     458 TLSKFFENHSSAIVTENDEI-------------ISIVTKIDLLTYLM 491 Dictyostelium discoideum
WP_003405730 425 AAGKALRDWDALMVVEEGKP-------------VGVITRYDLLGFLS 458 Mycobacterium tuberculosis complex
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