4DB1


Conserved Protein Domain Family
MYSc_Myh7
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cd14917: MYSc_Myh7 
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class II myosin heavy chain 7, motor domain
Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276881
Aligned: 28 rows
Threshold Bit Score: 1328.19
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #########                                           #
4DB1_A      99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  human
P13540      98 PAVLYNLKDGYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPAHIFSISDNAYQYMLTDRENQsILITG 177  golden hamster
NP_058936   99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAQVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  Norway rat
NP_542766   99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  house mouse
BAE34176    99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  house mouse
Q91Z83      99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  house mouse
P49824      99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  dog
EDL36311    99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  house mouse
EDM14211    99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  Norway rat
AAI58071    99 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQsILITG 178  house mouse

Feature 1      #######                                               ###########               
4DB1_A     179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  human
P13540     178 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 257  golden hamster
NP_058936  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  Norway rat
NP_542766  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  house mouse
BAE34176   179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  house mouse
Q91Z83     179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  house mouse
P49824     179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  dog
EDL36311   179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  house mouse
EDM14211   179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  Norway rat
AAI58071   179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258  house mouse

Feature 1                                                                                      
4DB1_A     259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338  human
P13540     258 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFIPQGETTVASIDDSEELMATDSAFDV 337  golden hamster
NP_058936  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFFSQGETTVASIDDSEEHMATDSAFDV 338  Norway rat
NP_542766  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDV 338  house mouse
BAE34176   259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDV 338  house mouse
Q91Z83     259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDV 338  house mouse
P49824     259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDNAFDV 338  dog
EDL36311   259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDV 338  house mouse
EDM14211   259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDV 338  Norway rat
AAI58071   259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDV 338  house mouse

Feature 1                                                                                      
4DB1_A     339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  human
P13540     338 LGFTSEEKNSIYKLTGAIMHFGNMKFKQKQREEQADRDGTEEEDKSAYLMGLNSADLLKGMCHPRVKVGNEYVTKGQNVQ 417  golden hamster
NP_058936  339 LGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  Norway rat
NP_542766  339 LGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  house mouse
BAE34176   339 LGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  house mouse
Q91Z83     339 LGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  house mouse
P49824     339 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  dog
EDL36311   339 LGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  house mouse
EDM14211   339 LGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  Norway rat
AAI58071   339 LGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418  house mouse

Feature 1                                                ######                                
4DB1_A     419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  human
P13540     418 QVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 497  golden hamster
NP_058936  419 QVAYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  Norway rat
NP_542766  419 QVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  house mouse
BAE34176   419 QVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  house mouse
Q91Z83     419 QVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  house mouse
P49824     419 QVAYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  dog
EDL36311   419 QVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  house mouse
EDM14211   419 QVAYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  Norway rat
AAI58071   419 QVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498  house mouse

Feature 1                                                                                      
4DB1_A     499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKgkpEAHFS 578  human
P13540     498 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMRIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKgkqEAHFS 577  golden hamster
NP_058936  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKgkqEAHFS 578  Norway rat
NP_542766  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKgkqEAHFS 578  house mouse
BAE34176   499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKgkqEAHFS 578  house mouse
Q91Z83     499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKgkqEAHFS 578  house mouse
P49824     499 EEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKgkqEAHFS 578  dog
EDL36311   499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKgkqEAHFS 578  house mouse
EDM14211   499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKgkqEAHFS 578  Norway rat
AAI58071   499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKgkqEAHFS 578  house mouse

Feature 1                                                                                      
4DB1_A     579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYagadapieKGKGKAKKGSSFQTVSALHRENLNKL 658  human
P13540     578 LVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapvdKGKGKAKKGSSFQTVSVLHRENLNKL 657  golden hamster
NP_058936  579 LIHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapvdKGKGKAKKGSSFQTVSALHRENLNKL 658  Norway rat
NP_542766  579 LVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapadKGKGKAKKGSSFQTVSALHRENLNKL 658  house mouse
BAE34176   579 LVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapadKGKGKAKKGSSFQTVSALHRENLNKL 658  house mouse
Q91Z83     579 LVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapadKGKGKAKKGSSFQTVSALHRENLNKL 658  house mouse
P49824     579 LIHYAGTVDYNILGWLQKNKDPLNETVVALYQKSSLKLLSNLFANYagadapveKGKGKAKKGSSFQTVSALHRENLNKL 658  dog
EDL36311   579 LVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapadKGKGKAKKGSSFQTVSALHRENLNKL 658  house mouse
EDM14211   579 LIHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapvdKGKGKAKKGSSFQTVSALHRENLNKL 658  Norway rat
AAI58071   579 LVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagadapadKGKGKAKKGSSFQTVSALHRENLNKL 658  house mouse

Feature 1                                                                                      
4DB1_A     659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  human
P13540     658 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 737  golden hamster
NP_058936  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  Norway rat
NP_542766  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  house mouse
BAE34176   659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  house mouse
Q91Z83     659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  house mouse
P49824     659 MTNLRSTHPHFVRCIIPNETKSPGVIDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  dog
EDL36311   659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  house mouse
EDM14211   659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  Norway rat
AAI58071   659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738  house mouse

Feature 1                                  
4DB1_A     739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766  human
P13540     738 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 765  golden hamster
NP_058936  739 RKGAEKLLGSLDIDHNQYKFGHTKVFFK 766  Norway rat
NP_542766  739 RKGAEKLLGSLDIDHNQYKFGHTKVFFK 766  house mouse
BAE34176   739 RKGAEKLLGSLDIDHNQYKFGHTKVFFK 766  house mouse
Q91Z83     739 RKGAEKLLGSLDIDHNQYKFGHTKVFFK 766  house mouse
P49824     739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766  dog
EDL36311   739 RKGAEKLLGSLDIDHNQYKFGHTKVFFK 766  house mouse
EDM14211   739 RKGAEKLLGSLDIDHNQYKFGHTKVFFK 766  Norway rat
AAI58071   739 RKGAEKLLGSLDIDHNQYKFGHTKVFFK 766  house mouse

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