1BBC,3ELO


Conserved Protein Domain Family
Phospholip_A2_1
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pfam00068: Phospholip_A2_1 (this model, PSSM-Id:278496 is obsolete and has been replaced by 459659)
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Phospholipase A2
Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.
Links
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Statistics
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PSSM-Id: 278496
Aligned: 139 rows
Threshold Bit Score: 68.4104
Created: 13-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1BBC_A         4 NFHRMIKLTT-GKeAALSYGFYGCHC------GV--------GGRGSPKDATDRCCVTHDCCYKRLE---K---R----- 57  human
XP_006634591 359 iLGEILHCLT-GR-CPHEYEMYGCYC------GQ--------EGRGRPMDELDRCCFFHQCCLEQIR---M---F----- 411 spotted gar
XP_006634591 116 NFMQKLKCTT-KL-CPRDLEDYGCSC------RY--------EEEDRPIDDIDSCCSQHRRCYKAAA---E---K----- 168 spotted gar
XP_005628019  76 QFVSGMKCVA-GL-CPRDFEDYGCAC------RF--------EMEGAPVDEADSCCFQHRRCYEEAA---E---K----- 128 dog
XP_008106401  80 NFVNKMKCVT-GI-CPRDFEDYGCAC------RF--------EMEGLPVDEVDDCCFQHRKCYEEAT---D---E----- 132 green anole
CBY14648     110 QMKIVILFMQkNK-FLGKYCFYGCWCfprgagNN--------GGFGQPVDNIDKSCREYSTCYNCIY---N---Qnigsq 174 Oikopleura dioica
CBY09558      36 NLADLLEYYIpET-DASQYLSYGCNC------NLleskglasPGHGAAVDQIDQACKNYKDCQRCVQiedG---S----- 100 Oikopleura dioica
CBY31053     107 tLKLMIMYLQtLP-LFGKFCYYGCYCfpnagdDFt-------VGRGTPVDEVDKKCRDFSSCYKCVA---NdfkE----- 170 Oikopleura dioica
CBY09052      41 QFESMAKLFDpDF-DKKSITDYGCNCpelgdrPLs------dPGKGQPVDELDTVCQKFKQCAKCAK---EefgE----- 105 Oikopleura dioica
CBY07132     199 QLLNMMVRYNpEF-DERKYFSYGCNCqffgdrPMs------gPGGGPPMDPLDRTCREYRNCQKCTR---MefgD----- 263 Oikopleura dioica

1BBC_A        58 GC--G-TKFLSYKF-----SNSGSR-ITC---Ak-qDSCRSQLCECDKAAATCFARNKTTYNKKYQ 110 human
XP_006634591 412 GCr-A-ERKLNIQV-----SCDNGQ-PAC---Ag-aNMCDKLQCMCDKASAECMA--GAHFNETva 463 spotted gar
XP_006634591 169 DCklQ-PGRILLNT-----TCPAGN-ITC---Da-sDFCEEFFCLCDKAVIECIAHSQ--YNSSLR 221 spotted gar
XP_005628019 129 DCp-QdPAKLSIDV-----NCVSKS-ITC---Es-gDPCEHLLCTCNKAAIECLARSsinsslnhl 183 dog
XP_008106401 133 ECmwD-PAKLTMDV-----SCLTKN-LTC---Es-eDSCELFLCNCDKAAIECFLHSR--FNSSmn 185 green anole
CBY14648     175 RCp-E-NTADRYQIggfvdRFGQVQ-IFC---TdpwGTCNRSRCECDRDLAMKLRQHEPEWNMQYH 234 Oikopleura dioica
CBY09558     101 ECnlE-GPSALYKL-----GFLSDQ-PYC---MnpvKSCNRHLCECDKQFAEELKQALPFYDSQFs 156 Oikopleura dioica
CBY31053     171 TC----KHTQPYSFegredpvTGTRyLVCkntP---GTCRRSLCECDKRLAEELAANEWFWVPMNH 229 Oikopleura dioica
CBY09052     106 SC--I-SEMIRYGL----------RgKTCtdsA---GTCARALCECDLSFAEALSFVDKESNQDQY 155 Oikopleura dioica
CBY07132     264 QC--R-GEFVKYSEtq----dTQGN-FKCgdeA---GTCARAICECDHRFAKNHVEKTDSYNVDNH 318 Oikopleura dioica
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