2L5S,3EVS


Conserved Protein Domain Family
Activin_recp
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pfam01064: Activin_recp (this model, PSSM-Id:279413 is obsolete and has been replaced by 460048)
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Activin types I and II receptor domain
This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.
Links
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Statistics
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PSSM-Id: 279413
Aligned: 22 rows
Threshold Bit Score: 47.0987
Created: 20-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2L5S_A          6 LQC-F-CHL----------CT--KDN-----FT----CVT-------------------D----GLCFVSVTEtTDK--- 36   human
Q7QJY6         30 YKC-YsCEPp--------dCA--DTAih--aHY----CQN-------------------A----IQCWKSRTR-DPEg-- 66   Anopheles gam...
Q04771         33 YMC-V-CEGl--------sCG--NE------DH----CE--------------------G----QQCFSSLSInDGf--- 63   human
Q24468         34 iEC-EhFDEk--------mCN--TT------QQ----CETriehck--------meadkF----PSCYVLWSVnETTg-- 78   fruit fly
O35607         32 RLC-AfKDPyqq----dlgIGesRIShengtIL----CSK-------------------G----STCYGLWEKsKGDi-- 77   house mouse
O16623        283 VSC-F-CNTd--------kCN--DDSfeiptDV----VLTvppvmkcfeddlnednycyG----HYCIYERDLtRNEfgd 342  Caenorhabditi...
P70539         26 LKC-V-CLL----------CD--SSN-----FT----CQT-------------------E----GACWASVMLtNGk--- 56   Norway rat
NP_001093904   20 LTC-Y-CGGsre----npyCE--RNV-----FN----CTVp------------------E----GVCYAMTEVlPISk-- 58   vase tunicate
AAB22238       28 RECiY-YNAnw-------eLE--KTN-----QSgvesCEG-------------------EkdkrLHCYASWRNnSGf--- 70   African clawe...
XP_001237683   91 NGQ-EfVDDydsyddqpepSD--EPVfeknvST----VATcs---------------rtA----PFCYTLWTFdIv---- 140  Anopheles gam...

2L5S_A         37 -VIHNS----MCIAEIDLIPrdrpFVCAPs-----------------Sk---tGSVTTTyCCnQDHCNKIELPT 85   human
Q7QJY6         67 nENVQR----GCTTEHEQLP----LYCSQnqkpntgdsggpkkrhvsSt---gMYNIEC-CT-GDYCNNGSFPE 127  Anopheles gambiae s...
Q04771         64 -HVYQK----GCFQVYEQGK----MTCKTp-----------------Ps---pGQAVEC-CQ-GDWCNRNITAQ 106  human
Q24468         79 iLRIKMk---GCFTDMHECNq---TECVTs-----------------Aep-rqGNIHFC-CCkGSRCNSNQKYi 127  fruit fly
O35607         78 -NLVKQ----GCWSHIGDPQechyEECVVtt---------------tPpsiqnGTYRFC-CCsTDLCNVNFTEN 130  house mouse
O16623        343 vFPRTAkprrGCSDPNYTQDlsrkNMCKI------------------E-----NDWLQC-ICdTEFCNREQNIE 392  Caenorhabditis elegans
P70539         57 -EQVSK----SCVSLPELNAq---VFCHS------------------Sn---nVTKTEC-CF-TDFCNNITQHL 99   Norway rat
NP_001093904   59 nILTQR----GCFRKNRLVPynrpFVCEPv-----------------Nk---sNHQVIC-Ck-TDFCNHPEAME 106  vase tunicate
AAB22238       71 iELVKK----GCWLDDFNCYd--rQECIAk-----------------Ee---nPQVFFC-CCeGNYCNKKFTHL 117  African clawed frog
XP_001237683  141 -KNVTRvvvqGCWGSNDDQEscssNECVStte-------------------tpTRHFFC-CCsGDNCNGNFSYL 193  Anopheles gambiae s...
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