Conserved Protein Domain Family
HNF-1B_C
?
pfam04812: HNF-1B_C (this model, PSSM-Id:282643 is obsolete and has been replaced by 461438)
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Links
?
Statistics
?
PSSM-Id: 282643
Aligned: 10 rows
Threshold Bit Score: 291.145
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q90867       285 AMDNFSGPQPTSAPP-LTPHNSSSLqPPPALSP--TKVH-GVRYNQQPASEAESSSS-NHHGNS--SMVTT-QTILHQVS 356 chicken
XP_011230193 314 AMDAYSSNHTHNLNP-LLSHGSPHH-QPSASPP--NKLS-GVRYSQPGNNEVTSASTiSHHGNS--AMVTS-QSVLQQVS 385 giant panda
XP_003228872 365 AMDAYSTGQPHTMNL-LLSHNSPHHvQASASPP--SKMT-GVRYGQAGPNDVPSSSSiGHHVNStsAMVTSsQAILQQVS 440 green anole
XP_006640975 193 AMDAYSGAPSHGMNS-LLSHSSPHQpPASTSPP--SKMQ-GVRYSQQGASEVTSSTTiSHHGNN--VMATS-QSVLQQVS 265 spotted gar
XP_007248687 322 AMDAYSG-QTHSMNS-LLSHSSPHHpQASTSPP--SKMQ-AVRYNQ-GPGEVSSSTTiSHHSGN--GMTSG-QSVLQQIS 392 Mexican tetra
XP_005987273 286 AMDSYSNQQPNTVTP-VTPHNTSl--QHGALSP--NKVQvGVRYGQQSTSDDMSPSv-SHHGNS--AMVTT-QTILQQVS 356 coelacanth
XP_011606849 323 AMDAI-NAQPHSINP-LLSHSSPHHpQNSASSP--------IRYSQ-GPGEVTSSTTiSHHSSN--AMPSG-QSVLQQVS 388 torafugu
XP_006151581 282 AMDTYSGPPPGPGPGpTLPAHSSPGlPPPALSP--SKVH-GVRYGQPANSEAADVPSsSGG-----PLVTV-SAPLHQVS 352 Chinese tree shrew
CAG02502     279 ALDAPFS-QPSSANH-ALPTSPEP----------------GVKYSPQMLCDGVTSARlAGGDRT--G--------CLVVS 330 spotted green p...
XP_005474815 192 AMDAITA-PSHGINP-LLSHGSPHHpQASASPPmrYG---------QVPSEVTSSSAiSHHSSN--AMATS-QSVLQQVS 257 Nile tilapia

Q90867       357 PPGLEPSQN--LLSTDTKLISAPGGTLPPVSTLTALHSLeqnP---HALG---QQTQNLIMASLPGVMAIgagetsslap 428 chicken
XP_011230193 386 PASLDPGHN--LLSPDGKMISVSGGGLPPVSTLTNIHSL---S---HHNP---QQSQNLIMTPLSGVMAI---------- 444 giant panda
XP_003228872 441 PVGLDPGHGhgLLAPDGKMITVSGGGLPPVSTLTNIHSF---S---HHNP---SQSQNLIMAPLSGVMAI---------- 501 green anole
XP_006640975 266 PGGLDPSHS--LLSPDAKMISVSGGGLPPVSTLTNIHSL---SqssHHGH---QQTQNLIMTPLSGVMAI---------- 327 spotted gar
XP_007248687 393 PGALDPSHS--LLSPDAKMISGSGGGLPPVSTLTSMHG----P---HHAH---QQTQNLIM-PISGVMAI---------- 449 Mexican tetra
XP_005987273 357 SPGLEPSQS--LLTTDTKLISTSGGTLPPVSTLTALHSLhqnP---HTVT---QQTQNLIMASLPSVMAIgpgdtptltp 428 coelacanth
XP_011606849 389 PGGLDHSHS--LLSPDAKMIPGSGG-LPPVSTLTNIHS----S---HHSH---QQAQNLIM-PLSGVMAI---------- 444 torafugu
XP_006151581 353 PTGLEPSHS--LLSTEAKLVSTAGGPLPPVSTLTALHSL---E---QTSPglnQQPQNLIMASLPGVMTIgpgepaslgp 424 Chinese tree shrew
CAG02502     331 PVQLEPSHT--LLDTQNPKQVSSGGPLPPVSTLTSLHSL---S---ASPA---SSPSL-IMASLPSVMSLgesslliaev 398 spotted green p...
XP_005474815 258 PGGLDHSHS--LLSPDAKMISGSGGGLPPVSTLTNIHS----S---HHSH---QQtqNLIM-PLSGVMAI---------- 314 Nile tilapia

Q90867       429 rftntggSTlviGLTSTQPQSVPVINSMGSSLTTLQPVQFSQQLHPSYQQPLMQQVQ-SHINQSPFMATMAQIQNPHaLY 507 chicken
XP_011230193 445 -------AQ---SLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPgSHMTQQPFMAAVTQLQNSH-MY 513 giant panda
XP_003228872 502 -------TQ---SLNSSQAQTVPVINTVASSLAALQPVQFSQQLHSPHQQSLMQQSP-SPMAQPPFMATVTQLQNSH-MY 569 green anole
XP_006640975 328 -------TQ---SLNTSQAQSVPVINSVTGGLAALQPVQFPQQLHSPHQQSLMQQSP-SHMAQQPFMATVTQLQNSH-MY 395 spotted gar
XP_007248687 450 -------AQ---SLNTSQAQTVPVINSVAGSLATLQPVQFSQQLHSSHQQGLMQQSH-SHMSQQPFMATVT---HSH-MY 514 Mexican tetra
XP_005987273 429 slsntgpSTfviGLTTSQAPNVPVINNMGSSFATLQPVQFPQQLHSPHQQPIMQQVQ-GHMAPNSFMATMAQLQNPHaLY 507 coelacanth
XP_011606849 445 -------AQ---SLNTSQSQSVPVINSVTGSLAALQPVQFSQQLHSPHQQSLMQQSP-SHMSQQPFMATVT---HSH-MY 509 torafugu
XP_006151581 425 tftntgaSTlviGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ-SHVAQSPFMATMAQLQSPHaLY 503 Chinese tree shrew
CAG02502     399 nkgrhsgSGvvtGLASTQPQSVPVINNVGAGFTTLQPISFQQQLHASPQQPIPQHLQ-GHMGSSPFMATMAPLPC-H-MY 475 spotted green p...
XP_005474815 315 -------AQ---SLNTSQSQTVPVINSVAGSLAALQPVQFSQQLHSPHQQSLMQQSP-SHMSQQPFMASVT---HSH-MY 379 Nile tilapia

Q90867       508 GPKSEVAQYTHTGLLPQTMVITDTANLSALTNLTPTK 544 chicken
XP_011230193 514 THKQEPPQYSHTSRFPSAMVVTDTNSISTLTNMSSSK 550 giant panda
XP_003228872 570 SHKQEPPQYSHTSRFPSAMVVTDTSGITSLTNMSSSK 606 green anole
XP_006640975 396 SHKQEPPQYSHPSRYPSAMVVTDASSISTLASMPSSK 432 spotted gar
XP_007248687 515 SHKQEPPQYSHPSRFPSAMVVTDTNslstlssmssnk 551 Mexican tetra
XP_005987273 508 SHKPELPPYTPSGLFSSTMVITDTGNLSAITGLAPTK 544 coelacanth
XP_011606849 510 SHKQEPPQYSHPSRFPSTMVVTDANslstlssmsssk 546 torafugu
XP_006151581 504 SHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTK 540 Chinese tree shrew
CAG02502     476 --KSDSPQYPSSSLLSQALVIADSSSLGTLTSLTAVR 510 spotted green pufferfish
XP_005474815 380 PHKQEPPQYSHPSRFSSAMVVTDANsplssisssktd 416 Nile tilapia
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap