Conserved Protein Domain Family
GSK-3_bind
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pfam05350: GSK-3_bind (this model, PSSM-Id:283100 is obsolete and has been replaced by 428435)
Glycogen synthase kinase-3 binding
Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognizing and phosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein (this family) prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of beta-catenin by GSK-3.
Links
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Statistics
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PSSM-Id: 283100
Aligned: 8 rows
Threshold Bit Score: 271.817
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P70339         1 MPCRREEEEEAGDEAEGEED-D-D--SFLLLQQSVTLGGSTDVDQLIVQIGETLQLDAAHDRPASPCAAPGPP--PPQVL 74  house mouse
O75474         1 MPCRREEEEEAGEEAEGEEEeD-D--SFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQDSPASPCAPPGVPlrAPGPL 77  human
XP_003787348   1 MPCRREEEEEAGEEAEGEEE-K-D--SFLLLEQSVTLGSSGEVDKLVAQIGETLQLDAAQDSPASPCASLGAPlrAPRPQ 76  small-eared galago
XP_005343099   1 MPCRREEEEEAGEEAEGEEE-D-DddSFLLLKQSVTLEGSGEVDRLVAQIGQTLQLDAAHDSPASRCV---PPgpPLQPP 75  thirteen-lined ...
XP_003777658   1 MPCRREEEEEAGEEAEGEEE-EeD--SFLLLQQSVPLGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPlrAPGPL 77  Sumatran orangutan
EGW12134       1 MQCQRAEKEEGGFEAEGEDK-D-D--SFLLLQQSVTLGSLTDVDQLIALIGETLKLDTAHDGPASPSAA--PGppPLRVL 74  Chinese hamster
XP_002698461   1 MPCRREE---EEEAGEEEEE-E-D--SFLLLEQSVTVGGSVEVDRLVAQIGETLQLDAAQDRPASACAPPGPPlqPPRSP 73  cattle
XP_008268516   5 reeeeeageeaegeeeeeeeeeeeegSFLLLEQSVTLGGSGEVDRLVAQIGETLQLDAAQDSPASPCAPPGRHssSPRGL 84  rabbit

P70339        75 -AA-------LPADKTGT--PARRLLRPTGSAETGN-PAPPGAVRCVLGERGRVRGRSAPYCVAE--ISP---------- 131 house mouse
O75474        78 -AAa------VPADKARP--PAVPLLLPPASAETVG-PAPSGALRCALGDRGRVRGRAAPYCVAE--VAA---------- 135 human
XP_003787348  77 -AA-------VRADEGPA--AAVQLLLPPSSSEGVG-PAPPGALRCALGDRGRVRGRAAPYCVAE--LVA---------- 133 small-eared galago
XP_005343099  76 -VA-------LPADKARS--PAVPLLLRPVSAEAGG-LAPPGALRCALGDRGRVRGRAAPYCVAE--LSS---------- 132 thirteen-lined ...
XP_003777658  78 -AAavxxxxwTRRSTARPraPGVPLLLPPVSAETVG-PAPPGXLRCALGDRGRVRGRAAPYCVAE--LAT---------- 143 Sumatran orangutan
EGW12134      75 -AA-------ISVEQNRS--PSRQMLRSSVPAETGA-PAHPRAISCMLWERWRLRSQAAPYCVAE--LTA---------- 131 Chinese hamster
XP_002698461  74 -AA-------VRADKARA--PAQPLLLPAASIEAGG-PAPLGALRCALGDRGRVRGRAAPYFVAE--LAA---------- 130 cattle
XP_008268516  85 xGA-------VRADKAWS--PGVPLLPPPTLAEAVGpAPP-GAVRCALGDRGRVRGRAAPYCVAElaAGSnvlsplppqp 154 rabbit

P70339       132 ------GASALpqqpgldgppg---tgklstpqplsGPCRRGWLRNAAASRRLQQRRGSQPETRTGdDDDPHRLLQQLVL 202 house mouse
O75474       136 ------GPSALp------------------------GPCRRGWLRDAVTSRRLQQRRWTQAGARAG-DDDPHRLLQQLVL 184 human
XP_003787348 134 ------GPSALptlplqpgqdgplgagkrgvsqqlsGPCRRGWLRGAAASRRLQQRRGSQPETRTN-DDDPHRLLQQLVL 206 small-eared galago
XP_005343099 133 ------GPSALsplssqpgldgppgagkqgipqpltGPCRRGWLRSAAASRRLQQRRGSQPDTCTG-DDDPHRLLQQLVL 205 thirteen-lined ...
XP_003777658 144 ------GPSALsplppqadldgppgagkqgipqplsGPCRRGWLRGAAASRRLQQRRGSQPETRTG-DDDPHRLLQQLVL 216 Sumatran orangutan
EGW12134     132 ------VTSALcpvsrqpglegppvtgkpstpqplsGPCRRGWPQSTAMSLPLQQRPGSQPETHTS-DDDPHQLPQQLLL 204 Chinese hamster
XP_002698461 131 ------GPTALsplppqpsldgplgadkrgspqplsGPCRRGWLRDAAASRRLQHRRGLQPPARNG-DDDPHRLLQQLVL 203 cattle
XP_008268516 155 gldvppGagkqgi------------------pqplsGPCRRGWLRGAASSRRLQQRRGSQPETRTS-DDDPHRLLQQLVL 215 rabbit

P70339       203 SGNLIKEAVRRLHSRQLQLHAKLPAHPfLGP 233 house mouse
O75474       185 SGNLIKEAVRRLQRAVAAVAATGPASA-PGP 214 human
XP_003787348 207 SGNLIKEAVRRLHSRRLQLHTKLPQRPlLGP 237 small-eared galago
XP_005343099 206 SGNLIKEAVRRLHSRRLQLHAKLPQHRlLGP 236 thirteen-lined ground squirrel
XP_003777658 217 SGNLIKEAVRRLHSRRLQLRAKLPQRPlLGP 247 Sumatran orangutan
EGW12134     205 SGNLIKEAVQRLHSLQLQLQANLYSHRfLKr 235 Chinese hamster
XP_002698461 204 SGNLIKEAVRRLHSRRLQLHAKLPQRQlLGP 234 cattle
XP_008268516 216 SGNLIKEAVRRLHSRRLQLRPKLPPCQlPGP 246 rabbit
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