Conserved Protein Domain Family
Fez1

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pfam06818: Fez1 (this model, PSSM-Id:284284 is obsolete and has been replaced by 462015)
Fez1
This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.
Statistics
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PSSM-Id: 284284
Aligned: 39 rows
Threshold Bit Score: 201.307
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6DIS8       446 TKWEVCQKSGEISLLKQQLKDSQAELAQKSNEILLLRAQVREARSDLQISEE--------------QVQELQDTAHTKTL 511  western clawed...
XP_006006078 426 TKWEVCQKAGEISLLKQQLKDSQAEVSQKLNEIVGLRAQLKEAKALLRDKEE--------------QVLNLKDSYSSKSI 491  coelacanth
XP_005045711 710 TKWEVCQKAGEISLLKQQLKDSQADVSQKLNEIVGLRSQLKEGKNFLREKEE--------------QILTLKDSYSSKSV 775  collared flyca...
XP_002936402 417 TKWEVCQKAGEISLLKQQLKDCQADLSQKLNEIVGLRTQLKEAKAFLREKEE--------------QIASIKDSYSSKSV 482  western clawed...
XP_008760369 531 TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEE--------------QLLSLRDSFGSKQA 596  Norway rat
XP_002603684 318 TKWEMCQKSGEISLLKQQLKEAKSELSLKTNDVIASRGTIKDIKTELSEKDS--------------QVTALQDKVSEKNA 383  Florida lancelet
NP_001124350 205 TEWSLCQRAGEIALLKTQLKDAQNEQTTKGHEYLTLKADCRQLRETLDKKDK--------------EIMRLRAESDEKQK 270  domestic silkworm
EHJ78659     125 TEWSLCQRAGEIALLKTQLKEAQNEQTAKGHEYLTLKSDCRQLREALDKKDK--------------EILRLRAESEEKEK 190  monarch butterfly
EEZ98911     385 TEWGLCQKTGEISLLKSQLKDYQNEQTAKCQELLQLRTEHRDFREQLDLREA--------------EISELRHQSEEKDA 450  red flour beetle
XP_007243359 297 TKWEVCQKAGEISLLKQQLRDSQGEVTQRAGEMVALRNQLKELNAQLREREEaelslkesfctktlELERCEAELQAMLA 376  Mexican tetra
Q6DIS8       512 ELEVCENELQR------------K------------KNEAELLREKASKL---------DQEVAGLREA---------AV 549  western clawed...
XP_006006078 492 DLEVCENELQR------------K------------MNEVQLLREKLNQY---------ELEISGLKQG---------LA 529  coelacanth
XP_005045711 776 NLEICEGELQR------------K------------MSEVQVLREKLNHC---------ELEVSGLKRT---------LA 813  collared flyca...
XP_002936402 483 SLEICENEMQR------------K------------QSEAQQMKEKLSQC---------EQEISSLKEA---------LA 520  western clawed...
XP_008760369 597 SLELSEGELPP------------A------------CLKPALTP----------------VDLVEPQEA---------LA 627  Norway rat
XP_002603684 384 EILHYQDEVAK------------Q------------QCELDNLSDTLRKR---------EDELMDLKDS---------YR 421  Florida lancelet
NP_001124350 271 NVNRLQSEVDR------------LtadlrdniadlnKTKETNKNE-IDKL---------KTELKELRQE---------LS 319  domestic silkworm
EHJ78659     191 SMKKLQAEVERlnndlmnsvtdlT------------KTKESNKKE-IEKL---------KTEVKELRQE---------LS 239  monarch butterfly
EEZ98911     451 EIKLLKEQLAR------------L----------------GNKSPTIDDL---------KEEIRELREE---------LS 484  red flour beetle
XP_007243359 377 EVSVLRDKLSA------------F------------ETEVAGLKKALSELshtanarapEHSLAEMGQLvlsrsrerlLS 432  Mexican tetra
Q6DIS8       550 Anlrhglclchekedpfl-------------------lyesdeakaqrqnadnLQGLQQYVERLREA------------- 597  western clawed...
XP_006006078 530 Npghthtydgeldklgnp------------------ltcesdeakmkrqsedaVHGLKKQLERLQSE------------- 578  coelacanth
XP_005045711 814 Smappagpfggelgeklrd----------------placesdeakmqrqsedsVNSLRRELERLQTE------------- 864  collared flyca...
XP_002936402 521 Slgqnpytielneklrdt------------------lacesdeakmkrqnedsVISLKKDIERLQLE------------- 569  western clawed...
XP_008760369 628 Scesdeakmrrqagvaaa------------------aslvsvdgevdaggeggTRALRREVGRLQAE------------- 676  Norway rat
XP_002603684 422 Qvkedlsnvraeldnkikeeq-------------lisqcdevkerrknkerdlIESLKVEVQRLRNE------------- 475  Florida lancelet
NP_001124350 320 Dvslsgyegiecgrtmrg-------------------iydvcktneyhwtssdSALEDAEVQRLNGEmpdacgdhcpans 380  domestic silkworm
EHJ78659     240 Dvslsgyegiecgrtmrg-------------------iydvcktneyhwtssdSALEDAEVQRLNGElpdscsepcpaga 300  monarch butterfly
EEZ98911     485 Dmslseygsvep-------------------------------grsqrisqedL-----EIECSCSS------------- 515  red flour beetle
XP_007243359 433 PlspsetptasllalpalpglpalpplpapaslpgadpllslqsddskaqrqeagdLRRQLELLQGE------------- 499  Mexican tetra
Q6DIS8       598 ----LTSERRRYQEQADSFEDERRIWQEEKEKVIRYQKQLQHNYIQMYQQNRELERDI 651  western clawed frog
XP_006006078 579 ----LRLERQQREQQVVGFEEERRTWQEEKDKVIKYQKQLQLNYVEMYQKNQLLEQQI 632  coelacanth
XP_005045711 865 ----LKLERQQREQQVMDFEEERRTWQEEKEKVIKYQKQLQLNYVEMYQKNQLLEHKV 918  collared flycatcher
XP_002936402 570 ----LTVEKQQRDQQVVDFEEERHTWQEEKEKVIKYQKQLQLNYVEMYQKNQQLEQRM 623  western clawed frog
XP_008760369 677 ----LAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRL 730  Norway rat
XP_002603684 476 ----LKTVHQRHDAQLMEFERERAIWQEEKEKVIHYQKQLQLNYVQMFRKTKNLEKEV 529  Florida lancelet
NP_001124350 381 ildrLKHELQNKETQ---FNNERRKWSEEKDKVLRYQKQLQMNYVQMFKRSRTLEAEV 435  domestic silkworm
EHJ78659     301 ivdrLKCEIQNKEQQ---FNNERRKWSDEKDKVLRYQKQLQMNYVQMFKRSRTLEAEI 355  monarch butterfly
EEZ98911     516 ----LAKLKQEIASKTKDFENERVVWAQEKEKVLRYQRQLQMNYVQMYRRTRALEAEV 569  red flour beetle
XP_007243359 500 ----LRLERQQRERQALSFAQERQTWQGEKDRVLKYQAQLQLSYVEMLQKNQALEERV 553  Mexican tetra
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