Conserved Protein Domain Family
Titin_Z
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pfam09042: Titin_Z (this model, PSSM-Id:286174 is obsolete and has been replaced by 462662)
Titin Z
The titin Z domain, that recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly.
Links
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Statistics
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PSSM-Id: 286174
Aligned: 28 rows
Threshold Bit Score: 34.9226
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KKF25251       433 AEGGKKAgAVATVMAAVDLARVRLP 457   large yellow croaker
XP_002808058   556 RQETEIT-AASMVVVATAKSTKLET 579   Rhesus monkey
ELK32702       559 RQTAETT-AASMVVLATAKATKLET 582   Myotis davidii
XP_005601669   553 RQKAE-T-AVSMMVVATAKSTKLEA 575   horse
XP_003501073   557 RQEAEKI-AASMVVLATAKSTKLET 580   Chinese hamster
XP_008760200   557 RQETETI-AAS-VVVATAKSTKLEA 579   Norway rat
ABG48500       377 QNTDEKSvAVATVVAAVDHARSRGP 401   zebrafish
XP_004942758   403 RRDSEKTaAVATVVAAVDQAMVREP 427   chicken
XP_005346680   416 KQEADKSaAVATVVAAVDMARVREP 440   prairie vole
XP_007669534   414 IQDSDKTaAVATVVAAVDLARVREP 438   platypus
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