Conserved Protein Domain Family
Det1
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pfam09737: Det1 (this model, PSSM-Id:286780 is obsolete and has been replaced by 462868)
De-etiolated protein 1 Det1
This is the C-terminal conserved 400 residues of Det1 proteins of approximately 550 amino acids. Det1 (de-etiolated-1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Mammalian Det1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 Associated 1), and a member of the UBE2E group of canonical ubiquitin conjugating enzymes and modulates Cul4A function.
Links
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Statistics
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PSSM-Id: 286780
Aligned: 32 rows
Threshold Bit Score: 452.066
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9VKM4       146 REFSVFLEEGRYAMLAAMT----VvrgaLPVDdyVRYPDLFDKVDAF-SYVFFLVDLKLGVVTDRLILPNDSIVIAHNHG 220 fruit fly
Q9ZNU6       121 KDFFLYMESNQFGLFATST----A----QIHDa-PPTGGAIQGVPSVeKITFHLLRLVDGAILDERVFHNDYVNLAHSIG 191 tomato
P48732       122 KDFFLYHQTRRFGLFATST----A----QIHDssSPSNDAVPGVPSIdKITFVLLRLDDGVVLDERVFLHDFVNLAHNMG 193 thale cress
ERN10827      76 KDFFLYMESNHFGVFATST----S----QILDa-PVTEGAIHGVPVIeKITLHLVRMEDGVIMDERTFRNDFVNLAHNSG 146 Amborella trich...
XP_002519399 158 KDFFLYVESSQFGVFATST----A----QFHDt-PAIGGAIQGVPSIeRITFHLLRLEDGEILDEKVFQNDFINLAHNMG 228 castor bean
XP_001778230 121 KDFFLSTENNLYGIFATST----A----PDTNa-AATNGAVPGVPCIeKITFLVVRFADGSITGRSVFKDDYIHLAHNAG 191 Physcomitrella ...
XP_003517544 121 KDFFLYMESNQFGLFATST----A----QIHDa-PAVGGAVHGVPSIeKITFHLLRLEDGEILDKKVFSNDFVNLTHNMG 191 soybean
XP_002976011 121 KDFFLTTENGVYGLFATST----G-----PDAdaASVQGAVPGVPSIeKIRILAVRLADGIITDDRIYHDDFIHLSHNMG 191 Selaginella moe...
XP_002014308 150 REFSVFLENGRYVLLAAMCilhgA----LATAdyISYPDLFDKLDAFs-YIFFVVDLVLGVVTDRLFLPQDSIVIGHNHG 224 Drosophila pers...
XP_001963225 148 REFSVFLENGRYVLLAAMSvlrnA----LPTMsyVLYPDLFDKLDAYs-YVFFVVDLEKDCVTHRLFLSQDSIVIAHNHG 222 Drosophila anan...

Q9VKM4       221 ISVFGSTVMMMSRLHQCVYVYWVN-DGKFHQQETIGPR--PRD--FIEKATtdfdnl----------------------- 272 fruit fly
Q9ZNU6       192 AFLYDDLLAIVSLRYQRIHILQIRdSGDLVDVRAIGEFcrEDDelFLNSNSqvlvnhvgng------------------f 253 tomato
P48732       194 VFLYDDLLAILSLRYQRIHLLQIRdSGHLVDARAIGYFcrEDDelFLNSSSqammsqdkskqqslsgskeddtgenglrh 273 thale cress
ERN10827     147 VFLYDDLLSIMSIRYQMIYILQIRaSGHLVDVRAIGQFcqEDDelFLNSHTqgfvpldkgkqeessi------cqdnssm 220 Amborella trich...
XP_002519399 229 VFLYDDLLAIVSLRYQTIHILQIReSGNLVDVRAIGAFcrEDDelFLNSSAqftvipdkskmhqpsr------nhiennv 302 castor bean
XP_001778230 192 VFLHDDLLAVLSIRFQRIHILQVRdGGLFLDVRTIGDFcrDDDelILNSQAqvlhnlsm--------------------- 250 Physcomitrella ...
XP_003517544 192 VFLYDDLLAIVSLRYQTIHILQIRdSGNLVDVRAIGEFcrEDDelFLNSNAqgmafsdknkqlqlpg------nhienhm 265 soybean
XP_002976011 192 VFMYEDLLAILSVRFQCVHILQIRdSGTFVDVRSVGDFcqEDDelLVSSQTqvtfprslsesnar----------sgreq 261 Selaginella moe...
XP_002014308 225 ISVHDSLVAIMSRLYQCIYIYEVVa-GRLVKRETIGPRprG----FIDEVSsdigvl----------------------- 276 Drosophila pers...
XP_001963225 223 ISVFGSTIAIMSRLHQCIYVYELV-EGRLVEQETIGPRprD----FIENASmdvgnl----------------------- 274 Drosophila anan...

Q9VKM4       273 ----dattvLPITHIKQRVLSFLYRKINDKS----G----NPTESQKSFYKNFEYIEHMIMERMHLVNNELLMLRYEer- 339 fruit fly
Q9ZNU6       254 hhslpqsetSFLSGIKQRLLSYIFRGIWNEAdq-----tmRVQCLKKKFYFHFQDYIDLIIWKVQFLDRHHLLIKFG--- 325 tomato
P48732       274 slsqpsgsnSFLSGVKQRLLSFIFREIWNEE----SdnvmRVQSLKKKFYFHFQDYVDLIIWKVQFLDRQHLLIKFG--- 346 thale cress
ERN10827     221 qldqptqggAFLSGIKQRLLSFIFRGIWNEEtdhsL----RVQRLKKRFYFHFQDYVDLVMWKVQFLDHHHLLIRFC--- 293 Amborella trich...
XP_002519399 303 pstqptsdnSFLSGIKQRLLSFIFRGIWNEDrhktT----RVQCLKKKFYFHFQDYVDLIMWKVQFLDRHHLLIKFG--- 375 castor bean
XP_001778230 251 --klpqaclQMLRGLKQRLLSFILQGIHNEVt--tP----AKAQQLKRFYYYFQDYMNLVMWKVQFLDRYHLLIKFG--- 319 Physcomitrella ...
XP_003517544 266 hqgqpnlgnSFLSGIKQRLLSFIFQGLWNEErddtL----RIQRLRKKFYFHFQDYVDLIIWKVQFLDRHHLLIKFG--- 338 soybean
XP_002976011 262 snsssetgpPVLGGIKQRLLSFIFRSILEHDddhvQ----RAQR-LKRFYYHFQHYTELVMWKVQFLDRYHLLIKFG--- 333 Selaginella moe...
XP_002014308 277 ----dantiLPITHIKQRVLSFLYRQIDANSs--------RSSQRYQDFYKNFDFLEHMIMEKMQLVNSDLILLRFEer- 343 Drosophila pers...
XP_001963225 275 ----dattvLPITHIKQRVLSFLYRQINVEAp--------GAKQKLQDFYKNFEFVEYMIMERMQLVNKELLLLRYEern 342 Drosophila anan...

Q9VKM4       340 pnGTDTMPMA-----TSPrR-LYVFYTITGEEVVGVYPEYSVNLLQILLQFNDYMSNDrsLQ-FGDAPSLP-MHFFlrh- 410 fruit fly
Q9ZNU6       326 --SVDGGVSRna--dIHP-S-FFAVYNMETTEIVAFYQNSADELYFLFELFSDHFHVSskSSlHMNFMSSHsNNIHaleq 399 tomato
P48732       347 --SVDGGVTRsa--dHHP-A-FFAVYNMETTDIVAFYQNSAEDLYQLFEQFSDHFTVSs-STpFMNFVTSHsNNVYaleq 419 thale cress
ERN10827     294 --SVDGGMSRnt--dQYR-A-FFAVYNMETTEILAFYQNSAEELFHLFEQYCDHFRAPsrSPlYMNFISSHsNNIHaleq 367 Amborella trich...
XP_002519399 376 --SVDGGVSRsa--dHHP-S-FFAVYNMDTTEIVAFYQNSADELYLLFEQFCDHFYATsrNSlHMNFISSHsNNIHafeq 449 castor bean
XP_001778230 320 --SVDGVILRnsevsHQN-S-FFAVYNMETTEILAFYPNSSEELLQLVEHYWDHFRVVpqSPlYMNFISSYsNNIFareq 395 Physcomitrella ...
XP_003517544 339 --SVDGGVSRna--dHHP-A-FVAVYNMDTTEIVSFYQNSADELYLLFEQFCDHFHATsrNSmYMNFISSHsNNIHaleq 412 soybean
XP_002976011 334 --SADGVISRscdvsQQL-A-FFVVYNFETTEILEFQQNSSLELLQLFENFADHFRSAqrYPvYMNYVTSFsNNVFvreq 409 Selaginella moe...
XP_002014308 344 pkDNDITPLLtlgeiPTP-RrFYVFYTILGEQVMGVYQDDSVELLQIILQFYDQMRNVrsLH-TGDAPSLPpqffl---- 417 Drosophila pers...
XP_001963225 343 rtDSDVTPLLp----SPR-R-LYVFYNIASEEVVGVYHDDSVDLLQIILQFYDQMSNVrsMQ-TGDAPSLPlhffl---- 411 Drosophila anan...

Q9VKM4       411 ------tfAdsN----ESVSVDRHTALRFNPSVPLSSQSLSSSPYLKFNEFRYDSRYVSPLEQPHRCCNDPIVFLD-RA- 478 fruit fly
Q9ZNU6       400 -----lrcT--K----NKATNFSQFVKKMMASLPCSCQSQSPSPYFDQSLFRFDEKLISAIDRHRQSTDHPIKFISrRQ- 467 tomato
P48732       420 -----lkyT--K----NKSNSFSQFVKKMLLSLPFSCQSQSPSPYFDQSLFRFDEKLISAADRHRQSSDNPIKFISrRQ- 487 thale cress
ERN10827     368 lrkqkdacL--K----NKATNFSQLVKKTLAFLPFHCQSQSPSPYFDQSLFRFDEKLISSTERHRPSTEHPIKFISkRH- 440 Amborella trich...
XP_002519399 450 -----lrtI--K----NKASSFSQFVKKMLASLPFSCQSLSPSPYFDQSLFRFDDKLISATDRHRPSTDHPIKFISrRQ- 517 castor bean
XP_001778230 396 lrkqkaacI--S----GKIGSYAQVIKRTLASLPHNSQSLSPSAYFDQYLFHFDEKLISSTDRHKPCAEHPIKFISrRR- 468 Physcomitrella ...
XP_003517544 413 l-----------rsikdKASSSAQFVKKMLASLPFSCQSQSPSPYFDQSLFRFDDKLISATDRHRQSTDHPIKFIL-RRy 480 soybean
XP_002976011 410 sreqkvacI--NtkasNKANSFAPIARRTLASLPVNSQSQSPSVYFDHSLFHFDEKLISATDRHKPSMEHPIKFLSrRR- 486 Selaginella moe...
XP_002014308 418 ----kqnfVdaN----KTINFMRQAALRFNPSVPVSTQSYSPSPYLKYNEFSYDDRLISPLERPKPCSAEPIVFRD-RT- 487 Drosophila pers...
XP_001963225 412 ----kqnfAdaS----ESIPFIRHAALRFNSSVPVSSQSLSPSPYLQFNEFSYDDRHISPFERPNPCSTEPIVFRD-RM- 481 Drosophila anan...

Q9VKM4       479 TDSIKFRLHATARRHLNPLAPRELCAFIWHPFDPLVLSIQKC--M--NSYVYHVHLY 531 fruit fly
Q9ZNU6       468 PNILKFKMKPGPEAGSTDGRTKKICSFLFHPILPLALSVQQT--LflQASVVNIHFR 522 tomato
P48732       488 PQTLKFKIKPGPECGTADGRSKKICSFLFHPHLPLAISIQQT--LfmPPSVVNIHFR 542 thale cress
ERN10827     441 PYSLKFKIKPGPEAGGVDGRSKRLSCFLFHPVLPFAISIQQT--L--QPSVINIHsv 493 Amborella trichopoda
XP_002519399 518 PCVLKFKIKPGPEAGSIDGRTKKVSSFLFHPFLPLALSIQQTlfM--QPS-VNIHFR 571 castor bean
XP_001778230 469 PNTLKFKINPGLELGSNDGHIKRVASFLFHPIFPFVISVQQSf-M--QTSIVNFHFR 522 Physcomitrella patens
XP_003517544 481 PYSLKFKIKPGPEAGSMDGRAKKISSFLFHPILPLALSVQQTlfL--QPSVVNIHFR 535 soybean
XP_002976011 487 PHILKFKINPGPENGANETRIKRVAAFVFHPIFPFAISIQQS--Fl-QASVVNFHFR 540 Selaginella moellendorffii
XP_002014308 488 TKLVKFRLSAKARRQNNPLAPRELCAFICHPFEPLILSIQKY--S--HIYAYNIHLY 540 Drosophila persimilis
XP_001963225 482 TKSVKFRLYAKARRPVSSLSPRELCAFIWHPFEPFVLSIQKC--M--NSYAYHVHLY 534 Drosophila ananassae
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