Conserved Protein Domain Family
Cast

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pfam10174: Cast (this model, PSSM-Id:287183 is obsolete and has been replaced by 431111)
RIM-binding protein of the cytomatrix active zone
This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Statistics
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PSSM-Id: 287183
Aligned: 9 rows
Threshold Bit Score: 802.561
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q811U3        155 QTQLKEVLRENDLLRKDVEV-KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQ--------H- 224  Norway rat
Q6PH08        151 QAQLKELQRENDLLRKELDI-KDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQ--------H- 220  house mouse
XP_006783392  156 QAQLREMQRENEMLRRELDL-KDSKLGSSTNSIKSFWSPELKKERIMRKEEAARTSILKEQMRVTHEENQlldarrtkH- 233  Neolamprologu...
XP_007564537  176 QTQLREVLRENELLRRELEG-KESKLSSSMNSIKTFWSPELKKERALRKDEATKMAVWKEQYRVVQEETQ--------H- 245  Amazon molly
XP_005478042  220 HSQLRDLQRENNNLRRELEGgRDGRTGPSMNSV-NFWSPDLKREKGVRREEGVRSSIVKDQYRTNQEDLQ--------Q- 289  Nile tilapia
XP_009296278  161 QAQLKEVLRENELLRKEIEV-KESKLSSSMSSIKSFWSPELKKERALRKDEASKISVWKEQYRAVQDETQ--------H- 230  zebrafish
XP_011600769  215 QAQLRNLQRENDNLRRELDR-GRS---CSTNNV-NFWSPEVKRDKGVRREEGVRS--LKDQYRSNHEDLQ--------Q- 278  torafugu
XP_007234528  151 QAQFRDMQRENELLRRELDL-KESKLGSSANSIKSFWSPELKKERVMRKEEAARTSVLKEQMRVTHEENQ--------Hm 221  Mexican tetra
XP_002128175   36 gdfilQLQQDLESLRREIDI-KESKLQSNMNSIKTFWSPELKKERALRKEERNQIVTLKEQLKVTQEENQ--------H- 105  vase tunicate
Q811U3        225 --------MQMTIQALQDELRIQRDLNQLFQQDs--SSRTGEPCVA--ELTEENFQRLHAEHERQAKELFLLRKTLEEME 292  Norway rat
Q6PH08        221 --------LQLTIQALQDELRTQRDLNHLLQQE---SGNRGAEHFTi-ELTEENFRRLQAEHDRQAKELFLLRKTLEEME 288  house mouse
XP_006783392  234 --------LQMTIQALQDELRTQRDLNHLLQQEs--GNRSGSEHFTtiELTEENFRRLQAEHDRQAKELFLLRKTLEEME 303  Neolamprologu...
XP_007564537  246 --------LQCTIQALQDELRIQRDLNQLFQSDyseSGRLGAQPIPpqEMTEENFLRLHSEFERQAKELFLLRKTVEEME 317  Amazon molly
XP_005478042  290 --------LPLTVQELQEELRAHREMNSRSQHHrqqGNSYRE-LHMdqDLTEENFFQLQSEHERQAKELSLLRKTMEEME 360  Nile tilapia
XP_009296278  231 --------LQTTVQALQAELRIQRDLNQLLQPP-------GEPLACepS----------EEQERQARELFLLRRTLEEME 285  zebrafish
XP_011600769  279 --------LPLTVQELQEELRAHREMNSRLQHQrqqGNSGSYRAPLdpS--EENFLRLQSDHERQAKELLLLRKTMEEME 348  torafugu
XP_007234528  222 ldarrtkhLQMTIQALQDELRTQRDLNHLLQQEs-sSRGSGAEHFTtiELTEENFRRLQAEHDRQAKELFLLRKTLEEME 300  Mexican tetra
XP_002128175  106 --------LHLTTQALQDELRAQRDLNQLLHEDfvtSPSDGGDKEStrIMQDN--------YDRLLRENELLQSTMEELE 169  vase tunicate
Q811U3        293 LRIETQKQTLNARDESIKKLLEMLQSKGLSAKAT----E----EDHERTRR----LAEAEMHVHHLESLLEQKEKENNML 360  Norway rat
Q6PH08        289 LRIETQKQTLNARDESIKKLLEMLQSKGLPSKSL----E----DDNERTRR----MAEAESQVSHLEVILDQKEKENIHL 356  house mouse
XP_006783392  304 LRIETQKQTLGARDESIKKLLEMLQSKGLPPGPG----R----ATEEEEQErarrIAEAEAQLGHLEVILDQKEKENIHL 375  Neolamprologu...
XP_007564537  318 LRIDTQKHTLTARDESIKKLLEMLQSKGLSSRAT----E----EDHERTRR----LADAEMTIHQLEGLLEQKDKEMLQL 385  Amazon molly
XP_005478042  361 MRIDSQKQTLGARDESIQRLLEMLQGQ--SQGQG----Q----GHWGRGQR----TGIITMAAQEAEAQL-----ENVHL 421  Nile tilapia
XP_009296278  286 LRMEAQRQTLVARDDSVKKLLEMLHSKGPSAKAS----E----EDHERTRR----LADAEMHAHHLENLLEQRDKELVAL 353  zebrafish
XP_011600769  349 TRIDSQKQTLDARDESIQRLLELLQGQG----------Q----GTWSRGHR----AGIITMAAQEAEAHQ-----ENMHV 405  torafugu
XP_007234528  301 LRIETQKQTLGARDESIKKLLEMLQSKGLPPVAGraseE----EEQDRARR----IAEAEAQLGHLEVILDQKEKENIHL 372  Mexican tetra
XP_002128175  170 SRIEAQRQTLGTRDESVRKLLEMLQCKGLPKSDD----EglnvEVDSMKAQ----IIGYQSRLGHMESLLHDKNIEVQQY 241  vase tunicate
Q811U3        361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK- 439  Norway rat
Q6PH08        357 REELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEVQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTK- 435  house mouse
XP_006783392  376 REELHRRNQLHQDPSKTKALQTIIEMKDTKIASLERNIRDLEDEIQMLKANGLLNTEDREEEIKQMEVYKNHSKFMKTK- 454  Neolamprologu...
XP_007564537  386 REELHRRYEAAPESTKTKALQTVIEMKDAKISSMERGMRELEEEVMMLKSNGALSSEEREEEIKQMEVYRSHSKFMKNK- 464  Amazon molly
XP_005478042  422 REELHRRNQLQADPAKTRALQTVIDMKDTKISSMERNIRDLEDEVQMLKTSGLLHSDERQDELKHVEVYKSHSKFMKTK- 500  Nile tilapia
XP_009296278  354 REELHRRLEGTPETTKTKALQTVIEMKDSQIGSLERGLRELEDQVMMLRSSSMLSCEERQEEAKQMEVYRNHTKFMKNK- 432  zebrafish
XP_011600769  406 REELQRRTQPQAEPAKTRALQAVIDMKDTKISSLERNIRDLEDEVQMLKTSGLLQPDDRQDELKQVEVYKSHSKFMKMK- 484  torafugu
XP_007234528  373 REELHRRNQLHQDPSKTKALQTIIE--------------------------------------------------MKVKr 402  Mexican tetra
XP_002128175  242 ------KNRCLDGNEETSTIHKVIDAKEAKISSLERMNREVELELESTKHEADIIMTQHREDVKQLEAVKSHSDFMKNK- 314  vase tunicate
Q811U3        440 IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQD 519  Norway rat
Q6PH08        436 IDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQD 515  house mouse
XP_006783392  455 IDQLKQELSKKESELLALQTKLETLNNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQD 534  Neolamprologu...
XP_007564537  465 MEQAKQELSRKDSELLALRTKLETLNNQFSDSKQHVDVLKESLTAKEQRAAILQTEVDALRLRLEEKESLLSKKSQQMSE 544  Amazon molly
XP_005478042  501 IEQLKQELNRKESEMQALQTKLETLTNQNSDCKQHIEVLKESLSAKEQRANTLQTEVDALRVRLEEKEQFLTKKTKQLQD 580  Nile tilapia
XP_009296278  433 MDQVKQDLSRKDTQLLGLQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETTLNKKSKQIQE 512  zebrafish
XP_011600769  485 IEQLKQELNKKESEMQALQTKLETLTNQNSDCKQHIDVLKESFSAKEQRANTLQTEVDALRVRLEEKEQFLTKKTKQLQD 564  torafugu
XP_007234528  403 IDQLKQELSKKESELLALQTKLETLNNQNSDCKQHIEVLKESLTAKEQRAAILQTEVNPHHTQFHTPNFI------DSVF 476  Mexican tetra
XP_002128175  315 VDQLKSDVQKKETEIVTLQTRLDTLNNQQSDNRQHIDVLKESLNAKDQRASVLQSEVDSLRNRLDEKQRILDEKQDYLLR 394  vase tunicate
Q811U3        520 MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALADKER 599  Norway rat
Q6PH08        516 LTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKER 595  house mouse
XP_006783392  535 LTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLGNLKDRVKSLQTDSSNTDTALATLEEALSEKER 614  Neolamprologu...
XP_007564537  545 LTEEKSTQQGEITDLKDMLDVKERKVNVLQKKIENLQDQLRDKEKQLSGLKDRVKSLQTDTSNTDTALGTLEEALAEKER 624  Amazon molly
XP_005478042  581 LTDEKSTLTGEIRDMKDMLDVKERKIIVLQKKIENLLEQLKDKDKQVAGLRERVQGLQTDSSNTDTALATLEEALSEKER 660  Nile tilapia
XP_009296278  513 MSEEKSTLNGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLRERVKSLQTDTSNTDTALTTLEDSLAEKER 592  zebrafish
XP_011600769  565 LTDEKSTLTGEIRDLKDMLDVKERKVNVLQKKIENLLEQLKDKDKQLAGLRERVQGFQTDSSNTDTALATLEEALSEKER 644  torafugu
XP_007234528  477 ITQNPAGQHH-------------------RSAIENLQEQLRDKDKQLGNLKDRVKSLQTDSTNTDTALATLEEALSEKER 537  Mexican tetra
XP_002128175  395 LQEDKSCDASELSHLRDTLDVKDRKILVLHKKIESLSEVVRERDGMLEEKKRALVALEEDSCTSDSALTTMEEALADKDK 474  vase tunicate
Q811U3        600 TIERLKEQRDRDEREKQEEIDTYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKK 679  Norway rat
Q6PH08        596 IIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKK 675  house mouse
XP_006783392  615 IIERLKDQREREDRERLEEVESYKKENKELKEKVNSLQIELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAIEQKK 694  Neolamprologu...
XP_007564537  625 IIERLKEQREKEEREKGDEMETSKKELKELREKVSLLQAELADRETSVLDLKEKASSLASSTLKKENRLKSLEINLEQKK 704  Amazon molly
XP_005478042  661 VIENLREQKDREDRVRLEELEQLRKENHELKDKLSVMQPQKQPQNQPGNPSP--SQNQRPDG------------EVKTKV 726  Nile tilapia
XP_009296278  593 IIERLKEQRDREEREKAEELDTSKKELKELKEKVSLLQGDLSDRETSLLDLKEHASSLASSGLKKDSKLKSLEIALEQRR 672  zebrafish
XP_011600769  645 VIENLREQKEREDRTRLEELDQMRKENQELKDKLTALQPPSASQSQAAN--PGVTQNQRPD-REMAAKADSIPAGSTT-- 719  torafugu
XP_007234528  538 IIERLKEQREREDRERMEELESYKKENKDLKEKVSTLQVELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAMEQKK 617  Mexican tetra
XP_002128175  475 IVEALQHEISLLRQQLRDESADLNQQLKNAEQQLDCSRRDVTERETSISELQEQATSLASSIVKKDSFIKQLEINIQKHT 554  vase tunicate
Q811U3        680 EECLKMESQL-K-------------KAHEATLE--ARASPEMSDRIQQLEREIARYKDESSKAQTEVDRLLEILKEVENE 743  Norway rat
Q6PH08        676 EECNKLEAQL-K-------------KAHNIEDD--SRMNPEFADRLKQLDKEASYYRDECGKAQAEVDRLLEILKEVENE 739  house mouse
XP_006783392  695 EECSKLETQL-QkqaeqlfshmntpKAHEVEQQsgSRGNPEYVDRVKLLEKEVSYYKDEANKAQTEVERLLDILREVETE 773  Neolamprologu...
XP_007564537  705 EECIKLENQL-K-------------KAQSAAAE--SQANAELTERISSLEQEVTRCREEAGKAQSEVERLLEILREMENE 768  Amazon molly
XP_005478042  727 DGPPAMSPT-----------------IQTTEEA--VKICPDITDRLRVLEQEVGRYREESRKSQAEVERLMGALKDAEMD 787  Nile tilapia
XP_009296278  673 EECSKLENQL-K-------------KAHSAAVN--AQANAEISERISSLEADVSRHREDSAKAQAEVDRLLDILRQMENE 736  zebrafish
XP_011600769  720 --------------------------TQNTEEA--TRKCADITDRLRLLEQEVARNREDSRKSKAEVERLMLALREAEME 771  torafugu
XP_007234528  618 EECSKLETQLqK-------------KAHEVEVVqgSRGNPDFLDRVKLLEKEVNFFKEESNKSQAEVERLLEILREVESE 684  Mexican tetra
XP_002128175  555 EDFNRLQNQH-K-------------KAQQQAMT--ETTKEEFNLKIRNLEIEVQSKVDEASRCQGDLDRLLGILKETENE 618  vase tunicate
Q811U3        744 KNDKDKKIAELES---LTSRQ-VKDQ-N-----------K-KvANL-K------------------------HKEQVE-- 779  Norway rat
Q6PH08        740 KNDKDKKIAELES---LTLRH-MKDQ-N-----------K-KvANL-K------------------------YNQQLE-- 775  house mouse
XP_006783392  774 KNDKDKKIAELES---LAPRQgGKDQvK-----------K-G-SNI-K------------------------LGLQGD-- 810  Neolamprologu...
XP_007564537  769 KNDKEKKIHELES---LASRQ-IKDQ-S-----------KkV-ANL-K------------------------HKEQLE-- 804  Amazon molly
XP_005478042  788 KSCKEKKISDLER---H-------GQ-I-----------K-S-PNIqK------------------------QTVPGE-- 817  Nile tilapia
XP_009296278  737 KNDKDRKISELES---VASRQ-MKEQ-SkksgkhkeppgK-G-RNV-N------------------------DGPQQEsl 784  zebrafish
XP_011600769  772 KLSKEKKIADLERpgqIKSPT-IQKQ-M-----------V-P-AEM-RkdpltdghphslsqqtrfdpqlplSASQEA-- 833  torafugu
XP_007234528  685 KNDKDKKIAELES---LAPRP-GKEQ-Nk----------K-G-PNI-K------------------------LGQPGE-- 720  Mexican tetra
XP_002128175  619 KHSKDEKISAMEK-------K-HKEQ-T-----------M----KI-K------------------------SLQTEMie 649  vase tunicate
Q811U3        780 ----------------------KKks----------------------------aQMLEEARr-------------rEDS 796  Norway rat
Q6PH08        776 ----------------------KKkn----------------------------aQLLEEVRr-------------rEDS 792  house mouse
XP_006783392  811 ----------------------KKgl----------------------------gQ-----Dp-------------rKDS 822  Neolamprologu...
XP_007564537  805 ----------------------KNrn----------------------------aQLMEDAKk-------------rEDN 821  Amazon molly
XP_005478042  818 ----------------------MRkdalidghphslsqlpllasqdamrdtaeriMELERALresmntsahrealwaQEE 875  Nile tilapia
XP_009296278  785 --------------------rqKAer----------------------------iEELEEALresvqitaeremvlaQEE 816  zebrafish
XP_011600769  834 ----------------------MRet----------------------------aERLTEMEk-------------aLRE 850  torafugu
XP_007234528  721 ----------------------Kkg-----------------------------sSILQDPRk---------------DN 734  Mexican tetra
XP_002128175  650 earrkgaaqdrdvakylsemqtKDer----------------------------vEELEEALresvsitaerevvlaGVE 701  vase tunicate
Q811U3        797 LSDSSQQ--------------------------------------------LQVEELLMAMEKVKQELESMKAKLSSTQQ 832  Norway rat
Q6PH08        793 MVDNSQH--------------------------------------------LQIEELMNALEKTRQELDATKARLASTQQ 828  house mouse
XP_006783392  823 SIDGGHH--------------------------------------------LKLEELMNTLERTRQELDATKQRLSSTQQ 858  Neolamprologu...
XP_007564537  822 LNESSQQikdslrqkeerieeleealresvqitaerevvlaqeeqarshaeKQVEDLLVAMEKVKQELEVMKAKLSSTQL 901  Amazon molly
XP_005478042  876 AARVQAQ--------------------------------------------RQLEELMGALEKTRQELDATKLRLSSTQQ 911  Nile tilapia
XP_009296278  817 AARNHQE--------------------------------------------KQMEELLGAMEKVKLELESMKAKMSSTQQ 852  zebrafish
XP_011600769  851 SMNTSAHrealwaqe----------------------------esarveaqRQLEELMGALEKTRQELDTTKLHLSSTQQ 902  torafugu
XP_007234528  735 PMDNP-----------------------------------------------KMEELMNVLEKTRQELDATKQRLTSTQQ 767  Mexican tetra
XP_002128175  702 EGRRVAE--------------------------------------------NQLAELVAEFTKTKQVLEETGMRVASMEV 737  vase tunicate
Q811U3        833 SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSS-KKKTQEEVAALKREKDRLVQQLKQQTQNR 911  Norway rat
Q6PH08        829 SLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASkKKKTQEEVMALKREKDRLVHQLKQQTQNR 908  house mouse
XP_006783392  859 SLQERDTHLTNMRQERRKQLEEILEMKQQALLAAISEKDANIALLELSASnKKKTQEEVLALKRERDKLMHQLKQHTQSR 938  Neolamprologu...
XP_007564537  902 SLAEKEGHLTALRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSkKKKTQEEVSALKREKDSLVHQLKQQTQNR 981  Amazon molly
XP_005478042  912 SLHERDGHLNSLRQERRKQLEEILEMKQQALLAAISEKDANIALLELSSSkRKKAQEEVMALKREKDRLMHQLKQQTQSR 991  Nile tilapia
XP_009296278  853 SLAEKEAHLTTLRAERRRHLEEVLEMKQEALLAAISEKDANIALLELSSSkKKKTQEEVAQLRREKDRLVQQLKQQTQNR 932  zebrafish
XP_011600769  903 SLHERDRHLNSLHQDRRKQLQEILEMKQQALLAAISEKDANIALLELSSSkRKKAQEEVMALKREKDRLMHQLKQQTQSR 982  torafugu
XP_007234528  768 SLTERDGHLTNLRQERRKQLEEILEMKQQALLAAISEKDANIALLELSSSnKKKTQEEVMSLKREKDRLMQQLKQQTQSR 847  Mexican tetra
XP_002128175  738 MVESKDRMLEKLRGERRKQMEEALEMKQEALLAAISEKDSNIALLELSQPrKKSNADEVCLLRREKDALVQQLKQQTQNR 817  vase tunicate
Q811U3        912 MKL 914  Norway rat
Q6PH08        909 MKL 911  house mouse
XP_006783392  939 MKL 941  Neolamprologus brichardi
XP_007564537  982 MKL 984  Amazon molly
XP_005478042  992 MKM 994  Nile tilapia
XP_009296278  933 MKL 935  zebrafish
XP_011600769  983 MKL 985  torafugu
XP_007234528  848 MKL 850  Mexican tetra
XP_002128175  818 LKL 820  vase tunicate
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