Conserved Protein Domain Family
Stk19
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pfam10494: Stk19 (this model, PSSM-Id:287466 is obsolete and has been replaced by 431315)
Serine-threonine protein kinase 19
This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP.
Links
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Statistics
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PSSM-Id: 287466
Aligned: 55 rows
Threshold Bit Score: 126.594
Created: 22-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4WG64        89 RDRMFEDIPA-RAGMNSTRIAEVLNLRR-S-LP--------PLASVAHVHTLM--D--APTKVEKEIVDLITAGRVRRLI 153 Aspergillus fum...
Q5XVE4        36 gavsedqclpledDLTFSDTSVALRMMR-AqFPridqasipPFILQSQLYSSVn----DRTQVDRELECLRREKVVRVFK 110 thale cress
Q0P4I9        40 aspypDFTEDpHGAVSYLCALFPRKLFN-DtLP--------PLFLKHQLYSLLq----DRTAVDRLLSSLQQKGEVCLVQ 106 western clawed ...
Q6C2M4        80 LDNMYEEIP-----IGKAYTAPTYEARQ-N-VP--------PLVKMTHVHAYS--Lr-EPTLVLRRVNDAVEAGLLRKVA 141 Yarrowia lipoly...
CCE44862     116 EEKVFQ-----IKGLSSTLKAELIRYRH-S-LPq-------GLVAITQLYAIF--HneGPTFVDKSLELNIRKGILRKFI 179 Candida parapsi...
XP_001525879 135 gntteEVIFQ-IKGLSLTSKAELVKFRL-S-FPs-------GIVTINQLYSIFsaQ--GNTFVDKQVELNVRQGLLRKFV 202 Lodderomyces el...
XP_002277335  22 esedydealsleqsLTFSDTLVALRIMR-AqFPqiekvsvqPFILRSQLYSSV--K--DRTQVDRELESLRRDKVLRIFK 96  wine grape
XP_006005728  32 kraMFQDVPDtKAALKYLASLFPRKLFNdS-LP--------PVVLKHQLYSIV--K--DKTTVDRQLNELKDQGEIRIFQ 98  coelacanth
BAG99456      34 vhttqiytssledtLTFSDTMIALQLMR-TqFPklekvvtePFILQSQLYSSV--K--DRTQVDRDLESLKKDKVLRVFK 108 Japanese rice
XP_002307653  30 etsstdqtlslvdsLTFSDTMVALRIMR-AqFPhidkvsiqPFILHSQLYSSV--K--DRTQVDRELESLRREKVLRVFK 104 black cottonwood

Q4WG64       154 VPGRGTDA---------------A----GLG-----------DCLVLTEDW----ERL----V----R---E-SSvLEAS 187 Aspergillus fum...
Q5XVE4       111 LNTGQDD-----------------------------------HAIIFLDDY----LNQ----VdrivK---R-MEeKKQS 143 thale cress
Q0P4I9       107 TGFDPDT-----------------------------------FMVVMTDDL----RRT----A----L---S-SSeGGSR 135 western clawed ...
Q6C2M4       142 VNNVDEG-----------------------------------VLLMEADKF----YKL----LdqsiQ---E-CKvANQK 174 Yarrowia lipoly...
CCE44862     180 ITNASPVI---------------SrshnKFQvnkvtygfediEVIAKVDYF----HKL----I----K---KvMSgLDDK 229 Candida parapsi...
XP_001525879 203 LNNASPVIlrsinrlqmrkvtygY----ENV-----------ELLVKTEDY----YKN----L----InivE-STdKENE 254 Lodderomyces el...
XP_002277335  97 LNTGQDD-----------------------------------HAIMFMDDYlnqiERV----I----K---R-MAaKKQD 129 wine grape
XP_006005728  99 LGFATDV-----------------------------------FGIVFTDEY----KNK----V----L---A-ATaGKEH 127 coelacanth
BAG99456     109 LNTGQDD-----------------------------------HAIMFMDDY----LKQmalaV----K---R-SRgKDQD 141 Japanese rice
XP_002307653 105 LNTGQDD-----------------------------------HAIMFLDDYltqvDRV----V----K---R-MEeKKQR 137 black cottonwood

Q4WG64       188 -----V--K---D----KFLQVLVQIGNTSAI------PASlL-------------SQ-SERMELLRAGFLVSSSSlvkg 233 Aspergillus fum...
Q5XVE4       144 -----D--LeifK----LFKMHVLDSKLEPSIghhellSLLsLgg---------kvKD-AHITLLINAGLLTRQ------ 196 thale cress
Q0P4I9       136 -----A--Tv-vR----KFLDCDLLLSPKISYgrdevmMKHrF-------------SD-GEITKLVRAGLLTVR------ 183 western clawed ...
Q6C2M4       175 ka---------lE----EFKILLLSHPSRVEFg---------F-------------DElPNASTLVKSGFLTMN------ 213 Yarrowia lipoly...
CCE44862     230 ssskqA--L---V----KFNELISLHPTEMFI------STLdF-------------TN-EEVSNLVQLGFITLTSN---- 276 Candida parapsi...
XP_001525879 255 -----K--L---RltmsKFLNLAKSSPLQMFI------STSlF-------------DD-YEVSMLIQMGYLTLTTN---- 300 Lodderomyces el...
XP_002277335 130 -----E--LavfE----WFKTHVITSKLEPSIehqelcSLLsFgg---------nvKD-EHISLLINAGLLTRQ------ 182 wine grape
XP_006005728 128 -----SvvT---Q----KFLETVLMSCSDISFnkekmlKEFlF-------------RD-KEITQLMNAGVITVR------ 175 coelacanth
BAG99456     142 -----G--T---Evf-gWFERYVIHLKLEVSI------DQRdLfslls---lggdvTD-KHITLLMNAGLLTRQ------ 194 Japanese rice
XP_002307653 138 -----N--L---Evf-eWFKTHVIDNKQDPSI------DHQeLvssmdiylngnqlHW-SHLELL--AGSLTRQ------ 191 black cottonwood

Q4WG64       234 stgvaslpglpcsapasasrsgsadqscdtpdnqyQ-SRFETTTLFLSLPNTGPYLRLLGAGRKHLLDLLNKSSSGEAPV 312 Aspergillus fum...
Q5XVE4       197 --------------------------------------LIDPDMYWFAIPSTGKLWKGLSQGRNELLSLIKRKRHKEMFL 238 thale cress
Q0P4I9       184 ----------------------------------------DAGSWWLAVPGAGRFITHFIKGRKALLSQIRRSRYKEVLL 223 western clawed ...
Q6C2M4       214 --------------------------------------PQEAQMYNVCVPNVGVFLKLGASARTWFINMLKKQSYQEMLE 255 Yarrowia lipoly...
CCE44862     277 -----------------------------------HfNEIE-HKYSISYPGCGTYLKLVNEGRTWLVKSLNRNKHKEALE 320 Candida parapsi...
XP_001525879 301 -----------------------------------F-SSSEEAQLEISYPGCGRFLRLINEGRMWLVGTLNRNTHKEMLE 344 Lodderomyces el...
XP_002277335 183 --------------------------------------LIDPNMYWFAIPNIGSLLKGLSQGRKELLSFLNRRRYKEMML 224 wine grape
XP_006005728 176 ----------------------------------------DAGSWWLAIPGAGRFVKYFIKGRKHVLGMIKKTKYKEVLQ 215 coelacanth
BAG99456     195 --------------------------------------LIDPNMYWFSIPSIGPVLKGLTQGRKEILSLLNRKKYKEMLL 236 Japanese rice
XP_002307653 192 --------------------------------------LIDPNMYWFAIPNIGSILKGLSQGRKELLSLINRQRYKEMML 233 black cottonwood

Q4WG64       313 YLLRDRWDG-AVETDKSFSVAKrmrgefagilpgktRKWKELYGMNFHWALEEALGAGLIEIFDTgSVGPAVRA 385 Aspergillus fumigatus
Q5XVE4       239 AELEKK--------------------------------RLRFSPLDVRFHVRDLIGSGHLKTVQT-TSGLIVRI 279 thale cress
Q0P4I9       224 TDLSTR-------------------------------KAPPNLRLGMEFHIHDIIGAGLVDCIPT-ASGTLLRI 265 western clawed frog
Q6C2M4       256 EQMEKKWSAn-------------------------sNRWKGFKGVSFEWILKDLYGGYHCECFST-PVGRGWKL 303 Yarrowia lipolytica
CCE44862     321 EELFRKWSGmNPEGDPKLNNFR-----------------KPFYGYDLHWVLADGLGSGIVEVFNT-PVGRGWRL 376 Candida parapsilosis
XP_001525879 345 DELFRKWMGvSLEGDLKLNNFK-----------------KPFYGYDLHWVLADAFGGGIVEVFNT-PVGRGWRL 400 Lodderomyces elongisp...
XP_002277335 225 APLE--------------------------------KKRLRLSPLDMRFHLRDLIGSGHVKTVHT-PTGLVVRV 265 wine grape
XP_006005728 216 SDLETR-------------------------------KMVSAVKLGIQYHVHDIIGAELVTCIPT-TSGTLLRL 257 coelacanth
BAG99456     237 SSLE--------------------------------KTRLRFSPLDVRFHIRDLIGSGHIKTVQT-PTGLLVRI 277 Japanese rice
XP_002307653 234 APLE--------------------------------KKHLRLSLLDMRFHLRDLIGSGHLKTVNT-PTGLLVRV 274 black cottonwood
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