Conserved Protein Domain Family
PACT_coil_coil

?
pfam10495: PACT_coil_coil (this model, PSSM-Id:287467 is obsolete and has been replaced by 463115)
Pericentrin-AKAP-450 domain of centrosomal targeting protein
This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly.
Statistics
?
PSSM-Id: 287467
Aligned: 100 rows
Threshold Bit Score: 55.2802
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q176E0       2849 KYLRSESHRKALVHQKRYLQIVLTTYEENEAKALQLLNAqnvpmgi---------------------------------- 2894 yellow fever ...
XP_008594583 1199 RWEREAAKRTDAAYAKKFIQLQLDISTACNKAQLRELEHirt-------------------------------------- 1240 Beauveria bas...
ENH68299     1086 RFQREASLRADAAYAKKFLQLQLDVANACNKAQLRELEDirtnllgn--------------------------------- 1132 Fusarium oxys...
XP_006666476 1211 RWEREAMMRTDAAYAKKFIQLQLDISSACNKAQLRELEHirtnllhs--------------------------------- 1257 Cordyceps mil...
EHK23274      744 RWEREAALRKDVSYAKKFVQLQLDVAMACNKAQVRELQKara-------------------------------------- 785  Trichoderma v...
XP_007912696 1249 RWEREVQLRADAAYAKRYLLLELDVRDACNKADLVKLDGimkqlgvkg-------------------------------- 1296 Togninia mini...
XP_007275863 1301 RWKREVSLRADAAYAKKFLQLELDVANACNKAQLRELEQircdllgsrqp------------------------------ 1350 Colletotrichu...
EHK43710       11 RWEREASLRSDAAYAKKFLQLQLNIADACNKAQLRELEHirtkvlqsr-------------------------------- 58   Trichoderma a...
XP_007820807 1164 RWEREASLRSDAAYAKKFIQLQLDVANACNKAQLRELEHirtnllhsk-------------------------------- 1211 Metarhizium a...
XP_007797533 1225 RWEREAKLRNDAAFAKRFLGLQLEVAEACNKADLRILRGihkqlgisspdsllsasrqkqqqersallygggggggggdn 1304 Eutypa lata U...
Q176E0       2895 ------qglslakPNADE--------NHPR-------RKSFRSVVTAIIAIERMKFIVRKW 2934 yellow fever mosquito
XP_008594583 1241 ----------kilHSRTP--------LPAPsflkqrnKPTLRTFLVLARFVARMRLSARKW 1283 Beauveria bassiana ARSEF 2860
ENH68299     1133 -----kkalslpsHTTAA--------TSNT-------KPTLKTFLVMARFIARARLSANNW 1173 Fusarium oxysporum f. sp. cubens...
XP_006666476 1258 ------rkplqllPSSSP--------EERQ-------KPTLRTFLVLARFVARMRLAARKW 1297 Cordyceps militaris CM01
EHK23274      786 ----------yvlQSRHPvvipelpsSTKS-------PTTLKAFLVMARFIARMRIAARNW 829  Trichoderma virens Gv29-8
XP_007912696 1297 -----rpassmpaARQIA--------AKKQ-------PITLKRVATAIRFVVRCQLSADAW 1337 Togninia minima UCRPA7
XP_007275863 1351 --lpptssalakkGTTGG--------AGPG-------RPTLKTVATMARFIARMRISAREW 1394 Colletotrichum gloeosporioides N...
EHK43710       59 ----kpltlpkppSFSSS--------GGSP-------SPKLKTFLIMARFIARTRIAARNW 100  Trichoderma atroviride IMI 206040
XP_007820807 1212 ----kplalpaapNGLAF--------GKVK-------PTSIRPFLTMARFIARMRIASRNW 1253 Metarhizium anisopliae ARSEF 23
XP_007797533 1305 hnkkdssnrkkkpAYHEV--------RAKA-------QHNLRVFATVLRAAARMRVDASRW 1350 Eutypa lata UCREL1
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap