pfam11548: Receptor_IA-2 (this model, PSSM-Id:288410 is obsolete and has been replaced by 463293)
Protein-tyrosine phosphatase receptor IA-2
IA-2 is a protein-tyrosine phosphatase receptor that upon exocytosis, the cytoplasmic domain is cleaved and moves to the nucleus where it enhances transcription of the insulin gene. The mature exodomain of IA-2 participates in adhesion to the extracellular matrix and is self-proteolyzed in vitro by reactive oxygen species which may be a new shedding mechanism.
Jiyao W et al.(2023). "The conserved domain database in 2023.",