Conserved Protein Domain Family
TAN

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pfam11640: TAN (this model, PSSM-Id:288488 is obsolete and has been replaced by 463317)
Telomere-length maintenance and DNA damage repair
ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.
Statistics
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PSSM-Id: 288488
Aligned: 107 rows
Threshold Bit Score: 85.0096
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7RZT9         12 KLIVTLNGKTITGRTSALKSLiSYFKGD-EtgsqaESH---------SQkl-------fdD-----------K------T 57   Neurospora cr...
XP_002822484   10 iCCRQLEHDRATERKKEVEKFkRLIRDP-Eti--kHLD---------RHs---------dS-----------K------Q 51   Sumatran oran...
XP_007232381   10 lCCRGLENEKATERKKEIDRFkRLLRDP-Et---vKELdrtsalkasRNn---------nQ-----------L------T 59   Mexican tetra
XP_002934974   10 lCCRQIETDKATERRKEIEKFrRLLRDS-Et---vQQL---------DQn---------sD-----------KrqakqlN 56   western clawe...
XP_006627926   10 mCCRGLESDKATERKKEADKFkRLIVSP-Et---vEAL---------DRasssraakgskQ-----------L------T 59   spotted gar
XP_008116369   10 TCCRQLDSDKATERKKEIEKFkRLLRDS-Eii--qQLD---------QNs---------dS-----------Khgk-qlN 56   green anole
XP_005025980   10 aCCRRLENERATERRNEIENFkRLLRDPgTv---lRLD---------QNsdsg----qgnQ-----------L------N 56   mallard
XP_002197770   10 vCCRRLENEKAVERRKEIENFkRLLRDS-Etv--lQLD---------RNs---------dS-----------K------Q 51   zebra finch
EKC30280       30 vyCRELSSEKATERKKSLEKLkNLLHKK-Sv---iNSL---------DYn---------sQhgrekvrernaL------T 81   Pacific oyster
EFX88021       14 ETSKCMGSEKITERRKSAETLdILLSNQ-Ny---iSIL---------DDn---------tD-----------Ash--gfT 58   common water ...
Q7RZT9         58 -----YHYVYEALFTCALTEKADYfsclksS---KSDSvRNSC-----VKR---LEGCAEALRLAVQHGAYKIKRKTATA 121  Neurospora cr...
XP_002822484   52 gkylnWDAVFRFLQKYIQKETECLri---aK---PNVS-ASTQ-----ASRqkkMQEISSLVKYFIKCANRRAPRLKCQE 119  Sumatran oran...
XP_007232381   60 -----WDAVFRFLKKYLQKETELLqs---gKa--NVSA-ITQA-----NRRk-kMQEISSLIKYFVRCANKRGPKLKCSD 122  Mexican tetra
XP_002934974   57 -----WDTVFRFLQKYVYKEMESIks---aK---PSVS-QTTQ-----STRrkkMQDISSVVKDFIRCANKRGPRLKCTE 119  western clawe...
XP_006627926   60 -----WDGVFGVLRRYVERETEALqt---gK---ANVS-ATTQ-----ANRhkkMQEVSSLLKFFIRCANKRGPRLKCTD 122  spotted gar
XP_008116369   57 -----WDTVFRFLQKYIHKETESArl---aK---PNVS-ASTQ-----ATRqkkMQETSSLAKNFIRCANKRAPRLKCQD 119  green anole
XP_005025980   57 -----WDAVFSVLKKYFEKEMENLrl---tKpnaSAST-QSAR-----QKR---MQEIGSLLKYFIRHANRRGPRLECQE 119  mallard
XP_002197770   52 akqlnWDAVFSVLQKYFQKELKNLql---tK---PNAS-ASTQ-----TARqkkIQEIGSLVKYFIRCANKRGPRLKCQE 119  zebra finch
EKC30280       82 -----WDDIIREVHSYVYLETQLLqk---gKepqSATA-RSSR-----EKK---KQEIGGVFKFVVKQAENRGPRLRASQ 144  Pacific oyster
EFX88021       59 -----WNNVFDAAIAYMSKEVEKFkq--deA---KGKA-LSQAqktlrENH---LKLSASSLLNVIVLAGERKPRLDVDI 124  common water ...
Q7RZT9        122 IADHITQTLLDSDdnFFEPLLKGYVK-V-L-SAFLNIQVNVENLAAFGGE 168  Neurospora crassa OR74A
XP_002822484  120 LLNYIMDTVKDSSn--gAIYGADYSN-IlL-KDILSVRKYWCEISQQQWL 165  Sumatran orangutan
XP_007232381  123 LLAHVVEVMQSSFs--CSAYGEDYSSmL-L-KNILSVRKYWCEITQQQWH 168  Mexican tetra
XP_002934974  120 LLLHVSNTVRDPt--TCSAYGADYSS-IlL-KDILSVRKYWCEITSQQWE 165  western clawed frog
XP_006627926  123 LLAHLVGVLRSSFs--CSAYGEDYSS-IlL-KDILSVRKYWCEVTQHQWa 168  spotted gar
XP_008116369  120 LLMYFTNTVNDPs--SYAIYGADCSS-IlL-KNILAVRKYWCEISSQQWS 165  green anole
XP_005025980  120 LMNYVFQIIKDPt--SCAAYGSDCSS-IlL-KDILSVRKYWCEIYQQQWp 165  mallard
XP_002197770  120 LLIYVMEIIRDPIs--CAAYGSDCSS-IlL-KDIISVRKYWCEISQQQWS 165  zebra finch
EKC30280      145 LIRQITEVL--RDefMLVAYGLDYSS-VlL-KNVLTVRKYCSEIGEKTWH 190  Pacific oyster
EFX88021      125 VLHHCLTALKDPF--MLEKFGRDHLT-A-LnREILSKRGYWSKLKPNSWL 170  common water flea
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