3UIN


Conserved Protein Domain Family
IR1-M
?
pfam12185: IR1-M (this model, PSSM-Id:288995 is obsolete and has been replaced by 463488)
Click on image for an interactive view with Cn3D
Nup358/RanBP2 E3 ligase domain
This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00638, pfam00641, pfam00160. There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.
Links
?
Statistics
?
PSSM-Id: 288995
Aligned: 24 rows
Threshold Bit Score: 65.4541
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3UIN_D          5 DVLIVYELTPTAEQKALATKLKLPPTFFCyknrpDYV-S---E-EEEDde-dfETA--VKKLNGKLYLDG 66   human
XP_006007981 1942 ECVIVWEKKPTPEEAAKAENLKLPPTFFC-----GVS-SdteD-DKYNqe-dfETE--VRKVKESQDNQG 2001 coelacanth
XP_011966544 2556 ECVIVWEKKPTVEEKAKADTLKLPPTFFC-----GVC-Sd-tDeDNGNae-dfQSE--LQKVQEAQKSQD 2615 mouflon
XP_008105263 2519 ECVLVWEKKPTPEEKAKAEILKLPPTFLC-----GIS-Sd-tDeDNENle-dfQTE--LRKVQEAKEAQv 2578 green anole
XP_004555650 2501 DCQVVWEKKPTPEEEKKAKSLQLPPTFFC-----GLStTd-sDpDQDKpe-dfETE--VRKVHEVLVAQl 2561 zebra mbuna
ETE71578     2301 EIIVVWEKKPTPKEKAKAETLKFPPTFLC-----GIN-Sd-tDeDNDNle-dfETE--LRKTQETKESQa 2360 king cobra
XP_011609741 1935 DCQVVWEKKPTAEEEQRAKSFQLPPTFFC-----GLS-Tt-dG-DTDDka-dfETE--VRKAQQELlirg 1993 torafugu
XP_007660816  375 ECVIVWEKKPTPEEKARAETLQLPPTFFC-----GVG-Sd-tD-DDDDpledfQTE--FRKAQEAEKPQD 434  platypus
XP_005037560 2471 ECAATWEKKPAPEEKDETKALQAPSTSLC-----GVS-Td-tE--GDSle-dvKSEakIQEMKEnevass 2530 collared flycatcher
XP_005807740 2398 DCQFVWEKKPTPEEEERAKSLQLPPTFFC-----GLSaTd-sEpDSEEpe-dfETE--LRKAQQDLVAQl 2458 southern platyfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap