Conserved Protein Domain Family
Condensin2nSMC
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pfam12422: Condensin2nSMC (this model, PSSM-Id:289207 is obsolete and has been replaced by 463573)
Condensin II non structural maintenance of chromosomes subunit
This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.
Links
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Statistics
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PSSM-Id: 289207
Aligned: 46 rows
Threshold Bit Score: 118.819
Created: 22-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6AV41        203 RCFVSPLFLKAEEGRKLLSLV-LG-VSEGLAREGLELIRAQVgmPGVKRAALVAYGEVVFRAWKDG-G----W------- 268  Japanese rice
Q20818         58 CIFFAPALLICPEGIKLSAEI-LPkIG---VGNGLILLEKLIlkFNLTDTECQRYGEVFVTAWRNAyQ----Ean---fd 126  Caenorhabditi...
XP_003114216   66 MMFFSPALTICPEGVKLVAEV-FV---KIGISNGLTLLEKNItkFDITDAECQRYGEVFKTAWLDAyQ----Das---fd 134  Caenorhabditi...
XP_001945402  210 tlmkCPLFLETETGKLAIADI-FT-CSQQLFLKFHQTVRQNI--PKANRSEAEAYGEIYFMAWINSnS----T------- 274  pea aphid
XP_002780112  157 KCICGRIFHRNDHGIAFVASV-LT-MHPAFIVDAFAAIKLFI--PQLPSSVLLGLSKALYRGWKESsG----A------- 221  Perkinsus mar...
XP_002431793   74 KVVESTAFVESEHGQKFIAWS-LL-LSSKLMLDIHKTIMLEL--SLCNKKKAGWYGKIYVIAWHNAvD----D------- 138  human body louse
XP_002636711   58 MMFFSTALTACPEGVKLVAAIlFK-IG---VANGMTLVEKNMtkYDMTDAECQRYGQVFTTAWLDAfQegefD------- 126  Caenorhabditi...
XP_001327152   58 dTIHCPNYYKTEKAKKFVASI-VH-VVFFKLPEICERFKSIL--RNEKTEQAEQFGELCVTVWSKCdV----T------- 122  Trichomonas v...
EGT38869       58 MMYCSPALMACKEGIKLLALI----LDKIGVRNGLTLLEKQIlkSDLTDTDCQRYGDVFATTWLNAhS----Dan---fd 126  Caenorhabditi...
EJD74302      101 RAVYEPYFITSLEGKKLAAHF----ISKIGVDKFWMLVKKVVtsEKTSKTQCANYGEVLLLAWKNAmK----Dgahrlqh 172  eye worm

Q6AV41        269 VRGEVGEAFLQGMLEGAVHA---------------RS-----KELA----KAARKLLSAFV-E--Q-R-M-VAGVEKLIF 318  Japanese rice
Q20818        127 LTEELETDVISVMCQHALYA---------------H------RPTC----TKFQNVIAAFA-H--AkK-L-DKSVDEMVT 176  Caenorhabditi...
XP_003114216  135 LTEEIETDVIRIICQYALYG---------------Q------KPFA----AKFRKVLSAFV-Sg-K-K-K-DVNFAEMIT 184  Caenorhabditi...
XP_001945402  275 IREVIEEQMF-DFISKTLTL---------------RR-----TGLAfyayRNALILLQSMQ-N--H-R-K-HLMFSKVIT 327  pea aphid
XP_002780112  222 MKRHIE-QAIQAWMDYSLKVdpvlakkvigdlllhHR-----DYMN----NKIRILLSEFH-R--KdR-R-PTELENLLV 286  Perkinsus mar...
XP_002431793  139 VKSALEKSCLQHLMEAFFKE---------------HRtslelSKCG----KNILTVLDVLH-SerK-K-K-NPEFVTMIT 195  human body louse
XP_002636711  127 LAEEMENDIIRVICQNALYA---------------Q------KPLG----SKFRKMLVPFAtS--K-K-Q-EVSVDEMIS 176  Caenorhabditi...
XP_001327152  123 ERSTFQVQLLKPIAECAILA---------------ET-----PQFS----KNCRAFLEKFG-V--K-RsR-RKELWTALT 173  Trichomonas v...
EGT38869      127 LTEELETDVYHVFFQHALFG---------------Q------KPLC----AKFQKVLSAFA-A--Q-R-KeNPDFAIMIS 176  Caenorhabditi...
EJD74302      173 RLERIFMDVVYYALQHLRCN------------------------------KKFMAMLESF--G--K-A-R-NKQVDAMIY 215  eye worm

Q6AV41        319 QLAEPVLFRSLQVANSNVRHNSLHLLLD-LFPLE 351  Japanese rice
Q20818        177 RLLNGCLYRALDAPNYIVQSSAAEVFFN-FYPLI 209  Caenorhabditis elegans
XP_003114216  185 RILNGCLYRAMDATNYIVSSSAVELFFM-FFPLI 217  Caenorhabditis remanei
XP_001945402  328 KLYAPVIWRQLTSEFSVVRCNATDILAR-AYPLE 360  pea aphid
XP_002780112  287 ELYQPILWKQLTVTNWKIRLNAIATLGD-AFPIC 319  Perkinsus marinus ATCC 50983
XP_002431793  196 EAYQPILWKYLQSGFNMHRCNAADIFYK-AFPLQ 228  human body louse
XP_002636711  177 RILEGCLWRALESSNYIVQSAASEVFFM-FFPLt 209  Caenorhabditis briggsae
XP_001327152  174 HIYEPIVFRYLHAANPLVRDNSLSLFTScAFPIE 207  Trichomonas vaginalis G3
EGT38869      177 GMLNGCIYRALDSKNSAVQTSGMEVFFM-FFPFV 209  Caenorhabditis brenneri
EJD74302      216 RTFEPNLWRCLKAANETVRCNACCLFLP-FYPFV 248  eye worm
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