Conserved Protein Domain Family
RasGEF_N_2
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pfam14663: RasGEF_N_2 (this model, PSSM-Id:291335 is obsolete and has been replaced by 464245)
Rapamycin-insensitive companion of mTOR RasGEF_N domain
Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.
Links
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Statistics
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PSSM-Id: 291335
Aligned: 82 rows
Threshold Bit Score: 47.593
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6C3B5        789 SPHWAISLLVGQL-----YDPDVEVCKLAVQLLQEYCSVT-ENVPHVVKCRP--AL---------DHL-GA--VGAPLLL 848  Yarrowia lipo...
XP_001326162  577 FAANPCSLKLNRC-----LALFCEVIESQEDCLKAASVDQ-QMHQV---------------------L-KK--ANRRIYS 626  Trichomonas v...
CBY15526      394 KDKW-LYLQTLSL-----VRQSPKQSDTALVAFQQF-----VRIPKIANy----AL---------QELgMImeFDLCLRQ 449  Oikopleura di...
XP_004179832 1078 LINYIMEMLTRQL-----YDLNPRVVALADQALYENAISEtEPENLISWLRT--SL---------SQMv---fIRSPILF 1138 Tetrapisispor...
ERG82696      840 FAEWGMSLLLAQL-----SDHSAKVVRHAIRLLHRWMPFYpESISLLKN-----VR---------LDAlGD--AGIMLKT 898  pig roundworm
XP_001891752  107 FSVWGIKLLLGQL-----ADPSAKVVRHALRLLHRWIPHYlESVYLIKD-----IC---------FDIfGD--AGILLKT 165  Brugia malayi
KKA77642      924 FADWGVRMMIGQI-----GDASVKVVRHAVRLLHTWLPLHpSSLPLLRA-----VP---------LHTlGD--AGVLLRV 982  Pristionchus ...
EGT36095       60 FSDWGIQLMLRQL-----ADESSKVVRHTIRILSRWLPEHpSRNLRKCE----------------WSVfGE--AGDLLKA 116  Caenorhabditi...
CAP23797      103 FSDWGIQLMLRQL-----ADESSKVVRHTLRILNRWLPEHpSRNLRKVE----------------WSLfGE--AGDLLKA 159  Caenorhabditi...
XP_001322643  103 afvnliiPYFKQLvstfkQDQINQRISPILQLLYEVVQDDpKATEYCANDKEvhSIlckygpigySYI------------ 170  Trichomonas v...

Q6C3B5        849 RFLCTSSGFQYL---QKM---D-FVALEMDSWFHGQNEAYVGRIEYYLEQ 891  Yarrowia lipolytica
XP_001326162  627 MLLSQKDSLSFV---N--------LEEEIDWWIEKGNKEYVEIYDEAISC 665  Trichomonas vaginalis G3
CBY15526      450 KILCVLVENEFIaqkVEEfggEtDLDFMLDSWMTTGQYEFSKEIEGRLKV 499  Oikopleura dioica
XP_004179832 1139 ELLSTSYGFQLL---DEV---D-FIESERISWIKRKNEEYVNIIEDFLNG 1181 Tetrapisispora blattae CBS 6284
ERG82696      899 HLFANEDYVG-----SNP---N-DVQVAFNLWRKEFNARYVEVIDEDLKV 939  pig roundworm
XP_001891752  166 YLFSNESYVK-----DNS---R-DVLATLDYWKRKFNMRYVEIVDEDVRV 206  Brugia malayi
KKA77642      983 HLFSCETETR-----KNM---S-AAREVVDFWMMKFNARYAATVEEEMRM 1023 Pristionchus pacificus
EGT36095      117 HVYALEFECA-----SDE---D-EVRDVIRFWMTDFNKKYLQIIDEEMKE 157  Caenorhabditis brenneri
CAP23797      160 HIFAMESECA-----NDE---N-EVRDVTRFWMKEFNKTYLNIIDEAMKE 200  Caenorhabditis briggsae
XP_001322643  171 --FSTPTALSNC-----------TVSDVVDWWMEDGNNDYFLAFDKAVEQ 207  Trichomonas vaginalis G3
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