Conserved Protein Domain Family
TMEM173

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pfam15009: TMEM173 (this model, PSSM-Id:291670 is obsolete and has been replaced by 464441)
Transmembrane protein 173
Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA.
Statistics
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PSSM-Id: 291670
Aligned: 29 rows
Threshold Bit Score: 272.974
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2KI99        44 LKWLVLHLASQQMGLLIKGICSLAEE-L-C-HVHSRY-H-G-SYWRAVRACLCSSMRCGALLLLSCYFYCsLPN------ 111 cattle
XP_002061566   6 IDTVVRIVITISLADLLQRVFLSAYEyI-W-NPRFYL-PdE-RFWTILRRTHTYSNKHVYLMLAFGCLGLaRFG------ 75  Drosophila will...
XP_001627385  57 SFTFSLAYLAFLVGELLRRCCLFAEE-Y-R-HIETRY-N-G-SLKKAIQTTFSFGHNNVLFVASLLFFVVfVASndpngs 130 starlet sea ane...
XP_011169646  46 TFVTSVFVEAFLICDLILRLCQTVIS-I-T-DVDQQS-R-E-SFWSMAKDYFTLNTASVTIFVISTLLCFcLSItirtcp 119 red fire ant
XP_002033149   6 IDTSVRIVATVFLADLLRRLYHCVIE-YgS-NGRYYL-P-EdRLWVILRRSCTYNNRSIYLIVGFVLVAFfRIS------ 75  Drosophila sech...
XP_001959984   6 aDVSIRVVATVFLADFLQRLFRCVVEyI-R-YSRYYL-P-EdRLWTILRRGCTYESKHIYLAMAFVIAGLsRIS------ 75  Drosophila anan...
XP_011066563  47 TFVASVFLVIFLLCDVTLRLCQTLIS-F-TtNVNQHS-E-E-SFWSVAKYHFSLNTLSATIIIIAALLFLgLSItirgcp 121 Panamanian leaf...
XP_011262840  23 CLTTSVFLVIFLLCDVMLHLCQTVIS-L-T-NMDPRS-R-Q-SFSSIISYYFILNIASAVVVLIGVFLFLiTSTtivrec 96  Florida carpent...
XP_001986375   6 IDTCVRILIVIFVADFMQRLSYALAE-Y-FlYGNHYLlE-E-RLLTILRRAFTYNSKTICLTFGIMFLGFaRFG------ 75  Drosophila grim...
XP_002005921   5 LDYAVRICIVIFVADLLQRLFFVFKEyL-C-HRIYYL-P-EdRLTTIIKRAYTYNIKTVYLALLVIFTGLtRFG------ 74  Drosophila moja...
Q2KI99       112 ------------------MAD-----LPF-TWMLALLGl--SQ--A-LNI--L---LGLQGLAPAEVSAIcekRNFNVAH 157 cattle
XP_002061566  76 ------------------VTGn---lKPI-LPSAMYLAc--MP--L-YWL--F---NDLGESTLSYANWVrdtHGLDYAS 123 Drosophila will...
XP_001627385 131 ssviqgnstaephtemrqTSG-----WQG-LWGQFIISallTP--L-VVH--L---LGLRELSKVEESQLnekENKNVAD 196 starlet sea ane...
XP_011169646 120 -------------lnyvwDFG-----PEV-GLSMMIFSf--CL--L-TRI--Cn-lADWEKRSLSDLSVM---KGLDYGT 169 red fire ant
XP_002033149  76 ------------------VTG-----NYRdVVPTTLFLv--HM--P-LYW--IwsfSDMDHSTLSYSHWIrdsHGLDYAA 125 Drosophila sech...
XP_001959984  76 ------------------VTG-----DFT-VVIPTALYl--AQipL-YWL--F---FDLSQSTLTYSHWIrenHGLDYAA 123 Drosophila anan...
XP_011066563 122 -------------lryawDFG-----PYM-CVPLMIFSf--CL--VrMSN--L---AEWETGSLSDLNIM---KGLDYGT 170 Panamanian leaf...
XP_011262840  97 ------------plshvwDFG-----PDV-YVPSMIFS---FY--L-LKItdL---AKRERGPLLDLDIM---KGLDYGT 146 Florida carpent...
XP_001986375  76 ------------------RTGnlnqlLPS-CSDFAYMPl--YW--I-Y-I--Y---AQMSQSSLSYAHWIrdaHGLDYAA 125 Drosophila grim...
XP_002005921  75 ------------------RTNnlallLPR-GEPLLLIPl--YW--I-FTY------VQLSHSSLSYAHWIrdsHGLDYAA 124 Drosophila moja...
Q2KI99       158 GLAWSYYIGYLRLILP--------G-----LPARIQIYNQFHNNtlqGAGSHRLHILFPLDCGVPDDL--NVA-D-P--N 218 cattle
XP_002061566 124 GMASSYFHGYLNLALP--------DrsddgLQHRMRRYEDSHNV---TFGVHRLIILIPDEMWVGGRI--N---S-D--L 184 Drosophila will...
XP_001627385 197 GLAWSYYFGYLKFVLP--------E-----LEKQIEKTSKFRSK---EKFVKKMFILIPSNCFWDDKIpgSDY-D-PqnR 258 starlet sea ane...
XP_011169646 170 GMAYSFYYGYLRLILPstet-grkG-----IIEKIETFEANHNI---TFPVHKLFLLIPSSGYIPPDL--KEA-SyQ--W 235 red fire ant
XP_002033149 126 GMASNYFHGYLKLSLP--------ErkddgLKQRMEMYEDKNNV---TFGIKRLVILIPDEMFVNGVL--E---S-H--L 186 Drosophila sech...
XP_001959984 124 GMASNYFHGYLKLALP--------DtkddgLKHRMAVYEAKNNV---TFGVDRLIILCPDEMFVEKKL--ENN-S-T--L 186 Drosophila anan...
XP_011066563 171 GMAYNFYYGYLRLTLPsset-gkkG-----IIEKIENFEDYHNV---TFPVHKLFLLIPSSGYIPPDL--KEA-ScQ--W 236 Panamanian leaf...
XP_011262840 147 GMAYSFYYGYLQLILPnrgttdskS-----IIEKIENFEDKHEV---TFPVHKLFILIPSSGYISPHL--KEMsD-Q--W 213 Florida carpent...
XP_001986375 126 GMASNYFHGYLKLSLParn---geG-----LQQRMTDYEDSQNV---KFGLRRLIILVPDEMFVKGLI--D---S-P--L 186 Drosophila grim...
XP_002005921 125 GMASSYFHGYLKLSLP--------ErendgLQKRMEKYEDMQNV---KFGIKRLIILIPDEMFVNRVI--Q---S-E--W 185 Drosophila moja...
Q2KI99       219 IRFLHELPQQSADRAGIKGRVYTNSIYEL----LENGQRAGVCVLEYATPLQTLFAMSQDGRA--G--FSREDRLEQAKL 290 cattle
XP_002061566 185 LEPAQPLETININRAGVKGRPYKIAVYRLn---RKINGKYYYFALEGATPMLSFFESIQSNLS--AtwYMRELKREIWLK 259 Drosophila will...
XP_001627385 259 ITFEGNTEPLEKTRGGVFLRHYKHSVYEI----KDGENEPWFCIMEYATPLLTLYDMSVAQPG--E--LSREERDAQVVV 330 starlet sea ane...
XP_011169646 236 MESTSNLEEEERNRAGNIGRIYLNSAYKIyldgRNSGNDPVYAVVEGASPLLTYHEVLQHNHP--EssVYKRYKSKIIER 313 red fire ant
XP_002033149 187 LDKAEPLETQFINRAGVY-RPFKHAVYRMn---KKVNGRTYYFAIEGATPLISFFDAIYSNLS--AtwQMQELKREIWLK 260 Drosophila sech...
XP_001959984 187 LDKAEPLETKYLHRAGVH-RPFKHDVYRLn---KKIDGKTYYFAMEGATPMLSFFDAMESNLS--AtwQMKELKREIWLK 260 Drosophila anan...
XP_011066563 237 MENIHELEEEKRNRAGNIGRTYRNNAYKIypggRKLGNKPIYIVVEGATPLLTYYEVQKHNHPesA--IYKQYKSKIIEK 314 Panamanian leaf...
XP_011262840 214 MEIAGELEEEKRDRAGLRGKTYHNNVYKIypngRNSGASPIYVVAEGATTLLTFYEVQQHSHP--EsiVYKQYKNEITMM 291 Florida carpent...
XP_001986375 187 FEKAKPLETHFINRAGVN-RPFKHDVYRLn---RKINNTSYYFAIEGATPMLSFFDAMHHQLS--AtwQMQEMKREIWLK 260 Drosophila grim...
XP_002005921 186 LDKAEPLETQFINRAGVN-RPFKHAVYRLn---KQINGTTYYFAMEGATPMLTFFESMHFQLS--AtwQMQEMKREIWLK 259 Drosophila moja...
Q2KI99       291 FCRTLEDILANAPESQNNCRLIVYQEpAEG--SSFSLSQEILQHLRQEE 337 cattle
XP_002061566 260 FSAHLKNLLTTWPETRGKVELLMYNS-LDDngNAIDVGELVIAQMEKWN 307 Drosophila willistoni
XP_001627385 331 FLRKLQDILEGDRACQGKYELVTFSP-DR------DLADVMLRKLKDSE 372 starlet sea anemone
XP_011169646 314 FYTKLLETLQSNPETRDLCELIYYND-YDAngDKVNVAKIILERISKIK 361 red fire ant
XP_002033149 261 FYKHLRELITTWPETRDLIELIIYNS-HDSkgNLVDVGELLVANMQNKT 308 Drosophila sechellia
XP_001959984 261 FCKHLKHLIETWPETRNEVDLLVYNA-HDQkgKLVDIGELLIAHLKNKT 308 Drosophila ananassae
XP_011066563 315 FYTKLQEILQSNPETRDLCELIYYDD-FDAqgNKINVATILLERISKIT 362 Panamanian leafcutter ant
XP_011262840 292 FYKKLAEILESEPTTKNLCELIYYND-YDSkgTRVNVAKVILQRISEIT 339 Florida carpenter ant
XP_001986375 261 FCKHLKGLLSTWPETRNEVELIFYSA-HNSngEHVDEAEVIINHVFKdk 308 Drosophila grimshawi
XP_002005921 260 FCKHLQELLNNWPETRREVQLIIYNS-HKQngELQDVGDVLISHVlthi 307 Drosophila mojavensis
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