Conserved Protein Domain Family
Spem1
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pfam15670: Spem1 (this model, PSSM-Id:292298 is obsolete and has been replaced by 464793)
Spermatid maturation protein 1
Spem1 is a family of mammalian proteins. Proteins are exclusively expressed in the cytoplasm of the last three steps of spermiogenesis in the mouse testis, and male mice deficient in Spem1 are completely infertile because of deformed sperm.
Links
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Statistics
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PSSM-Id: 292298
Aligned: 14 rows
Threshold Bit Score: 173.024
Created: 1-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0P670         1 MENQLWHNTVRCCNQYQESPHDAEDILLLLLGLIVLVNIGINVATMMWHGLQNALDKMIDWATQKNEI-QASESPPSGPP 79  human
Q68FV4         1 MENQLWQSTLGCCSQYQESPQDAENILFLLLGLIILVNISINVTTVIWHGLQNAIDKMFSRMHQKTAEvQVTECPPKEPQ 80  Norway rat
XP_002718851   1 MENQLWHDNLGCYSECQASPQDAEEILFVLLGLIILVNISINVTTAMWQGLQNILDRMISCIIPKDEV-QPSESPPKDPP 79  rabbit
XP_003791318   1 MENQLWHNSVGCCSQYQESPQDAEDILFLLLGLIILVNIGINMATVMWHGLQNALDKMMDCTNQKKDI-QAYESSPKSLP 79  small-eared galago
XP_003416943   1 MEDQLWYDTLGCCNQYQESPQDTEDFLLLLLGLIILVNIGINMATVMWHRFQNALDKMICWINQKNDAfQACQNSPRDPC 80  African savanna...
XP_003483151   1 MENQLWHDHLGCCHQYQESTQNAEDLLLLLLGLVVLVNIGINMATVMWQGLQNVLDKIAHWTNDKNEVlQACERSPKYPP 80  pig
XP_004887112   1 MENQLWHDTLGFCSQYQERPQDAEDILFLLLGLIILVNISINMATVMWNGLQNALDKMIYWINQKNEV-QASECSSKYPP 79  naked mole-rat
XP_004760363   1 MENQLWYDNVGCCNQYQEHPQDPEDVLLLLVGLVILVNIAINVVTMMWHGLQNVLDKMISWTNQKNETsQPCESPTKDPP 80  domestic ferret
XP_003466222   1 MENQPWRDTLGCCSQHQENPQDPEDILFLLLGLIILVNISINMATVMWHGLQNALDKTIYWINQKSEV-WASDCSAKDPP 79  domestic guinea...
XP_849713      1 MENQLWYDNVGCCNQHQEHLQDPEDLLLLLLGLIVLVNIGINVVTVMWHGLQNGLEKVICWINRKs---GACESSHKESS 77  dog

Q0P670        80 -DKAQDVHIHCILDPVQVKMSRPTQYSSFSCHHFSNHHSSSllrcvRRRR---------------RRHRR---------- 133 human
Q68FV4        81 pANVQDVHIHCVLDPVQVKMAQPTQCSSSSTHYFRKHSNDR-----RSRR---------------RYCYP---------- 130 Norway rat
XP_002718851  80 -AKPQDVHIHCTLDPVKVKMTQPIHYSSSSCHRFHNRRNSR-----NRTN---------------SRGRR---------- 128 rabbit
XP_003791318  80 -AKAKDMQIHCILDPVQVKMTRPTQYSSSSCHHPCKHRHSR-----RRSR---------------SRSRCgsrsrsrihh 138 small-eared galago
XP_003416943  81 qAPARDIHIHCTLDPVEVKMAQSTCYSSSSYRL----RNCN-----SRRH---------------RNHRR---------- 126 African savanna...
XP_003483151  81 -AKAHDVHLHCTLDPVEVKMAQPTCYSSFSYHHLCNRSRRR------RRR---------------RRSRS---------- 128 pig
XP_004887112  80 -AKAQDVHVHCILDPVQAKMARPTRYSSSSSHYLLNGHSR---------R---------------RCRRR---------- 124 naked mole-rat
XP_004760363  81 -AKPQDVHVHCTLEPMEVKLARPVCYPSSSYHHLRSSRSCR-----HRRP---------------RRHRH---------- 129 domestic ferret
XP_003466222  80 -AKAQDIHVHCTLDPVQVKMAPPTHSSASSGQYPFNCHRRR-----RYQP---------------RPR------------ 126 domestic guinea...
XP_849713     78 -AKAQDVHIHCTLDPVEVKMAPPDCYPSSSYHLGHNSRCCR-----RPCSrrcrsrrspgprrgpDHHHH---------- 141 dog

Q0P670       134 --C----------Rr----------------------rC------CNHQQRPQNYRQIPHSHSVFRNPHRSQKMSQLHRV 173 human
Q68FV4       131 --RgslqirqsnqQq----------------------sC------HSRQQRLRNNRQFSHGYPPFRKQRQSHKASQTRPM 180 Norway rat
XP_002718851 129 --R----------S------------------------RrqgmplCSHQQRPQNPRRFPRGRPVFRNQHHGYKVPKLRPK 172 rabbit
XP_003791318 139 rrY----------R------------------------R------CRPQQRTQNRRRFSHGRSGFCNQHHSHKMSQPRPM 178 small-eared galago
XP_003416943 127 --R----------H------------------------P------FSHQQRPKNHRQFRHGCPVFRGLRGSHKMSHLRPM 164 African savanna...
XP_003483151 129 --R----------R------------------------A------CSHQWRPKTHRRFPYSRSVFRRPHGSHKMAQLRPV 166 pig
XP_004887112 125 --F----------H------------------------H------HYRQQKPQNHKQFPKGCPIFHNQPYGYKTSQPQPV 162 naked mole-rat
XP_004760363 130 --R----------PrsrgprqrhghghrhhhhhhhhhdS------CSHQWGLKNQKHLCHNRSAFRSHHQGRKMSQLRVV 191 domestic ferret
XP_003466222 127 -----------------------------------------------------NHKQFPRGFRIGHNQPYGCKTLKPRPV 153 domestic guinea...
XP_849713    142 --P------------------------------------------CSHQWGLKNGRHVRHNRSGFHSHHHSRKMSQLRPV 177 dog

Q0P670       174 PFFDQEDPDSYLeeEDNLPFPYPKYP-RRGW-GGFYQRAGL-PSNVGLWGHQGGILASLPPPSLYLSPELRCMPKRVEAR 250 human
Q68FV4       181 PFFDLEDRDSLL--EDDQSCPHPKQP-RRSR-GGLYKPVRL-ASNAGLWGRQGGILASLPLPSLYLSPEMRRLPKRVEAK 255 Norway rat
XP_002718851 173 PFFDLEDRDSCLeeEEDLSFPHSKYP-RRGW-GGFYPRMALpPSSVGLWGRQGGILASLPPPSLYLSPELRRLPKRVEAK 250 rabbit
XP_003791318 179 SYLDGEDQDPYLeeEDDMAFPYPKYP-RGGW-GGLYPRMGL-PSNVGLWGRRGGILASLPPPSLYLSPELRRMPKRVEAK 255 small-eared galago
XP_003416943 165 PSLDREDQDSYLedEDGLSFPQPKYP-HGGW-GGLYPRLGL-PSNLGLWGRQGGILASLPPPSLYMSPELRRMPKRVEAK 241 African savanna...
XP_003483151 167 SSFDPEDLDSYLeeE-DLSPPRPKYL-PGGWgGGLYPQMGL-PSNVGLWGRQGGILASLPPPSLYLSPELRRLPKRVEAK 243 pig
XP_004887112 163 PFFDLEDRDPYLeeLEDPSSPILKYP-HRCK-GGVYQQMDV-PSIVGLWGHQGRNLASLPPPSLYSSPELRRLPKRVEAK 239 naked mole-rat
XP_004760363 192 PSFGG-DLDSYLeeE-DLAFPHPKYP-RGGW-GGLYPQRGL-PSNVGLWGRRGGILASLPPPSLYLSPELRRMPKRVEAK 266 domestic ferret
XP_003466222 154 PFYDLEDQDPYVeeLEDSPFPVLKYPhHRGR-GGLYQRKDV-PSIVGLWGRQGGILASLPPPSLYLSPELRRLPRRVQAR 231 domestic guinea...
XP_849713    178 PFF----DGEDLeeEDDLAFPHPKCP-WGRW-RELYQHRGL-PSNLGLWGRQGGILASLPPPSLYLSPELRRLPKRVEAK 250 dog

Q0P670       251 SELRLQSY 258 human
Q68FV4       256 SELRLQGF 263 Norway rat
XP_002718851 251 SELRLQSY 258 rabbit
XP_003791318 256 SELRLQSY 263 small-eared galago
XP_003416943 242 SELRMQSY 249 African savanna elephant
XP_003483151 244 SELRLQSY 251 pig
XP_004887112 240 SELRLQSY 247 naked mole-rat
XP_004760363 267 SELRLQSc 274 domestic ferret
XP_003466222 232 SELRLQAY 239 domestic guinea pig
XP_849713    251 SELRLQSY 258 dog
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