pfam15782: GREB1 (this model, PSSM-Id:292410 is obsolete and has been replaced by 464866)
Gene regulated by oestrogen in breast cancer
GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.