Conserved Protein Domain Family
NupH_GANP
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pfam16768: NupH_GANP (this model, PSSM-Id:293373 is obsolete and has been replaced by 435572)
Nucleoporin homology of Germinal-centre associated nuclear protein
NupH_GANP is the nucleoporin-homology domain at the N-terminus of human GANP or germinal-centre associated nuclear proteins. GANP is part of the TREX-2 complex that links transcription with nuclear messenger RNA export, and it associates with the mRNP particle through the interaction of the NupH_GANP with NXF1, the export factor. This attachment mediates efficient delivery of mRNPs to nuclear pore complexes.
Links
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Statistics
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PSSM-Id: 293373
Aligned: 12 rows
Threshold Bit Score: 218.184
Created: 17-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007485976    2 NSNNPFGGQQSSLF-STPSGaSLGTFQVQP----------PFR--------------------FGQPS----LFGQNNVG 46   gray short-ta...
XP_003277443    2 NPTNPFSGQQPSAF-SASSS-NVGTLPSKP----------PFR--------------------FGQPS----LFGQNSTL 45   northern whit...
XP_002716900    2 NPPNPFSGQQPSAF-PTSASgSIGTFQAKP----------PFR--------------------FGQPS----LFGQNNTL 46   rabbit
XP_004842601    2 NPVNPFIGQQPSAF-AASSSgTAGTFQSKP----------PFR--------------------FGQPS----LFGQNNTL 46   naked mole-rat
XP_006104865    2 NPPNPFSGQQPSAF-LTSSSsSIGTAQAKQ----------PFR--------------------FGQPS----LFGQNNTV 46   little brown bat
XP_011223048   13 NPTNPFSGQQPGVF-PASTSsSIGTFQAKP----------PFR--------------------FGQPS----PFGQNNTL 57   giant panda
ERE88049        2 NPVNPFSGQQPGAF-AVSSSt-TGTYQTKS----------SFR--------------------FGQPP----LFGQNNTL 45   Chinese hamster
ETE65289        2 NPSTPFSGQPSGVF-QSSPGaSAGMFSSQP----------PFQ--------------------FNQLS----LFGLNSGG 46   king cobra
XP_008112685    2 NPNTPFSGQQPGGF-QVPSGpATGIFPAQP----------SFQ--------------------FGQPP----IFGQNTGS 46   green anole
XP_011487897    2 NPSGTFGSSQGGAF-QAPGGtMKTSLFGQPfgqqnpssqgLFQppafgqqpvmnqsaghgnpiFGQTP----VFGQSQPS 76   Japanese medaka
XP_005463418   60 spafgqpSAQASAFgQPSAQaSAFGQPSAQ----------ASA--------------------FGQPSaqasLFGKPPSG 109  Nile tilapia
XP_012405528    2 NPNSLFGGQQSSM--FSSTSgSLGTFQVQP----------PFR--------------------FGQPS----LFGQSALG 45   Tasmanian devil

XP_007485976   47 S--GQNVGF----------A--QTSGFAQAAGVGQAPS-GATIGFPPTSGLGLYP-T-QGQAPALTATSGPPGSSVPSNP 109  gray short-ta...
XP_003277443   46 S--GKSSGF----------S--QVSSFPASSGVSHSSS-VQTLGFTQTSSVGPFS-G-LEHTSTFVATSGPSSSSVLGNP 108  northern whit...
XP_002716900   47 S--GKNSGF----------S--QASSFPAASGVSHSSS-VQTLGFAQTSSAGLFS-G-LEHTPTFAATSGPSSSSVPANP 109  rabbit
XP_004842601   47 S--GKSPGF----------S--HMPSFGTPSGITHSS--GQTFGLTQTSSSGLFS-G-LERAPPFVATSGPSSSSVPGNP 108  naked mole-rat
XP_006104865   47 S--GKSSGF----------S--QISSFP-TSGVGHSSS-AQTLGFSQTSNVGLFS-G-LEHTPSFLSASGPSSSCVPGNP 108  little brown bat
XP_011223048   58 S--GKTSGF----------S--QVSSFPTSSGVSHSSS-AQTLGFSQTSNAGLFP-G-LEHTPAFVAASGSSSSCVSANP 120  giant panda
ERE88049       46 ---GKSLGF----------S--QVSSFATPSVVSHSSS-LPTFGVTQTSSVGLFA-T-LESTPSFAATSGPSSSSVPGNT 107  Chinese hamster
ETE65289       47 ---VKNPGF----------T--HLSDF--TTGL-HNSS-GQGLGFGQLPGFTQSY-S-LGETTTFVTTA-PMTASVTSKS 104  king cobra
XP_008112685   47 GalLKNPGF----------T--HLTDFTVTAGA-RSS-----LSLGQTPGFAQSY-T-AAPTTSFVTSA-PTYSSVPSKQ 105  green anole
XP_011487897   77 StvSSAPAFgqqplgtfgnT--NASSFGQNSVSNQGSVlGPGSGFGQPPAFGVTS-A-FG-----------SNPTLGQPQ 141  Japanese medaka
XP_005463418  110 ---VSSTGF----------GggTTPAFGQTGGPGQSSMfGQTPAFGQASGFGKQP-PaIGQQPSGFGS--PLRPAVSQPQ 173  Nile tilapia
XP_012405528   46 A--GQN--------------------FAQTSGGTQSSS-GSTLGFPANSGIGSHSvP-PPQAPVFTAASGPPSTSAPSNA 101  Tasmanian devil

XP_007485976  110 GFSFKPPT---NLGAFPGTTSFGLSSGETASCGLGRPEFSFKPPESATFRPIFGAESESEKTQSQVTPGS---------- 176  gray short-ta...
XP_003277443  109 GFSFKSPT---SVGAFPSTSAFGQEAGEIVNSGFGKTEFSFKPLENAVFKPILGAESEPEKTQSQIASGF---------- 175  northern whit...
XP_002716900  110 GFSFKSST---NLEVFPSTSTFGPEGGELPGSGFGKTEFTFKPLENAVFRPILANESEPEKTQSQITSGF---------- 176  rabbit
XP_004842601  109 GFSFKSPT---SLGVFSSTTAFGSEAGEVVSSGFGKTEFSFKPLENAVFRPILGTESEPEKTQSQITSGF---------- 175  naked mole-rat
XP_006104865  109 GFTFKSP----NLGAFPSTSTFAPETGEVASYGLGKTEFSFKSLENSVFRPILGAESEPEKTQSQITSGF---------- 174  little brown bat
XP_011223048  121 GFSFKSP----SFGAFPSTSTFGPETGEVASSSFGKTEFSFKPLENSVFRPIFGAESEPEKTQSPVTSGF---------- 186  giant panda
ERE88049      108 GFSFKSPS---SVGVFPSGSTFGPETGEVASSGFRKTEFKFKPMENAVFRPILGAESEPEKTQSQIASGF---------- 174  Chinese hamster
ETE65289      105 GFSFRPPT---NLGNSQSTSAFGTVRGETSAGGFVRSDFSFKSSENAMFKPIFGTNSEQEKIPTSAASSF---------- 171  king cobra
XP_008112685  106 AFSFKPPT---ALGPSHCPPNFGATSTDTSGSGFVGPDFSFKTPENAVFKPIFGTGSGQEKLANTGNQPS---------- 172  green anole
XP_011487897  142 PLFFGQTSfgqTSSTSSSTSVFGQTPNITQSRGFGSSEFSFKPANDAIFKPIFSASPEPTNPQITPVSGS---------- 211  Japanese medaka
XP_005463418  174 PLGFGQPS---SSSTSATTNTSLRGPG--QNRSFAPSEFSFRPANEALFKPIFSASPEPTNPTTTSLSNSafggsqttss 248  Nile tilapia
XP_012405528  102 GFSFKTPP---NIGAFPSTPSFGHGSGE--ASGLGRSEFSFKPPESATFRPIFGAESEPEKTQSQITPGS---------- 166  Tasmanian devil

XP_007485976  177 -----------------FTFSHP-----VSSGPEALGSFTFSQGSSGAGTGPNFTFSKP-Sg------------------ 215  gray short-ta...
XP_003277443  176 -----------------FTFSHP-----ISSAPGGLAPFSFPQVTSSSATNSNFTFSKPvSs------------------ 215  northern whit...
XP_002716900  177 -----------------FTFSHP-----ISSGPGGLAPFSFPPVTSSSTTNSNFTFSKPvNt------------------ 216  rabbit
XP_004842601  176 -----------------FTFSHP-----VNSGPGGPTPFSFSQVTSSSAPNSSFIFSKPvNs------------------ 215  naked mole-rat
XP_006104865  175 -----------------FTFSQP-----ISSGPGGQAPFSFTQVTSS-ATKSNFTFSKPvDs------------------ 213  little brown bat
XP_011223048  187 -----------------FTFSHP-----ISSGPGGLAPFAFPQVTSSSAANSNFTFSKPvNs------------------ 226  giant panda
ERE88049      175 -----------------FTFPHP-----VSSGSGSLTPFSFSQVTNSSVTSSNFVFSKPaNs------------------ 214  Chinese hamster
ETE65289      172 -----------------TF-SSP-----SGAGFGKLTPFVMSQESSNSN-NTGFSFSKPvNs------------------ 209  king cobra
XP_008112685  173 -----------------FTFSSP-----GTSGSGRLAPFAMSQASSSTASTSF-SFSKPlSs------------------ 211  green anole
XP_011487897  212 ------------------SFCAA-----GSQVSSS-TNAGFSFLTGSKAGPAGFNLSQPaPvsssssqnnslttacgdqt 267  Japanese medaka
XP_005463418  249 ttttsdfpllpksesldFSFSEPasapsISSQSNPLS----TDSSSGPATTLQFTFSQPaTl------------------ 306  Nile tilapia
XP_012405528  167 -----------------FTFSHP-----VSGGPEALVSFTFSQGSSSSGTSPSFTFSKPaSn------------------ 206  Tasmanian devil

XP_007485976  216 -----NTPSSAFASASSGQNSEEEKRGPKPAFGSAGSSFTSFAGsLPGSVGEPFALSKAASKQGR-DDLGGQGGSLPGHM 289  gray short-ta...
XP_003277443  216 -----NNSLSAFTPALSNQNVEEEKRGPKSIFGSSQNSFSSFPV-SSAVLGEPFQASKAGVRQGC-EEAVSQVEPLPSLM 288  northern whit...
XP_002716900  217 -----NNSSSAFAPALSGQNAEEEKRGSKSGFGSCNSS-FSSFPmSSVSGGESFPVSKTGVRQGC-EEAVSQVEPLPSLM 289  rabbit
XP_004842601  216 -----NNSSSPFNPALSNQNVEEEKRGPKSVFGSCNSNFSSFPV-SSGSLGEPFSVNKSGVRQGC-EEAVSQVEPLPGLM 288  naked mole-rat
XP_006104865  214 -----SNSSSPFALALSSQNVEEEKKGPKSLFGSLNSSFTSFPTsSSGSLGEPFPVSKTGARQGC-EETVSQVEPLCSFM 287  little brown bat
XP_011223048  227 -----NNSSSAFTSALPNQNVEEEKRAPKSLFGSSDSSFTNFPI-SSGPLGEPFPVSKTGVRQGC-EERVSQMEPLPSLM 299  giant panda
ERE88049      215 -----NTTSV-LTPALSNQNVEEEKRGPKSVFGSSNSSFTTFPMpSSASLGEPFSGNKTVIRQGC-EEAISLVEPLPTPM 287  Chinese hamster
ETE65289      210 ----sSTSAVSFSTSLPSKTLADDKKRPMALFTSPGSSFSSFSNpSL-PLRDTFQVNKTNKMEH--EDLFIPSEPLPTLG 282  king cobra
XP_008112685  212 -----NTSASSFSVALPSKTTEDDKKRPTVFFASPSSSFTSFSNsSTGSLLDPFQMNKTAKLQH--EEIVAPVEPHSLFG 284  green anole
XP_011487897  268 ktlpfSFSQPAVPPISSTTASIKEPTTP--------SSF-SFSLkNFQTQPTPLSVGAGFDQLSAfGEPKSKVETSLDkn 338  Japanese medaka
XP_005463418  307 -----TSS--------STKAATTEPTTP--------SSF-SFTPkTLQPQAAQLFAGTTFGQSSAfSETKTKEEASTDVK 364  Nile tilapia
XP_012405528  207 -----SSTFAS-----SSQNVEEEKRGPKPTFGSSGNSFPSFA--SPGSVGEPFSMSKAVGKLGR-DDAGGQGGLLSGHV 273  Tasmanian devil

XP_007485976  290 KGL 292  gray short-tailed opossum
XP_003277443  289 KGL 291  northern white-cheeked gibbon
XP_002716900  290 KGL 292  rabbit
XP_004842601  289 KGL 291  naked mole-rat
XP_006104865  288 KGL 290  little brown bat
XP_011223048  300 KGL 302  giant panda
ERE88049      288 KGL 290  Chinese hamster
ETE65289      283 KGM 285  king cobra
XP_008112685  285 KGT 287  green anole
XP_011487897  339 dsn 341  Japanese medaka
XP_005463418  365 vht 367  Nile tilapia
XP_012405528  274 KGL 276  Tasmanian devil
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