Conserved Protein Domain Family
LDLa

?
cl00104: LDLa Superfamily (this model, PSSM-Id:294076 is obsolete and has been replaced by 412164)
Click on image for an interactive view with Cn3D
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
Links
?
Statistics
?
Accession: cl00104
PSSM Id: 294076
Name: LDLa
Created: 8-Feb-2008
Updated: 2-Feb-2016
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap