Conserved Protein Domain Family
Myosin_TH1
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pfam06017: Myosin_TH1 (this model, PSSM-Id:310539 is obsolete and has been replaced by 461801)
Unconventional myosin tail, actin- and lipid-binding
Unconventional myosins, ie those that are not found in muscle, have the common, classical-type head domain, sometimes a neck with the IQ calmodulin-binding motifs, and then non-standard tails. These tails determine the subcellular localization of the unconventional myosins and also help determine their individual functions. The family carries several different unconventional myosins, eg. Myo1f is expressed mainly in immune cells as well as in the inner ear where it can be associated with deafness, Myo1d has a lipid-binding module in their tail and is implicated in endosome vesicle recycling in epithelial cells. Myo1a, b, c and g from various eukaryotes are also found in this family.
Links
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Statistics
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PSSM-Id: 310539
Aligned: 192 rows
Threshold Bit Score: 95.3336
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2HDI2        760 RDDGHRVLQGRKERRRMSILgsR---RFLGDYLGI-NASTGPGAQMRNGMQLGNNERAVFSCRgevlEAKFGRSSKPSPR 835  Chaetomium gl...
XP_004349469  713 KQKATDILFGKKERRRGSLN--R---NFVGDYIGFqDN-----PALRALLPKK--ERVEFACD----VMKYDRRFNGQKR 776  Capsaspora ow...
XP_009030550  706 KNEASSLVLNKKERRRFSID--R---SFVGDYLGLeHK-----PGLRAL--LERREMVEFADA----VNKYDRRFKPSKR 769  Helobdella ro...
XP_006681821  689 RKKAADVMFNNKERKRFSLN--R---EFLGDYINFlDN-----PILKSLVGK--DVKAGFVDA----VTKYDRNFKPTQR 752  Batrachochytr...
EFA79585      789 KNYSQNLFQGKKERNRDSLV--LsslAFIGDFLSVaNDDYTKQVLARE---EGPNASVRLSVS----VSKINRHQKIQKR 859  Polysphondyli...
XP_002414115  601 KQLAADILNGRKERRRHSLN--R---NFVGDYIGLdHH-----PELRVLVGK--RERIEFAET----VFKYDRRFKPVKR 664  black-legged ...
EFX90240      709 REQAAEIVFGKKERRRFSLN--R---GFVGDYIGLdNQ-----PALRALVGK--REKIEFAET----VFKYDRRFQATKR 772  common water ...
EGI64068      346 IQEAADLLFGHKERKRETLN--R---NFFGDYIGLeDK-----PQMMSLIGR--REKVFFAEV----VKKYNRRFKTCRV 409  Panamanian le...
EFN77966      322 KQEAAGLLFGRKERRRASLN--R---NFVGDYIGLeTK-----PQTMSLIGR--REKVFFAEV----VKKYDRRFKMCRR 385  Jerdon's jump...
XP_008203897  716 KQEAADLLYGHKQRRKASLN--R---NFVGDYIGMdMK-----PRLASLVGK--REKILFAEV----VKKYDRRFKMCRR 779  jewel wasp

Q2HDI2        836 TIVVTNNKFYVVALVmgQ------Nn----qPQVILERSFPLGAIKFISTSTARDDWFSLGVGSQqEA-DP--LLNCVLK 902  Chaetomium gl...
XP_004349469  777 DLLLTSQALYLVALEkvQ------KgpekgkLVLEVKRRIEMAQISGVTLSPFQDDFVILHVPS--EY-DN--VFELIFK 845  Capsaspora ow...
XP_009030550  770 DLIITNKFFYLIGREqvKkgpqkgQ------VLEVIKRKIPLEGISHFALSTRQDDFFILYT----LD-DYanLMECTFK 838  Helobdella ro...
XP_006681821  753 EIIVSDTHLFLIGAEkqK------NgpnkgkFVKVVKRKIPLGDISSLSLSTKCDDFFVLHVAS--DF-DN--IFENVLK 821  Batrachochytr...
EFA79585      860 ALIVTNSNILHISTHkpKk----dG------SWFVVKRKIAFSALEKVSLSHLCDNFFVLHVPSE-T--DY--ICETNRK 924  Polysphondyli...
XP_002414115  665 DLILTPKSVFLVGREkvKkga-dkGk-----IREVVKRRIDLENISQVTVSTRQDDFLVIQVKn---DyDS--FLESVFK 733  black-legged ...
EFX90240      773 DLILTGKTIFLIGREkvKkgp-kkGq-----IIEVVKRRIPIETIRQISTSTKQDDFIVLQVNn---EyDT--LIRSIFK 841  common water ...
EGI64068      410 DLILTGKCIYLIGREqiKnd--skDk-----SIEVIKRKLSFNQISCVSLSKLTDNFIIIHVKe---DyAS--VLESVFK 477  Panamanian le...
EFN77966      386 DLVLTGKCLYLIGREqvKkga-ekGk-----SILVIKRKLPFSQISHVSLSMLQDNFVIIHTRe---DyAS--LLESVFK 454  Jerdon's jump...
XP_008203897  780 DLILTGKCLYLIGREpiKkgp-ekGr-----SVEVIKRKLPFEQISHISLSTLQDDFIVIHTRe---DyAS--LLELVFK 848  jewel wasp

Q2HDI2        903 TEMFTQM-----KRVMPgGFNLKIGDTIEYAKKP-----G------K------MQLVKVLKd----aPT-------P--- 946  Chaetomium gl...
XP_004349469  846 TEFLTTLsdkylAATQR-KLTVNFSDKIQYTVKK-----GgfmdsaG------TRMIAFSY------GQ-------Gdla 900  Capsaspora ow...
XP_009030550  839 TEMLSVLnklstAQGRG-ALKIHFNDSIEYVTKK-----D------Kffg-asKLTVKFSS------GA-------Gnma 892  Helobdella ro...
XP_006681821  822 TELVAVLsekfqIATGR-PLVINFTDTIKYTVKKttwqsG------G------ILELRFIVdnavrlPV-------A--- 878  Batrachochytr...
EFA79585      925 TVFITLLsklyeKQQSK-PLNIEFSDSIAYRTQK-----G-------------NTEAKFTKvdqlpkeqlytakaergni 985  Polysphondyli...
XP_002414115  734 TEFLFALdkkmkEKCHR-PLNLHFADRLEFRVKK-----E------GlfgggsTKVVNVT--------S-------Ghgd 786  black-legged ...
EFX90240      842 TELMSTLnrklrENFNR-VLNMNFTDNMEVSIKK-----E------Gwsg-ggLRQVKVI--------A-------Gtge 893  common water ...
EGI64068      478 TEFLYILskkylEDTGH-PLNIIFSNDLQFKIKK-----E------Gwgg-ggMRYIKFT--------QtvdnddvIhnn 536  Panamanian le...
EFN77966      455 TEFLSVLdkkylEDTGH-PLNIKFSNNLEFKVKK-----E------Gwgg-ggMRQLKFT--------Ql------Dygd 507  Jerdon's jump...
XP_008203897  849 TEFLSVFskkyaEEMGH-SPNIKFSNSIEFKVKK-----E------Gwgg-ggTRQVKFV--------Qa------Gygd 901  jewel wasp

Q2HDI2        947 ----HDFYKSGAVHT 957  Chaetomium globosum CBS 148.51
XP_004349469  901 --ivKPGGKGGIVTI 913  Capsaspora owczarzaki ATCC 30864
XP_009030550  893 --vlKPSSKVLTVSI 905  Helobdella robusta
XP_006681821  879 ----KHSNKVTEIRV 889  Batrachochytrium dendrobatidis JAM81
EFA79585      986 kisvlegqnpdsksf 1000 Polysphondylium pallidum PN500
XP_002414115  787 kavlKVTGGALTVSI 801  black-legged tick
EFX90240      894 dpslKVSGKTLIVSI 908  common water flea
EGI64068      537 kqilKPFSKILNVSI 551  Panamanian leafcutter ant
EFN77966      508 reilKSSGKILNISI 522  Jerdon's jumping ant
XP_008203897  902 kevlNSSGKILTVSI 916  jewel wasp
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