2H2N


Conserved Protein Domain Family
Apyrase

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pfam06079: Apyrase (this model, PSSM-Id:310576 is obsolete and has been replaced by 461822)
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Apyrase
This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate..
Statistics
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PSSM-Id: 310576
Aligned: 50 rows
Threshold Bit Score: 346.839
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H2N_A        52 DTESRa--qEENTWFSYLKKGYLTLSd-------SGDKVAVEWDK-D--H---GVLESHLAEKGRGMELSDLIVFNGKLY 116 human
XP_627524     55 DMNSKpg-nGEKNYKSLFQKGSI-IQd-------KRGNYRVDWGE----I---LELKSGYNEYGRGMELSELISYNGMML 118 Cryptosporidium...
XP_002140694  55 DLKSRpsnpGEKDFRSILQKGRIYFDt-------KEEQYKVTWDA-A--L---VLL-SGHNEYGRGMELSELVIYDGKLL 120 Cryptosporidium...
XP_008856293  37 DKASK----EGQMWRSVVIVGII-----------FRQGNSYDFQEqE--E---FNISLPINENGRGMELSELLSFNGSLY 96  Entamoeba nutta...
XP_011129432 104 DERSLvk-gDKPHYESRMMFGSLFMDe-------Q-EQVHVTWKT-AgmP---MKIMGGLAESGRGMELSELVLWNGQML 170 Gregarina nipha...
XP_656157     75 DNDKYn--vEDNKFISKIHFGMI-----------SKIDNKWSFTE-N--TqksFQTQTQLNYNGRGNELSEVIQYFNNLY 138 Entamoeba histo...
XP_002674693  70 DKDSKy--kNDFKWRSFVIKGIVKRk--------ANGKYSIEFGK-D--Ns-kFEIQSLLARRNRSMELSTLSLWRGKFY 135 Naegleria grube...
XP_648646     37 DKASK----EGQMWRSVVIVGII-----------FRQGNSYDFQE-Q--Ee--FNISLPINENGRGMELSELLSFNGSLY 96  Entamoeba histo...
XP_012899038  76 DKESRvkddKKGRWRSILKKGELRKQ--------KDGTFTIHWLE-D--Q----EIFTQLSEAGRGMELSALVEYHNRLY 140 Blastocystis ho...
XP_002895412 144 DKKSKddnsKKPQFLSYIMHATLKVTpgsssathKRDAYSVTFGE-E--T----KFSTHMNEAGRGFELSELAWFDGKLL 216 Phytophthora in...
2H2N_A       117 SVDDRTGVVYQI--E-------------------GS--------K--------AV-PWVILSDGDgTVEKGFKAEWLAV- 157 human
XP_627524    119 AGDDRTGIIFEI--T-------------------DD--------Gk------gVA-PRYILSEGNgRTAKGMKIEWFAV- 161 Cryptosporidium...
XP_002140694 121 AGDDRSGIMFEI--I-------------------DDg-------K--------VIaPRYILSEGDgNKGKGMKIEWATV- 163 Cryptosporidium...
XP_008856293  97 GFDDRTGLVCAIdiE-------------------KK--------K--------AY-PRLILRDGDsFSDKGMKIEWATV- 139 Entamoeba nutta...
XP_011129432 171 AFDDRTGIVYEL--ItvledgttsplvdtvmrhkDDdteprwsvK--------PL-PRYVLTE-DpNSVKGMKVEWACE- 237 Gregarina nipha...
XP_656157    139 VFDDKTGVIAQL--Dl------------------DH--------Kn-------FY-PWIIIADGNgNQTSGAKNEWATV- 181 Entamoeba histo...
XP_002674693 136 ATCDYTGIVYEIdmE-------------------QE--------R--------AY-PRHVLYSGDgNTKIPLKAEWSTVg 179 Naegleria grube...
XP_648646     97 GFDDRTGLVCAId-I-------------------EK--------Kk-------AY-PRLILRDGDsFSDKGMKIEWATV- 139 Entamoeba histo...
XP_012899038 141 SFDDRTGLVFELv-K-------------------GN--------K--------AI-PRYILMEGDgNTTKGQKTEWATV- 182 Blastocystis ho...
XP_002895412 217 AFDDRTGIVFRLk-H-------------------FE--------GisrtkplqAI-PEHIIMEGDgFNGKGQKHEWATV- 266 Phytophthora in...
2H2N_A       158 KDERLYVGGLGKEWTTTTG-DVVNENPEWVKVV-----------G-YKGS----VDHENWVSNYNALRAAAGIQPPGYLI 220 human
XP_627524    162 RDGILWVGSFGKEFV-SNG-IIEKRDNMWVATI-----------D-KRGH----VSRFNWSFVYEKIRNSLGAQYPGYCI 223 Cryptosporidium...
XP_002140694 164 RDDVLWVGSFGKEFVQ-NG-IISKQDNMWVASV-----------D-KFGN----IRYYNWSKVYNSIRSALDADFPGYCI 225 Cryptosporidium...
XP_008856293 140 YKDSMYVGSIGKEFTTPRG-EYLNDNPLYVKQI-----------N-VDGK----VSVLNWKNKFNAIKNAVGIYGEGYMI 202 Entamoeba nutta...
XP_011129432 238 VDGDLMVGSFGKEYTTGDGsQITGEANFWVARIeaprnknkpglR-SNGSpqpiVEKINWKGQYNRLRELTRTSYPGYMI 316 Gregarina nipha...
XP_656157    182 VGDKLYVGSHGPNTYDSLG-RVDRTNKYYIQKV-----------N-KEGS----FEYEDWSGVYNNILNALNIEVPGYIT 244 Entamoeba histo...
XP_002674693 180 PDDRLYIGSIGKEWV-ANG-EALNRHCEWVKVI-----------DrKSYK----EISVDWGEVYMRLRQSVNATEPGYLI 242 Naegleria grube...
XP_648646    140 YKDSMYVGSIGKEFTTPTG-EYLNDNPLYVKQI-----------N-VDGK----VSVLNWKNKFNAIKNAVRIYGEGYMI 202 Entamoeba histo...
XP_012899038 183 KDDAILAGSFGKEYTNADG-SIANTNNMWVSVI-----------H-NTGE----ITHENWTDRFNKLRKAAGCPYPGYMI 245 Blastocystis ho...
XP_002895412 267 KDGELYMGSVGKEFTDNDG-NVIGDGNLWVAVM-----------N-RAGE----VRHEDWTANFAAVRKALGCEWPGYVV 329 Phytophthora in...
2H2N_A       221 HESACWSDTLQRWFFLPRRASQE-RYSEKDDERK-GANLLLSASPDFGDI-AVSHV--GAV--VPTHGFSSF-------- 285 human
XP_627524    224 HEAVIWSHLMRKWIFLPRRVSFD-EYDEEKDEKR-GSNKMIIMTDDFEIL-EIIDV--GLI--IPERGFSSL-------- 288 Cryptosporidium...
XP_002140694 226 HEAVGWSPYMRKWIFLPRRVSNE-PYDEFLDEMK-GSNKMVILSDDLEIL-DVKAI--GDI--IPERGFSSF-------- 290 Cryptosporidium...
XP_008856293 203 HEAVAYSASANKWYFAPRKCSNE-RYDDIKDEVR-GCPYIIST-KDFIHF-NIINDpqHDF--NK--GFSSI-------- 266 Entamoeba nutta...
XP_011129432 317 HEAVNYSDKKKKWFFLPRRISKE-QYDEVLDESR-GASLILEVDPSFSDL-VSYPIdfAVQ--QPHRGFSSF-------- 383 Gregarina nipha...
XP_656157    245 NEAVVYSNLKKKWYFAPRKCSNK-AYDKQEDEELnNCKYIIELDENLNNP-RLIED--KQY--DKTHGFSSI-------- 310 Entamoeba histo...
XP_002674693 243 HESVFYDKFLKEWIFLPRRHSEDvKYNEKSDEYL-GANIMIRTDIDLQQVkKVVRV--GRKseNPEEFYDNFldkrfgft 319 Naegleria grube...
XP_648646    203 HEAVAYSVSDNKWYFAPRKCSNE-RYDDIKDEVR-GCPYIIS-TKDFIHF-NIINDpqHDF--N--KGFSSI-------- 266 Entamoeba histo...
XP_012899038 246 HEAIMWSDIRRQWVILPRRVSKE-PYDEKEDEKR-GSNVVMLASEDFSSI-EVRHI--TQI--TPTRGFSEF-------- 310 Blastocystis ho...
XP_002895412 330 HEAIEWSPVRRQWFILPRRVSTE-PYNDMEDERR-GSNKIIIASEDFSSI-QVREV--GKV--TPLRGFSSF-------- 394 Phytophthora in...
2H2N_A       286 ---KFIPNTDDQIIVALKSEE--D---S--GR--VASYIMAFTLDGRFL---------LPETKI-GSV-KYEGIEF 338 human
XP_627524    289 ---KFLPGSFDQIIVATKSVEesI---S--DT--QKSFLTIFTINGKIL---------MEDLEVpGDY-KYEGIEF 344 Cryptosporidium par...
XP_002140694 291 ---KFLPGSKDQIIVALKTVE--N---SriDF--QSTYVSMFTIDGDLL---------IDDIKVpGEF-KFEGIEF 346 Cryptosporidium mur...
XP_008856293 267 ---KVLPHDENKLI-YLKSVE--V---G--KR--SETYMGMISTTGEVI---------MKEKLI-TKM-KMEGIEF 318 Entamoeba nuttalli P19
XP_011129432 384 ---KFMPGTNDEIIIAVRSVE--V---A--KRreTQTFLSVFDVKGKVY---------MNEVNI-SEYcKYEGLEI 439 Gregarina niphandrodes
XP_656157    311 ---KVLPFNED-ILVYLKSYE--V---D--NK--FKSFIGMINVNGEIV---------MEEQPL-GSE-KFEGLEI 362 Entamoeba histolyti...
XP_002674693 320 divRLTKTAGNNHYLATRVIE--VshpE--EI--VETYLTIFDDNGVVLldsptgvleLPEELG-KGE-KYEGIEv 387 Naegleria gruberi s...
XP_648646    267 ---KILPHDEN-KLIYLKSVE--V---G--KR--SETYMGMISTTGEVI---------MKEKLI-TKM-KMEGIEF 318 Entamoeba histolyti...
XP_012899038 311 ---KFLPQSNDEIIVALKSEE--Ne--E--QQt-QNSYITVFDLDGHIL---------LSESVIpGNH-KFEGLEF 366 Blastocystis hominis
XP_002895412 395 ---KFVPRSDDSVIVAIKSVE--Ve--D--EEr-QTSYITVFSVDGNVL---------MEETEIpGAK-KYEGVAF 450 Phytophthora infest...
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