Conserved Protein Domain Family
Cas1_AcylT
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pfam07779: Cas1_AcylT (this model, PSSM-Id:311634 is obsolete and has been replaced by 462263)
10 TM Acyl Transferase domain found in Cas1p
Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.
Links
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Statistics
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PSSM-Id: 311634
Aligned: 21 rows
Threshold Bit Score: 500.268
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6CDI8        313 SDTCCIHYkQPRTMGQVLLLGVi-------CAILPIIYLGQRYTRSDyyprfvryvSWPVPSIQD--------------- 370  Yarrowia lipo...
XP_002127948  292 DGTCCRKP-DPLTIVQIIM-AVlg----fiFILLAVGIRIQRIGKPT---------PTNEDEVAKnkdsi---------- 346  vase tunicate
XP_009029734  256 DGSCCTSP-ENPTTVQIAMAAFfatslaaaVLIATCRRLNGRSNKNN---------KNNNKTNNNnnnqs---------- 315  Helobdella ro...
XP_004347694  466 DVTCCAPY-PALTGLQYVFFAV--------VLFALVCWLGGSYAARH---------HTGGAVASGaesafgatararhml 527  Capsaspora ow...
XP_007803518  213 DKTCCNVQ-PPINLEQQVLIFVa-------TLTILYAFYSASKRKML---------NQPATTLLAv-------------- 261  Endocarpon pu...
EPT04032      328 DRTCCRRY-PWPSALHSLVLAVa-------VFWGPACVLLARRVAPP---------TSGQPYIGD--------------- 375  Fomitopsis pi...
XP_006011687  301 DASCCLPK-PSFTVIQKLTACFfg----isIIGFLIFSYLFRNNHKK---------SKPCTDVES--------------- 351  coelacanth
XP_014201210  230 DGSCCQPR-PPVTLIQKLAACFft----lsIIGYLIFYIIHRNAHRK---------NKPCTDLES--------------- 280  pygmy chimpanzee
XP_012821059  228 DGSCCQPT-PSLTIIQKLAACFfi----faMIAFVSVTIVQRNKHRR---------NKQCDDIES--------------- 278  western clawe...
XP_019206070  336 DGSCCQTL-RAPNLLQKLSALFfl----gsAVVFVVFHILGNNRHRR---------HVP-PDVES--------------- 385  Nile tilapia

Q6CDI8        371 -----E----------------TLLTACVVIAASLAYSFFCDRTQFFGKSSKQFEASEFWVLILLFLVATGYS------- 422  Yarrowia lipo...
XP_002127948  347 -hniiA----------------ELTYAAAKMSLILFYFYICDRTDVFMKSNKHYTNTRFFLPLLYIVFLGIFG------- 402  vase tunicate
XP_009029734  316 knmdcP----------------TLISCIAKLGLILLYFFICDRTTFFMKENKYYTHVNFFLPFTYLMILGLFF------- 372  Helobdella ro...
XP_004347694  528 sspnlL----------------SVAMPVAQLGLVLVFAFLCDRTHIFPKERKIYTHFDLIASIGVMFVAGWCT------- 584  Capsaspora ow...
XP_007803518  262 ---------------------nGITAAVGIIAMAVVYCFVADRTLIFDKVQKVSSQRTFLQMITIVMLGGVLTvrkpgdt 320  Endocarpon pu...
EPT04032      376 -----Qe------------------MPAVVMSVAAALIYLADRTDFWLKEQKQFSPWVFTFLSLLSLAAGLST------- 425  Fomitopsis pi...
XP_006011687  352 -----Geekpttat-papanteILLQSLCKLGLIMAYFYLCDRANLFMKEHKFYTNSTFFVPLIFILMLGVFC------- 418  coelacanth
XP_014201210  281 -----Geekkniin-tpvssleILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFY------- 347  pygmy chimpanzee
XP_012821059  279 -----GeekkpatatpaassleILLFSLSKLGLIMAYFYFCDRANLFMKENKFYTHSSFFIPIIYILVLGVFY------- 346  western clawe...
XP_019206070  386 -----Leekkpata-avppgpkAPFQALCRMGVIMGYFYLCDRADVFMKEQKFYTHSTFFIPLIYIFVLGVFY------- 452  Nile tilapia

Q6CDI8        423 --------FEPqNDN-S-FLNRHQTEEWKGWMQIIILIYHITGASKILPIYKFVRVLVAAYLFMTGFGHATFFIKRGDFS 492  Yarrowia lipo...
XP_002127948  403 --------IDS-TKQ-PvFLNRDQTDEWKGWMQLVILIYHVTGASVNVPIYMHVRLLVAMYLFMTGYGHFSYFWNKGDFG 472  vase tunicate
XP_009029734  373 --------TES-TKQ-VqVLNRCQTDEWKGWMQIVILIYHLTGASKVLSIYMHIRVMVSAYLFLSAYGHFVYFFNKNDFS 442  Helobdella ro...
XP_004347694  585 --------LTH-VKTaPtFLSRDQTDEWKGWMQIVFLIYHFLGGSSVLPLYMLVRVFVASYLFLTGFGHFTFFYTKKQFG 655  Capsaspora ow...
XP_007803518  321 saetsakpTRA-TLG-QkFLSRDQTDEWKGWMQFVILIYHYTGMSNVLWVYQIIRLLVASYLFMTGYGHTIYFLKTNNFS 398  Endocarpon pu...
EPT04032      426 --------MRQaDKD-LgFLNREQTDEWKGWMQIAILIYHYTGASKISGIYNVIRVLVAAYLFMTGYGHTTFYIKKADFG 496  Fomitopsis pi...
XP_006011687  419 --------NEN-AKE-SkLLNRDQTDEWKGWMQLVILLYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWIKDDLG 488  coelacanth
XP_014201210  348 --------NEN-TKE-TkVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFG 417  pygmy chimpanzee
XP_012821059  347 --------NEN-TKE-AkLLNREQTDEWKGWMQLVILIYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWLKGDFG 416  western clawe...
XP_019206070  453 --------SDN-SKE-AkLLNREQTDEWKGWMQLVILIYHISGASAFIPVYMHVRVLVAAYLFQTGYGHFSFFWLKGDFG 522  Nile tilapia

Q6CDI8        493 LKRATSVLFRMNFLSILLAYVMDTDYLFYYFAPLVSFWFCVVWITFRVL--PSWNSIDtsv------------------g 552  Yarrowia lipo...
XP_002127948  473 VHRVFGVMFRLNFLTVMLCLTMDRSYQFYYFVPMCSFWFLVLYLFMALW--PRAYMVAtnkettlsdgetkevtftspif 550  vase tunicate
XP_009029734  443 FHRLCTVLVRFNLLVVLLCLSMNRPYQFYYFVPLVTFWFIVIFIVMALP--PRSSSSmsis----------------sff 504  Helobdella ro...
XP_004347694  656 ITRIIQVLTRLNVLTIGLCMVMDKPYQFYYFVPLSSFWFLVVYAIMAFPsiPAVQKRFpg-------------------l 716  Capsaspora ow...
XP_007803518  399 LQRIVSVLVRLNLLSCLLAYVMRTDYNFYYFPALSSFWFLVVYLTIRVHhqPNVVPRV---------------------- 456  Endocarpon pu...
EPT04032      497 FSRIAQVMIRLNFLTLLLAYTMNTDYISYYFAPLVSWWFLIIYGTMV----PGSQYNDrt-------------------a 553  Fomitopsis pi...
XP_006011687  489 LYRLCQILFRLNFLVVVLCLVMDRPYQFYYFVPLVTFWFVVIYVVFALW--PPIVNRTasgsc-------------fwnl 553  coelacanth
XP_014201210  418 IHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALW--PQIIQKKangnc-------------fwhf 482  pygmy chimpanzee
XP_012821059  417 IYRISQVLFRLNFLVVVLCVVMDRPYQFYYFVPLVTFWFMFIYATMAVW--PQILQKTanans-------------lwnc 481  western clawe...
XP_019206070  523 LYRVCQVLFRLNFLVLVLCVVMDRPYQFYYFVPLVTFWFVVIYTTMAIW--PQILQKTanssg-------------vwhf 587  Nile tilapia

Q6CDI8        553 pVLAKISASAVILNILVRFQL------------PFQIVFAV--LKYLF-N-IQWNLREWRFRLILDIYIVYIGMFAAVAT 616  Yarrowia lipo...
XP_002127948  551 vMCAKLSLLLFTIVLVFLSQE------------LFESMFSWwpVIRLF-ElPPGMVREWWFRCHLDRFAMLHGAVFAFGY 617  vase tunicate
XP_009029734  505 wIFLKIVGLAVVVTLLYSSEV------------FFDQLFLStsLKPLFvT-SDESIHDWRFRWNLDRYSSIYGLLFALAL 571  Helobdella ro...
XP_004347694  717 dAPARILALFTICSIVWLPFSgnykstsaddfpIFQFLFDWwpIKELF-S-VSDSLYEWRFRSGLDCFIVAHGMLIAYAY 794  Capsaspora ow...
XP_007803518  457 -LVLKVFVSVIVVQLLLHTPG------------VLEFVFEL--LQKTC-K-VNVDVHELRFRLSLDAYVVYIGMFTAILH 519  Endocarpon pu...
EPT04032      554 fVLVKILLSMTLVTWFMSEHW------------ILEAIFDF--LSRTC-G-IHWSAREWAFRVNLDLWIVYFGMLAALAV 617  Fomitopsis pi...
XP_006011687  554 sLLLRLGLLLTCICILAYFQS------------TFEAVFATwpVSKLF-E-LQGSVHEWWFRWKLDRFAVFHGMMFAFLY 619  coelacanth
XP_014201210  483 gLLLKLGFLLLFICFLAYSQG------------AFEKIFSLwpLSKCF-E-LKGNVYEWWFRWRLDRYVVFHGMLFAFIY 548  pygmy chimpanzee
XP_012821059  482 gLIIKLTFALLCIIFLSYSQG------------AFENVFSLwpLSKLF-E-LNGNVYEWWFRWKLDRFAVIYGMAFAFIY 547  western clawe...
XP_019206070  588 gVLAKLLGLLIFICFFAFSQG------------IFERVFSVwpISKLF-E-LNGSIHEWWFRWKLDRFAVIHGMVFAFIY 653  Nile tilapia

Q6CDI8        617 LRYKQGNFPLK-----------------------NLvTN------------RLVLGVVALITFIVYIAVAASFGIKQNYN 661  Yarrowia lipo...
XP_002127948  618 IILKRLSIVDDsrqg----------------cllST-KV------------SLIAVTASILCTLFYSVWALQCSDKQSCN 668  vase tunicate
XP_009029734  572 VMAKRFKLIDDsvsd----------------lvaSR-KV------------NMLSMALSICGLVGYAVFTSLCNSKEQCN 622  Helobdella ro...
XP_004347694  795 QIAKSHGVIHDnqpavrpgttppppgpllsgllfNT-AT------------SAILSIVSIGIFCWYIMFTRSCTDKAYCN 861  Capsaspora ow...
XP_007803518  520 LQITggl-------------------------pcST-TClatqikkiptaaHVSAICASGVIVPTYLVLIQKFPDKYAYN 573  Endocarpon pu...
EPT04032      618 IKIREHRLTDHp---------------------qWPlAV------------KGAIGASC-VVLLWFFAFELYQPDKFAYN 663  Fomitopsis pi...
XP_006011687  620 LTLQKWQVFSEgnge----------------plfSH-MV------------SYCLLFVSVVSFLSYSIWAANCKIKAECN 670  coelacanth
XP_014201210  549 LALQKRQILSEgkge----------------plfSN-KI------------SNFLLFISVVSFLTYSIWASSCKNKAECN 599  pygmy chimpanzee
XP_012821059  548 LWLQKHQVLFEgkge----------------alfST-KV------------SSVLLFFSVVSFFTYSIWASSCKNKSECN 598  western clawe...
XP_019206070  654 LVLQKRQVLSEgkge----------------alfSA-KI------------SNFLLFLSVVSFITYSIWASSCKTKTECN 704  Nile tilapia

Q6CDI8        662 QAHPYISWMPIVAFVILRNITVRFRSHYSTWMSFIGTCSLETFTLQFHFFLAADTKGRLYILnTPtssgVlgmlqK---- 737  Yarrowia lipo...
XP_002127948  669 EVHSFASLIPISAFILIRNIPGYLRAGYSSFFAWFGKISLELFIGQYHIWLAADTKGILVITsPQ----W-----P---- 735  vase tunicate
XP_009029734  623 NNNNK----KILSYICLRNMMGCARRKFSAFFAWFGKMSLELFIAQYHIWLAADTHGILVLI-PS----Y-----P---- 684  Helobdella ro...
XP_004347694  862 YIHTFSSPFLVAAFAFLRNLTGRSRAVYSRFFAYIGQLSLELFLLQFHIWLAADTKGILVLI-PGtsgfW-----R---- 931  Capsaspora ow...
XP_007803518  574 WWHPMISPMPIAAFAILRNATQPLRDFHSGLFAWLGRFSLETFILQYHIWLAADTKGLLSLG-LS----S-----Rdavv 643  Endocarpon pu...
EPT04032      664 AWHPYMSFLPVGAFVVLRNANVVLRSASSRAFAWIGACSLETFIIQYHFWLAGDTKGVLLII-PGt--rW-----R---- 731  Fomitopsis pi...
XP_006011687  671 EWHPYISVIQILAFVLIRNIPGYARSVYSTFFAWFGKISLELFICQYHIWLAADTRGILVLI-PG----N-----P---- 736  coelacanth
XP_014201210  600 ELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLI-PG----N-----P---- 665  pygmy chimpanzee
XP_012821059  599 EMHPSISVVQILSFVLIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTKGILVLI-PG----N-----P---- 664  western clawe...
XP_019206070  705 EMHPYISVVQILAFILIRNIPGYARSIYSSFFAWFGKISLELFICQYHIWLAADTKGILVLI-PG----N-----P---- 770  Nile tilapia

Q6CDI8        738 ----------YLNFGLVTVIFIIVSHAVAEQSNALTKLFVGNQDQQLPEHV 778  Yarrowia lipolytica
XP_002127948  736 ----------MLNLLVSTFVFVCVAHEISALTGTFAKYLVGPAKTADTKTV 776  vase tunicate
XP_009029734  685 ----------VMNLIVTSFVFVCVAHEIKLLTSLLTPVLVPRSRLKLARNV 725  Helobdella robusta
XP_004347694  932 ----------LLNAAFTTGLFVAVSEVASDSSALIVSLLAPGDNTRAVISR 972  Capsaspora owczarzaki ATCC 30864
XP_007803518  644 gtewidklglLCDFTLVTAFFLWVSWAVSHATNVVTSFIVNGQQPTKAPNL 694  Endocarpon pusillum Z07020
EPT04032      732 ----------PVNLVLTTIVFIYVSHRVAQATGEITNWMCGTVKAQSLPTv 772  Fomitopsis pinicola FP-58527 SS1
XP_006011687  737 ----------VLNIIISTFIFVCIAHEISKITNDLVQIAIPKDDTALLKRL 777  coelacanth
XP_014201210  666 ----------MLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRL 706  pygmy chimpanzee
XP_012821059  665 ----------MLNIIISTFIFVCVAHEISLITNDLAQIVVPKESSALTKRL 705  western clawed frog
XP_019206070  771 ----------SLNILVSTFIFVCVAHEISLITNDLAQVVIPKDSMALLKRL 811  Nile tilapia
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