Conserved Protein Domain Family
PACT_coil_coil
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pfam10495: PACT_coil_coil (this model, PSSM-Id:313676 is obsolete and has been replaced by 463115)
Pericentrin-AKAP-450 domain of centrosomal targeting protein
This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly.
Links
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Statistics
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PSSM-Id: 313676
Aligned: 99 rows
Threshold Bit Score: 51.4364
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0U842         989 SRAEGFREALSYQKRFFLMQIQVYSECNQQDLNLISQMGITP-----DITIHERRPRLKSAALAVIAAIRMQKLSEGW 1061 Parastagonospo...
57_pfamImport    3 TREALFRDHLGYQKQYLLTILSQFEKSEQRILVSISRIGYPV-----PSSKAKKFNKFKTVACLAIFISRAQRASAAW 75  
5_pfamImport     3 TRESSFREDLAYQKNYLLELLGRSEKSERKIYASIARIGFPV-----APSQPKLGRRLKSIAHLIVFVNRTQKGSSEW 75  
6_pfamImport     3 VREACFRDGLVYQKKYLLELLGKYEKSERTIFASIARIGFPVa---vAPPATKKAPKLKSVAMMVVFLSRVKWVS--- 74  
56_pfamImport    3 TRESGLRSDLGYQKQYLLVLLARCERNEQKILAAIAKTGFPGtlphtSAKSTRKGRKLKTVVHSIVFALRAKHASDAW 80  
39_pfamImport    3 TRENTLRQHLAHQKEYLLTLLSKLQQDDLPILKSLAHTQRSP--------KGAPVKRLRSIVHTVMFLNRAKKAAERW 72  
16_pfamImport    3 TRESTLRGELAHQKRYLLVLLGKFEKSERTIISAIAQIGFTDap--pEEVKRPRVQSVKSAALAVIFLARARRASEGW 78  
84_pfamImport    3 TRESILRFDLAYQKQYLLVLLAQFEKSEQTIFAAIARLGFPEl----PAPSFRKRRKLKSIGLLVVFLARIRRASAEW 76  
40_pfamImport    3 LREGQFRDDLRLQKEYLQTQLEREQVKIDTTSLTLQRFGLPLl---aSNEPEERVPRLKSVAVLVLSTIRLQRMAADW 77  
83_pfamImport    3 SRELAFRNDLTYQKEYLQAMVKDKQAIIDLVMSQLGLPPSSPp---sDHRPGGSRPTLKAAVLALISLRRMSRASQQW 77
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