Conserved Protein Domain Family
TMEM132D_N
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pfam15705: TMEM132D_N (this model, PSSM-Id:318006 is obsolete and has been replaced by 464813)
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Links
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Statistics
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PSSM-Id: 318006
Aligned: 48 rows
Threshold Bit Score: 102.698
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6IEE7         45 VSYRLSHTRLAFFLREARpPSPAVANSS------LQRSEPFVVFQ----TK--ELPVLNVSLGPFSTSQVVARELLQPSS 112  human
XP_015221913   49 VSYQITNANSFFFLKEIS-QDIMRNSSM------QIHTEPFVILK----TS--QPPVISASYGPLSVEQTVPLHFMQTAD 115  spotted gar
CAF94499       28 VSYEVRDAD-YLFLKEAG-QDIMRNCSM------QSHTQPLVILK----AS--AQPAVSASYGTMSTEQLVPRDLVRSVQ 93   spotted green...
XP_007668804   60 ASLEPLDVPEFFRLQRTG-HYPPANASL------DSRTETFLFLR----SRpaARPLLRASYPPFTAQQEVPGRTPEPS- 127  platypus
XP_002594816    7 AHLTYEHADSAYFLQDDF-SSLFSNGSE------TVQIDQFALLR----PR--EPAVVRASYGPFKVQQSVPHEFLFP-G 72   Florida lancelet
XP_002942160   28 VSIEVKDVPQYFRLQRAA---PGEESVPthgniaQSHSETFIVTRl---GS--REPHVRASYQHLQVQENVPWN-KLGAR 98   western clawe...
XP_015827920   60 VSYEVQDAD-YLFLKEAG-QDFMRNSSM------QSHTQPFVILR----AS--RQPAVSASYGAMYTERLVPLDLVQSVQ 125  turquoise kil...
BAC33373       44 VALELLDAPEHFRVQQVG-HYPPANSSL------ASRSETFLLMQp--wPR--AQPLLRASYPPFATQQVVPPRVTE--- 109  house mouse
XP_010709076  316 VEMELQEVPEHYRLQRAD-GVLPANTSL------HARSDTFLLLPrhptAG--PSPLLRASYPPFSTHQ-------E--- 376  turkey
XP_008114048   34 AELKVLNGPEYFRLQRTD-RYLPGNASL------SSRSETFLFLHr--qLT--GKPTIQATYQPFTAQQVVPTDDSQ--- 99   green anole

Q6IEE7        113 TLDIPERLTVNWKVRAFIVRSHVPASQPVVQVLFYVAGRDWD---DFGVTERLPCVRLHAFRDARE 175  human
XP_015221913  116 LFRTSTKFTFDWKIQSYILTQKVYSSTPKMRILFYISGRDWEaqgTEGAMDDLPCVIVYAFWQTQE 181  spotted gar
CAF94499       94 LFNAPEDFTFNWKIQAFILTPRVFSSKPKVRVLFYVAGRDWSr--EEGPGDQLPCVTVYAFWQTQE 157  spotted green pufferfish
XP_007668804  128 ------GFSADWDVRAVSVEASVSPAEPQARVLFHLKGQDW-----LSGHGGLPCARLHATHPAgs 182  platypus
XP_002594816   73 LNRTSPGQFYKLDIRAHLLDKSLTPEKSRLGVLFHIVESDLS---RNEGSGPLPCIVLHVTMDGKE 135  Florida lancelet
XP_002942160   99 IRG----------VQGEVVGDEVSPSDPVTRILFHRSGVDGQ-----ARGAQNTCVNVRGTYDGvn 149  western clawed frog
XP_015827920  126 LFNAPGVFTFNWKIQAFVLTPRVFSSKPKVRVLFYVAGRDWSk--GESAEDELPCVTVYAFWQTQE 189  turquoise killifish
BAC33373      110 ----PHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWP-----PGPGSLPCARLHATHPAGT 166  house mouse
XP_010709076  377 ----VPTKSPTWAIRAVPLHSTVSPDEPNARVLFHLHGPDWRgrrDPPGDHSLPCIVLQAQQRSQT 438  turkey
XP_008114048  100 ----STDTSVTWDVRAVSIEGTVSPYEPYTRVLFHLQGQDWM-----SEKKPLPCVTLYVFHQAQV 156  green anole
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