3II6,2E2W,1Z56


Conserved Protein Domain Family
BRCT_DNA_ligase_IV_rpt1
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cd17722: BRCT_DNA_ligase_IV_rpt1 
first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the first one.
Links
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Statistics
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PSSM-Id: 349354
Aligned: 20 rows
Threshold Bit Score: 93.5183
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [SC]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
3II6_X         10 IFEDVEFCVMSGTDsq-----pKPDLENRIAEFGGYIVQNPgp------dTYCVIAGSEn--iRVKNIILSn-KHDVVKP 75   human
1Z56_C         10 LFYVLSDYVTEDTGir----itRAELEKTIVEHGGKLIYNVilkrhsigdVRLISCKTTt---ECKALIDR--GYDILHP 80   baker's yeast
Q6C8A3        704 VFKATSFAVLSDMSspr--ymsKAAVENLIKKHGGTVFQTVeg-----phTIPVADTRTi---KVQALTKRvhGVDVIRP 773  Yarrowia lipo...
Q1DKE7        715 VFEGMNFFVITDSVepe--kksKLELEQLIKANGGKIYQTHtaa----pnTLCIAERRTv---KVASVQKVa-KESIIRP 784  Coccidioides ...
Q2U6A1        722 IFEGLNFYITTDSNtpv--kksKAELEQLVKANGGKFFQTSnaa----psTICIADRRTv---KAASLQKSg-NVNIIRP 791  Aspergillus o...
Q0UCI9        732 IFDGLSFYIMTEQLhpt--kksKVDLEALVKANGGRVVQRDsme----pnLVIVADKRLi---KVASLEKRd-TNNIVKP 801  Phaeosphaeria...
XP_001595253  581 VFEGMDFCILSDMIlpv--kksKAELETIIKNNGGRIYQSPsa-----keDIIVIADKRv--vKVASLIKSg-KINIVKP 650  Sclerotinia s...
P0CN09        692 SDADVETSIFSDMT--------FSDLEALVHKHGADFTQAQls-----dlSAIVISPDQkn-pLVRAQIRH--GVNVIKP 755  Cryptococcus ...
P52496        677 LFSGIEFLIMSDKReadgevttIEEMKAMVKQYGGKIVNSVdla---tnyQIMVITEREl---PVSSQYLSk-GIDLVKP 749  Candida albic...
Q7Z7W5        671 IFNGMKFVVFSDPKsrtg-eadKKELMKTIHANGGTCSQIVnk-----nsEAIVIYGGSitpyDLKLVIDKg-IHDVIKP 743  Coprinopsis c...

Feature 1          #   #                          
3II6_X         76 AWLLECFKt----------kSFVPWQPRFMIH 97   human
1Z56_C         81 NWVLDCIAy----------kRLILIEPNYCFN 102  baker's yeast
Q6C8A3        774 NWLLDCINe----------eKLVALEPRNLLE 795  Yarrowia lipolytica
Q1DKE7        785 SWLFDCIKqnevd--kglpdLLIPFEPRHMYF 814  Coccidioides immitis
Q2U6A1        792 SWILDCIRqseid--aglpdSLLPLEPRHVFF 821  Aspergillus oryzae RIB40
Q0UCI9        802 VWIQDTIQqnevd--ngalpYLLPFEPNRHMF 831  Phaeosphaeria nodorum
XP_001595253  651 QWVLHAVAqmeidaklgrsrFVIPYETGHMLF 682  Sclerotinia sclerotiorum 1980
P0CN09        756 EWVFESIAr----------rTALPFLKEFLVF 777  Cryptococcus neoformans var. neoformans JEC21
P52496        750 IWIYECIKr----------gCVLQLEPYFIFA 771  Candida albicans SC5314
Q7Z7W5        744 SWITDSVTl----------gEPAPFKKKYFFH 765  Coprinopsis cinerea

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