Conserved Protein Domain Family
SpoU-like_RNMTL1
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cd18106: SpoU-like_RNMTL1 
SAM-dependent rRNA methylase related to RNMTL1
RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349979
Aligned: 17 rows
Threshold Bit Score: 186.303
Created: 14-Jan-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative SAMputative dimer
Feature 1:putative SAM binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other SPOUT methylases
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
BAD96620      210 LLLICDNLRDPGNLGTILRSAAGAGcSKVLLTKGCvDVWEPKVLRAGMGAHFRMPIINNleWETVPNYLPpd-------- 281  human
EEB19141      158 LTIICDNIREPGNLGSILRVAGAVGcKKVIMTTGCvDLWNAKVIRSAAGIHFRLPISSNveWDDIDKQIPdd-------- 229  human body louse
XP_001949552  194 ITVICDNIREPGNLGAVLRTVTAVGaSQVILMKGCtNLWGDKVLRAGCGAHFRMKIISDvsWSFLENIKG---------- 263  pea aphid
XP_001633990   91 LTVICDRVKDPSNLGTIVRTCAAAGcQALITTEYStDLWDPKVLRGGAGGHFRVPLYGLlsWKQIADMLGdd-------- 162  starlet sea a...
AAL48701      215 ITVVCDNIREPNNLGSIIRTCAALPcSQVVVTHGCcDPWESKALRGGCGGQFRVPIRDDvtWDELALTIPpeaa------ 288  fruit fly
EZA55946      204 LTIICDNIREPGNLGTIIRAAAAVGcERLLLMKGCvDLWDPKVLRSAVGAHFRLPISKNlsWNEIPSLIKee-------- 275  Cerapachys biroi
EAA08963      283 VTVVCDNIREPNNLGSIVRSCAAVSvREVILLKGCaHPWDLKCLRGGAGAHFRVPIYGPieAYQLPEHVRag-------- 354  Anopheles gam...
EFX74184      252 LTIICDNIRDPGNMGTIIRCAAAVGcKALITTPDCvDVWDSKVLRAAAGAHFRIKLALSvdWDLIAENFVtq-------- 323  common water ...
KFD57435      509 LIVVCDGIKDPSNMGSLIRSLASAGcRAMYTLAGCcDPWQVKVLRAGSGGHFYLPVYERlhLEDIRSYLPse-------- 580  pig whipworm
KER31196      205 ATLVLNGIRDPGNMGSLLRTAASFGlSSVLVSEGSvDIWNEKVIRAGMSSHFRIPVYQNlsWREIGERLAdeaaqflgts 284  Opisthorchis ...

Feature 1                  # #                                                                    
BAD96620      282 ----tRVYVADNCglyaqaemsnkasdhgwvcdqrv----------------------------------mkfhkyeeee 323  human
EEB19141      230 ----sQIILADNRtlcddnstdssivenqdgdeyvsdedsde----------------------nddsssddenessvkk 283  human body louse
XP_001949552  264 -----QVCLADNNyvgnidysninen------------------------------------------------------ 284  pea aphid
XP_001633990  163 ----tRLYLAESDntgkiiispwkyfvve------------------------------------------------npi 190  starlet sea a...
AAL48701      289 --ddcHVFIAETNqrk---------------------------------------------------------------- 302  fruit fly
EZA55946      276 ----aKIFLADNNitsvvn------------------------------------------------------------- 290  Cerapachys biroi
EAA08963      355 ----sIFVVADNKkptd--------------------------------------------------------------- 367  Anopheles gam...
EFX74184      324 ---ddTVLLADSSiqpaspivdekdrlasnlswiereqgpksk--------------------sveilkegdiqyrdssy 380  common water ...
KFD57435      581 ----fTLLLADAHstnassvs----------------------------------------------------------- 597  pig whipworm
KER31196      285 ggnnvKVFVADVAseetekriaecskieavatqavgsdidleddseetfeatfpasfrsfvsdpatatayrlplpsaphf 364  Opisthorchis ...

Feature 1                                          ####  #                            ## #     ## 
BAD96620      324 dvetgasqdwlphVEVQSYDSDWTe--aPAAVVIGGETyGVSLESLQlaes-----------tggkRLLIPVVpgvDSLN 390  human
EEB19141      284 nslcrsdniddynLPLLNYNDVNYsn-nSIVIIIGGESyGISEDAYKfger-----------rkglRVTIPLLnnvDSLN 351  human body louse
XP_001949552  285 tnvnvfrktapieLPIAPYYEIDYckitPLILIIGGEThGLSDEGYEfars-----------rkgiRLNIPLEngiESLN 353  pea aphid
XP_001633990  191 swhcygtlnldlgSIIIPYFEVDWtl-gPSALIVGGETtGISTEAQMlacg-----------ergqAVHIPMVgniDSLS 258  starlet sea a...
AAL48701      303 ----------renNQTIDYADIKGlg-aHNLLIIGGEShGVSEEAYRflnlv---------ggkgkCIYIPLAagiDSLN 362  fruit fly
EZA55946      291 --------kimsqFPVVPYYTLDFtk-rEAIFVIGGETeGVSLNACKflrd-----------rnctRVNVPLTngvDSLN 350  Cerapachys biroi
EAA08963      368 ---------erngFRWKHYDRIDYgsadHVVLVIGGETyGVSDDIRSlihqltqndgeqapqdrkfVAHIPLAngvESLN 438  Anopheles gam...
EFX74184      381 lddkslrvykklpLPHSAYDKIDLnsvtSLTLVIGGEThGLSSAAHKlahe-----------ygglKVFIPLEnkvDSLN 449  common water ...
KFD57435      598 ------ndtdseiSVVHWSSAIRMssevPVVLFIGSESsGLSKATVRlave-----------lkgsRLHIPMAqkgMCLN 660  pig whipworm
KER31196      365 risyfsagppvdeTPSCKLPSEKId--fKPVLVVGSEVeGLSPEAYYlahl-----------tggsRIVIPSSpdtESLN 431  Opisthorchis ...

Feature 1         #  #        
BAD96620      391 SAMAASILLFEG 402  human
EEB19141      352 SSVALVECVKNN 363  human body louse
XP_001949552  354 SATAVGILCFEA 365  pea aphid
XP_001633990  259 AGISVALIVYEA 270  starlet sea anemone
AAL48701      363 VASALTLLLFEL 374  fruit fly
EZA55946      351 VGVAVGIVTFEM 362  Cerapachys biroi
EAA08963      439 TASALSVILYEM 450  Anopheles gambiae str. PEST
EFX74184      450 AGVAVGILAYEF 461  common water flea
KFD57435      661 SSVAAAVMAFEI 672  pig whipworm
KER31196      432 VLAATSTILGEM 443  Opisthorchis viverrini

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