Conserved Protein Domain Family
MRG
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pfam05712: MRG (this model, PSSM-Id:368575 is obsolete and has been replaced by 461721)
MRG
This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.
Links
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Statistics
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PSSM-Id: 368575
Aligned: 59 rows
Threshold Bit Score: 115.014
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EGT42131            100 KNRESilp--ipSSSSIEERWHWK----LDIPSGLKKIISEDQRLI-KEGRLSKI-----PSQISVEEIFNQYLESLKId 167 Caenorha...
CAP33940            108 TTKKS-------TKRKRFPYPTVSt--nFELPPALATMLVDDYTAI-RKGFVSKI-----PAEHSIDRIITDYIKTLPAk 172 Caenorha...
EFO83368            119 GGRSS-------KKDKEDSTPYTAvpmvVHLTSPLKKILIDD-NVLnNKGYITKI-----PAKFTIDQIITDYIKTIPVt 185 Caenorha...
EFO91958             98 QSEESd-----eSSDMESPTPGIR----FDMASPLKKIIIDDSKYL-KSDVLTHV-----PAAFSIDEIVSDYLETIPVt 162 Caenorha...
EFP09888            487 GRRASpg----pSTSSQAQRPKIV----VDFPIWMKGIIGHDTREFlHNQTTNKLvvrlqPEGRTVDDIIKDYTDSIGVs 558 Caenorha...
EGD77021             89 RASTS-------SASPSGGAQRSS----LSVPPSLSRNLVLQ-HLRhADRMLIPL-----PRRPSVHEILSRFRHHDIDa 151 Salpingo...
CDS30678            160 RRNRStaktageTDEGLLQRSQIN----VKLTDSLKAFLADDWDLVtKQSRIVNL-----PSRKPVKTVIEEYLEYSKSk 230 Hymenole...
WGS:AAPU:GI12047-PA 215 KDTHT-------TDAEKRVHPEDRv--mLRISERLREYMEYDYNMVcKLGKEHDL-----PARMPIITILENFVKQRAVe 280 Drosophi...
WGS:AANI:GJ13317-PB 188 KQRDKskg-gdkNDDEKRIHQEDRv--mLRISERLREYMEYDYNMVcKLEKQHAL-----PARTPIVTILENFVKQRAVe 259 Drosophi...
XP_015839666        134 GVTSS-------SEDDSSIEEEtv---pIELTPELRACLEQDYCLInTKNKLVKL-----PAEPNVVTILENYWRHYANg 198 red flou...

EGT42131            168 rkg------------------------pktG--DEQLT-QHHIEMVIDYFNLYFRS--KILNKAEKCQFKELRKEQRRG- 217 Caenorha...
CAP33940            173 nadlenidd-----------vvieydstdiR--ITNLAmICTARGVADYFNAVCGSsvQLLYHQERHQHLELIrmkalem 239 Caenorha...
EFO83368            186 kdqlqnvdd-----------vvleydsrdvS--NLALV--CTARALVDYFNVIIGY--HLLYKIEREQFHDLVKQKSKGr 248 Caenorha...
EFO91958            163 dqelqevnq-----------vnftvtedepT--PNSVL-AISAQSLVQFFDVVLGF--HLLYPNERKQYNDLIhkvaide 226 Caenorha...
EFP09888            559 dedvermdd-----------dmldynddgtS--LDNLSlAHCAKTLKNYFNRLFGR--RILYNSEREEHDTLVRVYAYRk 623 Caenorha...
EGD77021            152 kddt------------------------------rrqqeEEFCANMEVVFSTALGQ--RLLWSIERAQYMHWLKKRDALp 199 Salpingo...
CDS30678            231 plptd--------------------htaykI--TQEYR-EEFVKGIKTNFNCIAGS--QLLYKFERPQYGQLMRNN---- 281 Hymenole...
WGS:AAPU:GI12047-PA 281 laigikqdssrarntqsrnarmereydrvmS--NVCML-KEVVDGLRIYFEFHLED--HLLYKEERDYVLSKL-----Hd 350 Drosophi...
WGS:AANI:GJ13317-PB 260 laigikqdssrarn--tlsrnarmereydrVmsIVCML-KEVVDGLRIYFEFHLED--HLLYREEKDYALGFLTDNNMkn 334 Drosophi...
XP_015839666        199 qisdlnektsqrhr-ypfnntqrrrpedvqR--NLNIC-SEVLDGIRLYFDYTVND--LLLYKCEQGQIE--------Tk 264 red flou...

EGT42131                --------------------------------------------------------------------------------     Caenorha...
CAP33940            240 nlp----------------------------------------------------------------------------- 242 Caenorha...
EFO83368            249 nysvg--------------------------------------------------------------------------- 253 Caenorha...
EFO91958            227 glv----------------------------------------------------------------------------- 229 Caenorha...
EFP09888            624 klrygd-------------------------------------------------------------------------- 629 Caenorha...
EGD77021            200 v------------------------------------------------------------------------------- 200 Salpingo...
CDS30678                --------------------------------------------------------------------------------     Hymenole...
WGS:AAPU:GI12047-PA 351 dismysnklaaqakeyinpsmdnelismdgsmngtnggdgtilggieyekqlqkcllyivkcsgknnmahaydqrtspyt 430 Drosophi...
WGS:AANI:GJ13317-PB 335 cslllnksyefinpsgdnelismagnvngtngvdgpllgdieyen-----------------qlqkclryieknsaknni 397 Drosophi...
XP_015839666        265 qavytsihldkevsssknevsymdyitypnnhddyqngnrqamqrkrs------------lrsnkstdavsngnsqdsak 332 red flou...

EGT42131            218 -----------------------------QSKFLPSEHYGLIHLARSFAVIPDAL-----ELKLEDEKHFKNITPVVHNF 263 Caenorha...
CAP33940            243 --------------------ahaatntvvDRGFRHSQEYGIIHLVRLLSKLPELL-----AHTDWEHRILSRIMTGIRDL 297 Caenorha...
EFO83368            254 -----------------------tvatmpDNGFRASSEYGFIHLLRMMAKLPDLL-----KLTQWNAHLCNRIMIGVHDF 305 Caenorha...
EFO91958            230 --------------------llnpnnlpaPAGFKSSEHYGLIHFLRMFTKLPKLL-----EESGLNQNVINRLTIGIESL 284 Caenorha...
EFP09888            630 -----------------------vvtdpfQYGFHASKRYGIVHFARMLSRFDNLI-----ESLRLHDAMILYLNLGIKDL 681 Caenorha...
EGD77021            201 ----------------------------dDQVTFFARIYGAEHFLRLIVLMPELLrvcvpANMPIFQREHAVF---LREL 249 Salpingo...
CDS30678            282 ------------------------------ENKEMIELYGPVHLLRFLLKLKDII-----TFLKNDRTSLGLMEALAADL 326 Hymenole...
WGS:AAPU:GI12047-PA 431 aayklpmemrgflcetfswsllaktdtlyLDRSEKSMIFGAPHLARMLVLLPAWL-----NESPISNEKLEILIPHLNSL 505 Drosophi...
WGS:AANI:GJ13317-PB 398 alaytaayklpmemrgflretfswsllseESPPEKSIIFGAPHLARMLVLLPECL-----NASPISNEKLVDLLPHLDSF 472 Drosophi...
XP_015839666        333 akasssvdnndscgsrplslrllpehvynQQPPPPCLVYGAIHLTRLFVKLPELL-----NAATIDEKKWTTLLQHMDTF 407 red flou...

EGT42131            264 MEWLDNNKEMFYNkVRSYLK 283 Caenorhabditis brenneri
CAP33940            298 VGFLDKNRSHYHKgAEMYES 317 Caenorhabditis briggsae
EFO83368            306 VVFLNKNHAQYYGdRDDYET 325 Caenorhabditis remanei
EFO91958            285 LDFLERNFEKYYNnGVDYDS 304 Caenorhabditis remanei
EFP09888            682 MEFLGNNVGRYYDrDADYVP 701 Caenorhabditis remanei
EGD77021            250 IEFMNGHQDELFT--PTYQP 267 Salpingoeca rosetta
CDS30678            327 VEFLDINRKEYFS-LEDYVG 345 Hymenolepis microstoma
WGS:AAPU:GI12047-PA 506 INYLEN-HKEWFD-KQNYCK 523 Drosophila mojavensis
WGS:AANI:GJ13317-PB 473 INYLEN-HKEWFD-KQNYVD 490 Drosophila virilis
XP_015839666        408 IDYLNE-HREWFG-EKFYID 425 red flour beetle
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