Conserved Protein Domain Family
Ax_dynein_light
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pfam10211: Ax_dynein_light (this model, PSSM-Id:370886 is obsolete and has been replaced by 463000)
Axonemal dynein light chain
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Links
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Statistics
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PSSM-Id: 370886
Aligned: 88 rows
Threshold Bit Score: 87.992
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ETO09616      54 QQILNSILPllPIE------GK-EYCFR-QveflFVSSAVPTRKDVTRLQQDwne---mlqLRQARETGI-CAIRRktik 121 Reticulomyxa fi...
GAA47226      20 lqALSKFFP--PVRy----kEM-GTKWV-K----HVSAKQATPIEMTHVKQEvdr---vlkVRCSRKAPL-CVIRE---- 79  Clonorchis sine...
CAM68828     268 SRVLSSATAaaARSa-------aSTPVMwR----RADVAHLSRLDVVLLYKHler---rcaCESARPRGVvCPNRE---- 329 Leishmania infa...
Q4DXE3       141 RNTFCS-----TREf-------gESKWM-K----VAAIDHTSRLDCVHLQDHlnr---rckEENARPSGVlCTIRE---- 196 Trypanosoma cruzi
Q4DPW6       146 ERVLYTLLP--PRRtv--ckET-GNTIL-Q----CVSTEPSSRVEVADLHERlte---rlrQRRARDSGI-CPIRR---- 207 Trypanosoma cruzi
XP_003246751  44 NKVFEYIYP--PEEw----mED-GVKWR-R----VASTEPADRNHVLALAEDlks---nlsYWHARMHGV-CLVRR---- 103 pea aphid
XP_003247366  41 kSILEEIFP--PRVwtrivnNNnKVITLrQ----TISREPSNRDGVQKMIVMlnh---leqFFRFKKKGI-CEIRN---- 106 pea aphid
CZT99740      80 ffnLSLLFP--IKVf----kKT-DKTLI------QLISEDTNLSDL----ELiqa--------------vlkNIENnnmd 128 Plasmodium falc...
EDL47025      68 NEPLYNMFP--LKCv----rDK-KVDQI------SYVCRVTSEEDATACLKKiqdivskmyAQNM-------LIEK---- 123 malaria parasit...
EAY21294      42 RDVLNSLFP--PIEf----eQD-EIKYT-R----SISTAPISKTDVTKLRTEldt---llhKNKTKPKGI-DIIRS---- 101 Trichomonas vag...

ETO09616     122 tkhvakreQLNNQALD---ELIRQLTIiMPEQGLLAVRIKNEANMTVDSYQTLYHSSIAYGMRKCI--NTE----DeTSI 192 Reticulomyxa fi...
GAA47226      80 --------DVLSDLIR---EILRQVTIdCPEQGLLLRRILDHNEMEFNAYETLLRFTDAFVGRKWA--EWQ----HwKAD 142 Clonorchis sine...
CAM68828     330 --------CIYNDGLR---ELIRQVTLlCPERGLLLDELARRMRQAIETYDVLLDSANQYAVRKST--ERD----LhQYL 392 Leishmania infa...
Q4DXE3       197 --------GIYTDGLR---ELIRQTTVlCPERGLLLAELATEMQQTTNKYDILFDSASQYAVRKAI--ERD----MrSYL 259 Trypanosoma cruzi
Q4DPW6       208 --------EVYAEVFD---ELIRQITLeEPTRGILLLRIRDELYQTLAAHSSLAERAMYFASKQRE--EAG----EgMDE 270 Trypanosoma cruzi
XP_003246751 104 --------ELYTQCFN---ELIRQVCVnSIDRGQLLIKIRNEYNASIKAHKLLFESGLIFRIKHTT--LDD----HkDDV 166 pea aphid
XP_003247366 107 --------SVHNLFFD---EVLRQVIImDEDLGAILFRIHNEFKNMIFILKCMYDKAV-------LtnNSN----RdSSN 164 pea aphid
CZT99740     129 klnffyveNIIFELLD---EIIRQVICeYPKRGFAVLLITNELQKNINYYKNLID----------IieHNNemntQgFKE 195 Plasmodium falc...
EDL47025     124 --------DFLEDLLSvfmELCRQVSVtCFQRGSLLRQLFNYNSMLLFHYHKLVRSSLTFNLKKEI--KRShtmsElRQE 193 malaria parasit...
EAY21294     102 --------ELYSQCFE---EVIRQVTIdSNARGRLLFRIRNHYKTLIQSYKDLNELALNFGANKNI--QVT----LgMDQ 164 Trichomonas vag...

ETO09616     193 CQNK----VMQARQKKQTLVKQIETlqtkSTDQQRHFNELKRIDTKYQNDDI------------EYLKQQKQALESFLT 255 Reticulomyxa filosa
GAA47226     143 RTRQ----IYELEDTKRILEFQATElkhkVDQLEKKNQEMKIKWDAARMEEV------------KYYKKTGEHLRAQMd 205 Clonorchis sinensis
CAM68828     393 FAEK-----TDLETEVRRREHRVNEwrakYAGLQKRFQEQQEADRKLHAEEI------------AYAKRANQQLVSEIK 454 Leishmania infan...
Q4DXE3       260 FDDK-----KSMESEVRRLENRVNElrakRDGMIKRFEEQKQSEQNRHEEEV------------KYLKKANQQIISEIK 321 Trypanosoma cruzi
Q4DPW6       271 LKRR----IHELEEKRLELIVRKKAvqvrEEQILRAIEQENNTRSKLRQDEL------------GYYRRANRQLTQRIK 333 Trypanosoma cruzi
XP_003246751 167 TEKD----IQDIEDAHVKLKKKLVDannkYNKLKTDLKNELNNLKDANQHEL------------SFFNRNHEALKDQLK 229 pea aphid
XP_003247366 165 IDPE-------LFTEVEELTRINNElkikCRHSKQRHKERLKKKESGEDYKFlvslkmkyemlnNYIKRSTKQLKEQMN 236 pea aphid
CZT99740     196 MNEKnnliLQDLLVEENKLKEKLIDvqtrLELLKEENKKKLQENKNKKEIQY------------DLLKHNESLLDkike 262 Plasmodium falci...
EDL47025     194 MERK--------KEAINSLRSEILDtdrlIEEERANAEREMSEVNIIYQNKI------------DKLKKNNQRKRDEFT 252 malaria parasite...
EAY21294     165 LLDY----NKKLREKRRELELEANNlqiqLDGLEKRIQENKQIREKEFADEI------------AFLKKQGQSIKMIYD 227 Trichomonas vagi...
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