Conserved Protein Domain Family
THRAP3_BCLAF1
?
pfam15440: THRAP3_BCLAF1 (this model, PSSM-Id:373846 is obsolete and has been replaced by 464718)
THRAP3/BCLAF1 family
This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).
Links
?
Statistics
?
PSSM-Id: 373846
Aligned: 31 rows
Threshold Bit Score: 275.484
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_014352806 126 RSRSRSP--KRRSVTPRS-RSCSRNSDRSSSGrsrsSSSGSSshhSRSGS-SKRRSVKQHN-AAQKEARASLPPAQVSQG 200  coelacanth
XP_003466466   3 WSRSRSPewKHRSLSPVP-RNFEYYKQRFSSG----HYGCEY---RKDPTrPNAWRMDDEK-HGQSKTRISPRGNFYHRS 73   Domestic guine...
XP_005998812   3 RSRSRSPrwKRRSKSPAYrRSPEHYRPRPPYD----HHDDDFrgfRKDARrPEPWRGKAGKiQGRNISRTFPHGNMHPKN 78   coelacanth
XP_011234923   3 RSRSRSPrwKHRSLSPVP-RNSDHYKQRYFHG----HYGCEY---RKDPKrPITWRMDSEK-HGQSKPRIPSRGNVHYRS 73   giant panda
XP_005227643   3 RSRSRSPrwRHRSLSPVP-RSSEHYKQRFE------HYGYDY---RKDPKrPITWRMDDEK-YGQSKPRISSHENIQYRS 71   cattle
XP_023609450   3 RSRSRSPrwKHRSLSPIP-RKSENYKQRCSHE----HYCFEY---RKDLKrS-TCRMNDKK-HGQSKPRISSHESAHYRW 72   little brown bat
XP_003203102   3 RSRSRSPrwKQRSLSPAF-RSPEHHRQRHAHV----NYDCEYksfRKDLKkPMTWRTDDEK-YGQSNSRFAPHGNNHQRM 76   turkey
XP_007668532   5 RSRSRSPrwKQRSLSPAF-RSPERYRQRHSHS----GYDCDYkgfRKDPKrPPLWRVDGEK-YGPNDQRVPAHGGAHQRA 78   platypus
XP_023354706  29 RSRSRSPrwKQRSLSPEF-RNTEHYRQRYPHG----NYDYEYkgfRKDPKrTVPWRMDNEK-YEQNDPRISSHGSVHHRI 102  Tasmanian devil
XP_010594053   3 RSRSRSPrwKQRSLSPVP-RNSDHYKQRQFYG----HYDCEY---RKDPKrPIASRMDSEK-YGQSKPRIHCRENEYCRS 73   African savann...

XP_014352806 201 AESKAKppadatsndskdpeaiskpwkgltaydsspkhpssvvhsvnasglnSPP-HPSPiqkspLQSVAVKRSPPQ-KS 278  coelacanth
XP_003466466  74 YEHRSP----------------------------------------------SPN-IRSS-----FDDVYTYKPHRV-HL 100  Domestic guine...
XP_005998812  79 FEHRLP----------------------------------------------LPEvKRMP-----LENFHRPTPQRKhHS 107  coelacanth
XP_011234923  74 YEHRSP----------------------------------------------SPNlRRNS-----LENAYTYKPYRV-RS 101  giant panda
XP_005227643  72 YEHRSP----------------------------------------------SPNiRGNS-----SEKFYTYKPPQV-YL 99   cattle
XP_023609450  73 YEHRSP----------------------------------------------SPD-RRSS-----LDDFYSYQLYQE-YS 99   little brown bat
XP_003203102  77 YERRSP----------------------------------------------SPNlKRIP-----MEDAYSHKPYRT-HS 104  turkey
XP_007668532  79 YEPRSP----------------------------------------------SPAvQGLS-----LEDVYGYKPPRG-YS 106  platypus
XP_023354706 103 YEHRSP----------------------------------------------SPSiRRDC-----LEDTYSYKPHRE-YS 130  Tasmanian devil
XP_010594053  74 YDYRSP----------------------------------------------SPNiRGNS-----SENV--YKLHRV-YS 99   African savann...

XP_014352806 279 PQSH-SPAGPSSLRQSPVPPiPpl-------------rtVPRQSPQAh---SPKRSSPAERSPVRKSPPIISTSYN-NA- 339  coelacanth
XP_003466466 101 PGRG-DSNRRPQYMPTYSEN-Tphleh-------erspyPQKMQGRY----IPNNYNERGRKPPQRSMADSFAFEGkWH- 166  Domestic guine...
XP_005998812 108 PERG-EGSRRKPNFPRRVEG-GsyrehewhpnkiskplpHNKKQECStqeePKADRGMKLGKSFHRPPPVFTKYQEkHHi 185  coelacanth
XP_011234923 102 SERG-DGNRRSNYMPKYSEG-Vpyeeh-------qrncySQKVQGRYipddHRVQRSGKGGKPPQRSIADSSRFEGkWH- 171  giant panda
XP_005227643 100 PERGdDSNRRAQYVPRHSEG-Mfyreh-------qrscyPQKAQGRYipddRRNRRSEKGGTPPVRSTTDSFRFEGhWH- 170  cattle
XP_023609450 100 PRRR-DSSRRSQHMSRYSED-Vpyeey--------cwdyPEEMQGRYspddYRVRRSGKGGQSPQRSIEDSFRFEEkWH- 168  little brown bat
XP_003203102 105 SERT-EGNRRCQLPPKYSE--Ipykeh-------nrsfyHYKMEERYtfehYKVTGNEKGIKPFHRPLGASCKFERkWH- 173  turkey
XP_007668532 107 PERG-DGARRYQSAPKYPEG-Mppkeh-------erhfyGPKPQGRYpheeARGPGSGKGGQTFHRSPTESFPFQGpWP- 176  platypus
XP_023354706 131 PERG-DSSRNFHYIPKYLDT-Lpykeh-------ewhysSQKVSGRYvlddARFTGIGKEVKPLHRS-ADSFKFEGkWH- 199  Tasmanian devil
XP_010594053 100 PERG-DVNRRSQYMPKFSDG-Vpyneh-------erncyPQKVQGRYfpddYRVRGSRKGGKPSQRSVADSFRFEEkWH- 169  African savann...

XP_014352806 340 QKE----------------ESRAGESTSplVSSYLKRYL-EEQKNKATTQDRENGRE-KDqkakNEEREKVKERSGVSEM 401  coelacanth
XP_003466466 167 EDEfrhqrmqe-ekytqspRRGSEDFDT--RSSFQRRYP-EDRDFRKYGHTSKRTKD-VE----RDEKRESARNPKWKPK 237  Domestic guine...
XP_005998812 186 EDDlgqrrlpk-ekhsqspKRSSEEFLG--RSSYQERYP-EGPDFRKFGHSAERARE-ME----KHDGRESARDSKWKLH 256  coelacanth
XP_011234923 172 EDElrhqrvqd-enhsqslRRGSEDFEK--RSSFQKryP-EDRDFRKYGHTSKRPKD-VE----RYENRESARNPQWKFG 242  giant panda
XP_005227643 171 EAEpryqriqd-ekysqslRRGSEDFEK--RISFQKRYP-EDHDFRKYGHTSKRPHD-VE----RYENREPARSPQWKSR 241  cattle
XP_023609450 169 EDDlsyqmmqd-ekysqsfRRGSEDFEE--RSSFQTRYP-EDRDYRKYRHTSKRSAG-KK----KHENRDSSRNSHRKSR 239  little brown bat
XP_003203102 174 EDDlrhqrlhe-ekygqspRRVSDEFTS--RSSLQKRYP-EDHDYREYGHTSKRAKE-ME----RYDGGEVARNSKWKQE 244  turkey
XP_007668532 177 QEGsrpprtqdddqyvqapRRGSEESLT--RSSFPKRYPkEDREVRELGPTSKRTKEgPE----RYETRGPPRSAPWRAD 250  platypus
XP_023354706 200 EDElryqrtqe-dkyaqspRRGPEELVT--RSSFQKRYP-EDGDFREYGHSSKRTKD-ME----RYENREPSRNPKWKPE 270  Tasmanian devil
XP_010594053 170 EDEfkhqwiqe-ekypqlpRRGSEDSEA--RSSFQKRYP-EDRDFRKYQHTSKRPKD-VQ----RYENREPARHLRWEPE 240  African savann...

XP_014352806 402 GV--PFFKSDYLAPKNESESLYRGIPSPR---------RYRYSNELEKsmSAEFQE--EALHSMDMQ--ESEkkhrvkgl 466  coelacanth
XP_003466466 238 HSfpHYQEKKNQRNFGPQAHRYVKREYPDassa--tkvSYDYHHRHHK--LSNDNQdfTDGRTQKYL--KED-------- 303  Domestic guine...
XP_005998812 257 HPlpSCYKEEEHRE---HARQSVERRYFEgssa--akiAFEYDHKHPRriSPEGRLhfTDGKAESCSskVEA-------- 323  coelacanth
XP_011234923 243 HSlpSYQEKKEQRNLGPQTHQHALWEPPEtssa--tkvSCDYHHKRRK--TSGGDQefPDGRIQKYSkeEDR-------- 310  giant panda
XP_005227643 242 HFsaPYQEKKDQRNLETQTYRYAPREFPEtssa--akvSCDSRHKYRK--TSDGDKdfYDERAQKYPkeEDR-------- 309  cattle
XP_023609450 240 HYlpHYQEKEDQWNLRHRSHRHARRNSPEtssa--tkvSRDYHHKHPQ--TSDEDQdfSDGRTQKYYkeEDR-------- 307  little brown bat
XP_003203102 245 RSfpPYQEKEEQRNLGAQSHRSTEREYSEgsv---tkiAYEYNHKRRR--HLDGEKsfADDRAQKYAkqEDQ-------- 311  turkey
XP_007668532 251 HAlpPYPEPAGTRSHGPAARRSAEREHAAdgtgpgppgSYDYRHRHPK--PSAAEPgfSNGRGPKHAkeEER-------- 320  platypus
XP_023354706 271 HSfpSYQEKKGQRSVEPQNYRSAEREYLEdnsl--akiSYGYRHKHYK--HSDEEQsfSNGRTQKYSkeEDR-------- 338  Tasmanian devil
XP_010594053 241 SSlpPYQEKKDQRNFGPQTHRHTEREHTEtssv--akiSFDYCHKYHK--PTGGDQdfSGEGTQRYSkeEDR-------- 308  African savann...

XP_014352806 467 kdskledePKCKSKVIvpSTAKNQDTYE-ERLSKWEELAYFPSAKEkSWEDE--------DMEDEVYPGR--AKREE--- 532  coelacanth
XP_003466466 304 --------RKYSQKGP--VNRESGCFNA-GRERETEGRLDKDAIKP-PKKDCipc---ahLNKNEVKLKPcnDKWKKkmk 368  Domestic guine...
XP_005998812 324 --------PVSHLAAS--HNKATSCFTS-GMMRPAREGQWETSPKYnASVKYias---pnICKNDVDLRLlhMEQKGrvg 389  coelacanth
XP_011234923 311 --------KSSSQKGP--ENRHSVCFNA-GRGRDTEGGQVKEPSKP-SKKDCtdctssthSSKSDVGLRPcsDKQKEkgk 378  giant panda
XP_005227643 310 --------KLGSQKGP--VNRESSCSHA-GRGRETEGGQVKESSKP-SKKDCaal---thSDKSDVDLRSckDTRKDkik 374  cattle
XP_023609450 308 --------KYISQIDL--AERKSRYFNT-RRDRETEDGQVKEASKP-SKKDCsps---tdSDKNNVISSPynGKRKKkkn 372  little brown bat
XP_003203102 312 --------KYGSSKGAw-NSKKLDYFSG-GRARQTEEGHVEVPAKYsSKKGCnac---vnSSKMDADVRPfkNKQKErvr 378  turkey
XP_007668532 321 --------KYGSPKGPpvGGREADGLSG-GRARRTEGGPPDGSVKYgSPKGSagg---pgQYRNDVGLRAfhDPPRDrgr 388  platypus
XP_023354706 339 --------KYSSPKDS--LNRELDCFSSnGRMRDTEEGNVD-SLKY-PKKACgac---tnLYKNDIDMRLfsNKLKErvk 403  Tasmanian devil
XP_010594053 309 --------KYNSQKGS--VNRESDCFNG-GRGRETKDGLVKEPFKQ-AKKDCiag---tySNKSDVDSRPsnDEWKEkik 373  African savann...

XP_014352806 533 -----VKRAElGGyrgpipdknprsgsykvvherspsppprrSAEGKE-REKMATKEENPpiskttfSVYRGS-EINVRM 605  coelacanth
XP_003466466 369 kegncRKQNN-SS-----------------------------SNQSDIsQNLSSVKSSSI-------SLGKKSlTVKVDV 411  Domestic guine...
XP_005998812 390 kekdfRSNVD-SF-----------------------------QNHHEQnHRRMSLKTSNV-------SPKPETlTIKVDL 432  coelacanth
XP_011234923 379 kegdgRKESD-SS-----------------------------SNQLDKs-KLSNVKSSSA-------SLRKKSlTIKIDV 420  giant panda
XP_005227643 375 keragSKESS-SS-----------------------------SNQLDNsD--SDLKPSSV-------FLKKKSlTVKVDV 415  cattle
XP_023609450 373 kegdgRREGN-SS-----------------------------SYQFGKs----EYSPASL-------RKKSKSlIVKIDV 411  little brown bat
XP_003203102 379 kegelRRKGD-SS-----------------------------SSQHDSsHTVSDVKISDV-------NCRREHlTIKVDM 421  turkey
XP_007668532 389 kggefRKEQG-SP-----------------------------DGQRDPsRRAFCPKTSTL-------RHGPQSlTVKVDM 431  platypus
XP_023354706 404 keidlKKDQD-SF-----------------------------SSQHDTsHRLPDRKSSNV-------SLKRKLlTVKVDM 446  Tasmanian devil
XP_010594053 374 keenfRKESN-PS-----------------------------SSQLDKs-KLSDVKSSSF-------SGRRKLlTIKVDV 415  African savann...

XP_014352806 606 dALEDDFGSS---VAHERRLSRDLVHGNKKDLGFRSIFQHIQS--SQSRRSPSELFAQHIVTIVHHVKEHHFESPEMTLS 680  coelacanth
XP_003466466 412 -KKNVDPPRVassYSTERQMSHDLVAVGRKIEIFHPVFEHLDSp-QNTENKSSGEFAQEIITIIHQVKANYFPSPGVTLH 489  Domestic guine...
XP_005998812 433 kkam-dnyRPtssHGAERQLSQYLVAVSRKQDDFHPVFEHMGSnaHPVEHTPKVEFTQEIITLVHQVKDTYFKSPDLTLH 511  coelacanth
XP_011234923 421 kkti-ntsRVassYSTERQMSHDLVAVGRKSENFHPVFEHLDSt-QNTENKPTGEFAQEIITIIHQVKANYFPSPDITLH 498  giant panda
XP_005227643 416 qqgq-nksRVassYSTERQMSHDLVAVGRKSEKFHPVFEHLDSt-QNTENKPTGEFAQQIITIIHQVKANYFPPSEITLH 493  cattle
XP_023609450 412 kd---------------------tVNIPRKSKNFHPVFEHLVSt-QNTENKSTGEFSQEIITVIHQIKANTFSSSGVTLH 469  little brown bat
XP_003203102 422 kkmv-nryRAassHTTDRQMSHDLVAVGRKNESFHPVFEHMESvtRGVESDPSREFTQEIITIIHQIKANYFTSSDITLH 500  turkey
XP_007668532 432 kqpg-aqyR--------------------KTENFHPVCEHFDSapLNVENMPTSEFTQEIITIIHQIKANYFPSSDLTLH 490  platypus
XP_023354706 447 kktl---------------------dkyRKKENFHPVFEHLDSttQNVENKPSGEFTQEIITIIHQVKANYFPSSDLTLH 505  Tasmanian devil
XP_010594053 416 kkpv-dtfRVassYPTERQMSHDLVAVGRKSENFHPVFEHLDSt-QDIENKPTGEFTQEIITIIHQDKENYLSSPGITLH 493  African savann...

XP_014352806 681 ERFTMYQRRAM--EQGAARSKKSPEFHRRIDISPSAFRKHPFLQDEMKGSREsssykgegKYKeDPVDLRLDIERRKKY- 757  coelacanth
XP_003466466 490 ERFSKIQDTRDt-DVKECKLNSDPEIHRRIDMSLAELQSKQTTIYESDQTLV--------KVI-DPNDLRHDIERRRKEr 559  Domestic guine...
XP_005998812 512 ERFSNLQEVQPt-NSKGARANSGPEIHRRIDMSLADLQSKRLQNWGSVQTTM--------KLIeDPNDLRHDIERRRKRr 582  coelacanth
XP_011234923 499 ERFSKMQDTQAa-DVNEIKLNSDPEIHRRIDMSLAELQNKQTMVYEPEQTLV--------KII-DPNDLRHDIERRRKEr 568  giant panda
XP_005227643 494 ERFSKIQVKKAa-DANETKLSSDPEIHRRIDMSLAELQSKQTMVYDSKQTLV--------KII-DPSDLRHDIERRRKEr 563  cattle
XP_023609450 470 ERFSKIQDTPAtkGANELKSKLDPEIHRKIDMCLAELRNKQNTVCGSEQTQV--------KVI-DPNDLRHDIERRRKEr 540  little brown bat
XP_003203102 501 ERFSKIQDKPIp-NMNEVKRSLDPEIHRRIDMSLAELQNKRTVPSESPQNIV--------RVLeDPNDLRHDIERRRKEr 571  turkey
XP_007668532 491 ERFSKMQDTQAl-NRNVMKMNPDPEIHRRIDMSLAELQNKRTTICESGQAAV--------RVLeDPNDLRHDIERRRKEr 561  platypus
XP_023354706 506 ERFSKMQDTQVp-DINEIKMNSDPEIHRRIDMSLAELKNERTVKCEPGQAMF--------RVIeDPNDLRHDIERRRKEr 576  Tasmanian devil
XP_010594053 494 ERFSQLEVTRDa-GVNEIKLNSDPEIHRRIDMSLAELQSKQTIGYESEQSLV--------KII-DANDLRHDIERRRKQr 563  African savann...

XP_014352806 758 -KERDHKRDGS-----RESVDSRDSSQSRERs------------TEKAQREHKESKKR-K------------KQk--KIR 804  coelacanth
XP_003466466 560 lQNEDEHIFHIasateRNDHHPSFSKVKNIY-------------TDGFQKPTHFIKPNfRrfiqk--pylnyTM---QRK 621  Domestic guine...
XP_005998812 583 lQDQEIREFNe-----EDIPQSRFSNERTEQgsvsavemqeprfVKGFQKPNRFIQKPgRfirkpf-mnkfhSGtfiQRA 656  coelacanth
XP_011234923 569 lQNEDEHIFHIasaaeRNDEHSSFSRLKNTQ-------------VEEFQ------KSNfRkfiqk--phmnyPI---QRK 624  giant panda
XP_005227643 564 lQNEDEHIFHIasaaeRSDQHSSFSRSKDTH-------------VDEFQKPTSFEKSNfRkfiqk--pcssdTM---QRK 625  cattle
XP_023609450 541 lQNEDEHSFHIdsaaeRNNQFSCFS----SH-------------DDSFSNPHCVTRSNsRkfiqt--pytdyTM---QRN 598  little brown bat
XP_003203102 572 lKNEDERAFHTdgtapRNQQSCSFSRLQNSQ-------------LEGFQKPMRFIKPPfRkfigkphlnsyySS---RTN 635  turkey
XP_007668532 562 lQNEDERLFYLgdameR--------NGQNTH-------------TDGFKKPIRLMKPPfRkfirkp-ymntyFGt--KAN 617  platypus
XP_023354706 577 lQNEDERIFHIgrairRNDQNFNFSKLQNVH-------------TGGFQKPIRFFKPYfRkfvrksyknayhTS---KTK 640  Tasmanian devil
XP_010594053 564 lQNEDGHIFHIasateRNGQPSRFSKLKNTH-------------THRFRQSVYFTKSNcGkfvqkpnrgykniatei--- 627  African savann...

XP_014352806 805 SR--------SKSSSTSSHSSQSYK 821  coelacanth
XP_003466466 622 DTipq---klFGVERNHRGFKRPFK 643  Domestic guinea pig
XP_005998812 657 AFiqq---rpAGEVENPGSCKRPFQ 678  coelacanth
XP_011234923 625 GTitqkpfgvEGRRQNTTGfrrpik 649  giant panda
XP_005227643 626 DVithr-pfvEENNQNTRGFRRPFK 649  cattle
XP_023609450 599 NNsthkafkvERNHQNRRGF-RSFK 622  little brown bat
XP_003203102 636 DTfph--rhiRGRLENTGPIRRPFK 658  turkey
XP_007668532 618 DIfap--ksfGEDGENPGAIRRPFK 640  platypus
XP_023354706 641 DIindrpfgiRDNLPNPGTFRRPFK 665  Tasmanian devil
XP_010594053     -------------------------      African savanna elephant
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap